JNc-440 - ≥98% , CAS No.1119503-63-7

CAS: 1119503-63-7 Cat. No.: J651304 Peso molecular: 440.49

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

JNc-440 is a potent antihypertensive agent. JNc-440 can enhance the interaction of TRPV4 and Ca 2+ -activated potassium channel 3 ( KCa2.3 ) in endothelial cells. JNc-440 can also enhance vasodilation, and exerted antihypertensive effects in mice.

In Vivo

JNc-440 (1 mg/kg; IV; single dosage) improves endothelium-dependent relaxation in small resistance arteries and to lower blood pressure . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: TRPV4 -/- and wild‐type C57BL/6J mice (hypertensive induced by NOS inhibitor Nω-nitro-L-arginine, AngII and high-salt diet) Dosage: 1 mg/kg Administration: IV; single dosage Result: Increased the impaired TRPV4‐KCa2.3 interaction to improve endothelium‐dependent relaxation in small resistance arteries and to lower blood pressure.

Form:Solid

Specifications

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

JNc-440 is a potent antihypertensive agent. JNc-440 can enhance the interaction of TRPV4 and Ca 2+ -activated potassium channel 3 ( KCa2.3 ) in endothelial cells. JNc-440 can also enhance vasodilation, and exerted antihypertensive effects in mice.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: O=C(C(N1)=NC2=C(C=CC=C2)C1=O)NCCCNC(C(C3=CC=CC=C3)C4=CC=CC=C4)=O
• Peso molecular: 440.49