L-651,582 - ≥98%(HPLC) , CAS No.99519-84-3

CAS: 99519-84-3 Cat. No.: L288429 Peso molecular: 424.67 Número EC: 804-580-3

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L-651,582 - ≥98%(HPLC) CAS No(99519-84-3) by Aladdin Scientific

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Disponible para pedir

GRADE & PURITY ≥98%(HPLC)

Synonyms

CAI | L-651582 | 5-amino-1-{[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl}-1H-1,2,3-triazole-4-carboxamide | 5-AMINO-1-[[3,5-DICHLORO-4-(4-CHLOROBENZOYL)PHENYL]METHYL]-1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE | 5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]m

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general Specifications Nombres e identificadores Documentation Advanced Data Taxonomic Classification Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Calculadoras de soluciones Reseñas

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Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Product description

Carboxyamidotriazole (L-651582) is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole shows anti-tumor, anti-inflammatory and antiangiogenic effects.

Specifications

Sinónimos

CAI | L-651582 | 5-amino-1-{[3, 5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl}-1H-1, 2, 3-triazole-4-carboxamide | 5-AMINO-1-[[3, 5-DICHLORO-4-(4-CHLOROBENZOYL)PHENYL]METHYL]-1H-1, 2, 3-TRIAZOLE-4-CARBOXAMIDE | 5-amino-1-[[3, 5-dichloro-4-(4-chlorobenzoyl)phenyl]m

Especificaciones y pureza

≥98%(HPLC)

Mecanismos bioquímicos y fisiológicos

Orally active Ca2+channel blocker; inhibits K+- and carbachol-stimulated Ca2+influx (IC50values are 500 and 935 nM respectively). Exhibits antiproliferative, antiangiogenic and antimetastatic activityin vivoand displays selectivity towards numerous misma

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%(HPLC)

Nombres e identificadores

Pubchem Sid	504756650
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504756650
Sonrisas canónicas	C1=CC(=CC=C1C(=O)C2=C(C=C(C=C2Cl)CN3C(=C(N=N3)C(=O)N)N)Cl)Cl
IUPAC Name	5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]triazole-4-carboxamide
InChIKey	WNRZHQBJSXRYJK-UHFFFAOYSA-N
INCHI	1S/C17H12Cl3N5O2/c18-10-3-1-9(2-4-10)15(26)13-11(19)5-8(6-12(13)20)7-25-16(21)14(17(22)27)23-24-25/h1-6H,7,21H2,(H2,22,27)
Isómeros SMILES	C1=CC(=CC=C1C(=O)C2=C(C=C(C=C2Cl)CN3C(=C(N=N3)C(=O)N)N)Cl)Cl
CAS alternativo	187739-60-2
Peso molecular	424.67
Reaxy-Rn	4337032
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4337032&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Clase Benzene and substituted derivatives
    - Subclass Benzophenones

Kingdom	Organic compounds
Superclass	Benzenoids
Clase	Benzene and substituted derivatives
Subclass	Benzophenones
Intermediate Tree Nodes	Not available
Direct Parent	Benzophenones
Alternative Parents	Aryl-phenylketones Diphenylmethanes 2-heteroaryl carboxamides Dichlorobenzenes Benzoyl derivatives Aryl chlorides Vinylogous halides Vinylogous amides Triazoles Heteroaromatic compounds Primary carboxylic acid amides Amino acids and derivatives Azacyclic compounds Hydrocarbon derivatives Organic oxides Organochlorides Organopnictogen compounds Primary amines
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Benzophenone - Aryl-phenylketone - Diphenylmethane - 2-heteroaryl carboxamide - Benzoyl - Aryl ketone - 1,3-dichlorobenzene - Halobenzene - Chlorobenzene - Aryl chloride - Aryl halide - Azole - Heteroaromatic compound - Vinylogous amide - Vinylogous halide - 1,2,3-triazole - Primary carboxylic acid amide - Carboxamide group - Amino acid or derivatives - Ketone - Azacycle - Organoheterocyclic compound - Carboxylic acid derivative - Organooxygen compound - Primary amine - Organic nitrogen compound - Amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Aromatic heteromonocyclic compound
Descripción	This compound belongs to the class of organic compounds known as benzophenones. These are organic compounds containing a ketone attached to two phenyl groups.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estructura 3D

Objetivos asociados (humanos)

PTH1R Tclin Parathyroid hormone receptor (47172 Activities)

Discover Target: PTH1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GALR3 Tchem Galanin receptor 3 (273 Activities)

Discover Target: GALR3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A498 (42825 Activities)

Lot Number	Certificate Type	Fecha	Articulo
H2323129	Certificate of Analysis	Jun 09, 2026	L288429
H2323130	Certificate of Analysis	Jun 09, 2026	L288429
H2323131	Certificate of Analysis	Jun 09, 2026	L288429
H2323132	Certificate of Analysis	Jun 09, 2026	L288429
H2323134	Certificate of Analysis	Jun 09, 2026	L288429
H2323135	Certificate of Analysis	Jun 09, 2026	L288429
H2323136	Certificate of Analysis	Jun 09, 2026	L288429
H2323185	Certificate of Analysis	Jun 09, 2026	L288429
H2323194	Certificate of Analysis	Jun 09, 2026	L288429
H2323133	Certificate of Analysis	Aug 04, 2023	L288429
K2322447	Certificate of Analysis	Aug 04, 2023	L288429
K2322448	Certificate of Analysis	Aug 04, 2023	L288429
K2322449	Certificate of Analysis	Aug 04, 2023	L288429
K2322450	Certificate of Analysis	Aug 04, 2023	L288429

Solubilidad	Solvent:DMSO, Max Conc. mg/mL: 42.47, Max Conc. mM: 100
Peso molecular	424.700 g/mol
XLogP3	3.900
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	423.006 Da
Monoisotopic Mass	423.006 Da
Topological Polar Surface Area	117.000 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	549.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

L-651,582 - ≥98%(HPLC) , CAS No.99519-84-3

Why this grade

Storage & shipping

Quality documents

Literature proof

Descripción general

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

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