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Koumine - 10mM in DMSO , CAS No.1358-76-5
Disponible para pedir
GRADE & PURITY 10mM in DMSO
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Why this grade
10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
Koumine can induce apoptosis of LoVo cells in a time-dependent manner and inhibit the DNA synthesis in LoVo cells, thereby blocking the cell cycle from G1 to S phase. Koumine has a significant analgesic effect in rodent behavioral models of inflammatory and neuropathic pain, and that the reduction in neuropathic pain may be associated with the upregulation of allopregnanolone in the spinal cord. Koumine has therapeutic effect against psoriasis, which is related to the inhibition of epidermal cell proliferation, promoting the formation of granular cells and decreasing the serum level of IL- Koumine can significantly reduce the damage to axon and myelin sheath of the sciatic nerve and increase sensory nerve conduction velocity , without affecting body weight and blood glucose, these findings encourage the use of koumine in the treatment of diabetic neuropathy. Koumine has antineoplastic effect, may be a future breast cancer chemotherapeutic agent. Koumine may produce anxiolytic-effect by increasing the levels of pregnenolone and allopregnenolone in hippocampus.
Specifications
Especificaciones y pureza
10mM in DMSO
Condiciones de almacenamiento de almacenamiento
Store at -80°C
Enviado en
Dry ice packs + Cold packs
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Tipo de acción
ACTIVATOR
Propiedades del producto
| ALogP | 1.879 |
|---|---|
| hba_count | 2 |
| Enlace rotable | 1 |
Nombres e identificadores
| Sonrisas canónicas | CN1CC2(C3CC4C5=NC6=CC=CC=C6C52CC1C3CO4)C=C |
|---|---|
| IUPAC Name | (1R,10R,12S,15S,16R,17S)-15-ethenyl-13-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.02,10.04,9.010,15.012,17]icosa-2,4,6,8-tetraene |
| InChIKey | VTLYEMHGPMGUOT-FXWNUWCSSA-N |
| INCHI | 1S/C20H22N2O/c1-3-19-11-22(2)16-9-20(19)13-6-4-5-7-15(13)21-18(20)17-8-14(19)12(16)10-23-17/h3-7,12,14,16-17H,1,8-11H2,2H3/t12-,14+,16-,17+,19-,20+/m0/s1 |
| Isómeros SMILES | CN1C[C@]2([C@@H]3C[C@@H]4C5=NC6=CC=CC=C6[C@]52C[C@H]1[C@H]3CO4)C=C |
| Peso molecular | 306.4 |
| Reaxy-Rn | 25328208 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25328208&ln= |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Estructura 3D
Modelo de Estructura Química Interactiva
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
| DMSO (mg/ml) Solubilidad máxima | 15 |
|---|---|
| DMSO (mM) Solubilidad máxima | 48.9553771084918 |
Calculadoras de soluciones
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