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KS100 , CAS No.2408477-54-1
Disponible para pedir
Storage
Store at 2-8°C,Desiccated
Shipped In
Wet ice
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Why this grade
for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at 2-8°C,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
KS100 is a potent ALDH inhibitor with IC 50 s of 230, 1542, 193 nM for ALDH1A1, ALDH2 , and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase
In Vitro
KS100 (compound 3j) (0-100 µM; 72 h) shows anti-proliferative activity with IC 50 s of 3.7, 2.1, 2.9, 2.5, 0.3, 1.0, 1.2, 1.3, 2.1, 9.8 µM for UACC 903, 1205 Lu, HCT116, HT29, NCIH929, U266, RPMI8226, MM.1R, MM.1S, FF2441 cells, respectively. KS100 (5 µM, 24 h) induces apoptosis and cell cycle arrest at the G2/M phase. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: HCT116, HT29 cells Concentration: 5 µM Incubation Time: 24 h Result: Induced cell apoptosis. Apoptosis AnalysisCell Line: HCT116 cells Concentration: 5 µM Incubation Time: 24 h Result: Induced cell cycle arrest at G2/M phase.
Form:Solid
IC50& Target:IC 50 : 230 nM (ALDH1A1),1542 nM (ALDH2),193 nM (ALDH3A1)
Specifications
Mecanismos bioquímicos y fisiológicos
KS100 is a potent ALDH inhibitor with IC 50 s of 230, 1542, 193 nM for ALDH1A1, ALDH2 , and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and
Condiciones de almacenamiento de almacenamiento
Store at 2-8°C, Desiccated
Enviado en
Wet ice
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Tipo de acción
INHIBITOR
Nombres e identificadores
| Peso molecular | 564.09 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
| Solubilidad | DMSO : 125 mg/mL (221.60 mM; Need ultrasonic) |
|---|
Calculadoras de soluciones
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