K 01-162 - ≥98% , CAS No.677746-25-7

CAS: 677746-25-7 Cat. No.: K648639 Peso molecular: 288.18 PubChem CID: 24858056

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

K 01-162 (K162) inhibits the fibril formation of A β peptides and eliminates their neurotoxicity. K 01-162 binds with A β 42 peptide with an EC 50 value of 80 nM. K 01-162 binds directly to AβO with a K D value of 19 μM. K 01-162 is capable of penetrating the brain and can be used for the research of Alzheimer’s disease.

In Vitro

K 01-162 (1 μM; 24 h) reduces the level of intracellular AβO. K 01-162 (0.78-50 μM; 5 min) blocks the synaptic binding activity of AβO in mouse hippocampal neurons. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MC65 cell line Concentration: 1 μM Incubation Time: 24 hours Result: Reduced the levels of SDS-stable Aβ trimer and larger aggregates.

In Vivo

K 01-162 (100 μM; intracerebroventricular infusion 0.25 μL/h for 2 weeks) attenuates amyloid load in vivo. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 5xFAD mice with cerebral Aβ amyloidosisDosage: 100 μM Administration: Intracerebroventricular infusion; 100 μM 0.25 μL/h; for 2 weeks Result: Caused no apparent toxicity and significantly reduced the amyloid load in hippocampus to\n50% of the mock-treated level.

Form:Solid

Specifications

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

K 01-162 (K162) inhibits the fibril formation of A β peptides and eliminates their neurotoxicity. K 01-162 binds with A β 42 peptide with an EC 50 value of 80 nM. K 01-162 binds directly to AβO with a K D value of 19 μM. K 01-162 is capable of penetrating

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

• Isómeros SMILES: CN(C)C1=CC2=C(C=C1)C3=C(C2)C=C(C=C3)Br
• PubChem CID: 24858056
• Peso molecular: 288.18

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO : 14.29 mg/mL (49.59 mM; Need ultrasonic)
• Peso molecular: 288.180 g/mol
• XLogP3: 4.500
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 287.031 Da
• Monoisotopic Mass: 287.031 Da
• Topological Polar Surface Area: 3.200 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 278.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1