KCC2 blocker 1 - 10mM in DMSO , CAS No.1228439-36-8

CAS: 1228439-36-8 Cat. No.: K656859 Fórmula: C₂₂H₂₅NO₅S Peso molecular: 415.50 PubChem CID: 46866400

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

KCC2 blocker 1 is an orally active and selective K + -Cl - cotransporter KCC2 blocker with an IC 50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate

In Vitro

KCC2 blocker 1 (compound 13; 100 μM) inhibits NKCC1 with 35%. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KCC2 blocker 1 (compound 13; 1 mg/kg iv and 6 mg/kg po) has a t 1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C max of 457 ng/mL and a AUC of 726 ng•h/mL for male Wistar rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats Dosage: 1 mg/kg or 6 mg/kg (Pharmacokinetic Analysis) Administration: IV (1 mg/kg) and PO (6 mg/kg) Result: Had a t 1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C max of 457 ng/mL and a AUC of 726 ng•h/mL.

IC50& Target:IC50: 1 μM (KCC2)

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

KCC2 blocker 1 is an orally active and selective K + -Cl - cotransporter KCC2 blocker with an IC 50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Nombres e identificadores

• Isómeros SMILES: CC(=O)N1CCCC1(CC2=CC=C(C=C2)S(=O)(=O)C)C(=O)OCC3=CC=CC=C3
• PubChem CID: 46866400
• Peso molecular: 415.50

Preguntas frecuentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1228439-36-8, the molecular formula is C22H25NO5S, and the molecular weight is 415.50 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.