Determine the necessary mass, volume, or concentration for preparing a solution.
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L-Cycloserine - Moligand™, ≥97% , CAS No.339-72-0
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Why this grade
Moligand™, ≥97% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase, which is the first enzyme of the sphingolipid pathway, and causes the synthesis of sphingolipids to decrease. In vitro studies demonstrated that L-cyloserine inhibits 3-ketodihydrosphingosine synthetase 100 times more than D-Cycloserine .Research regarding L-Cycloserine and its effect on the immune response suggest that L-Cycloserine increases the level of IL-4 producing helper T cells and suppress the adhesion molecules CD29 and CD98. L-Cycloserine also inhibits SPTLC (serine palmitoyltransferase (SPT)), and HIV-1 investigations in the CD4+ lymphoid cell line (CEM) have shown that L-Cycloserine can inhibit HIV-1 replication.
An irreversible inhibitor of 3-ketodihydrosphingosine synthetase
Specifications
Sinónimos
(S)-4-Aminoisoxazolidin-3-one | (S)-Cycloserine
Especificaciones y pureza
Moligand™, ≥97%
Mecanismos bioquímicos y fisiológicos
Blocks sphingosine biosynthesis by inhibition of ketosphinganine synthetase. Cytotoxicity toward neuroblastoma and medulloblastoma cells mediated by suppression of ganglioside synthesis.
Condiciones de almacenamiento de almacenamiento
Store at 2-8°C
Enviado en
Wet ice
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Pureza
≥97%
Nombres e identificadores
| Pubchem Sid | 488189861 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488189861 |
| Sonrisas canónicas | C1C(C(=O)NO1)N |
| IUPAC Name | (4S)-4-amino-1,2-oxazolidin-3-one |
| InChIKey | DYDCUQKUCUHJBH-REOHCLBHSA-N |
| INCHI | 1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m0/s1 |
| Isómeros SMILES | C1[C@@H](C(=O)NO1)N |
| CAS alternativo | 339-72-0 |
| Peso molecular | 102.09 |
| Beilstein | 80799 |
| Reaxy-Rn | 80800 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=80800&ln= |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Taxonomic Classification
Taxonomy Tree
- Kingdom Organic compounds
- Superclass Organic acids and derivatives
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Clase | Carboxylic acids and derivatives |
| Subclass | Amino acids, peptides, and analogues |
| Intermediate Tree Nodes | Amino acids and derivatives |
| Direct Parent | Alpha amino acids and derivatives |
| Alternative Parents | Oxazolidinones Isoxazolidines Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aliphatic heteromonocyclic compounds |
| Substituents | Alpha-amino acid or derivatives - Oxazolidinone - Isoxazolidine - Organoheterocyclic compound - Azacycle - Oxacycle - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Primary amine - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Organic oxygen compound - Carbonyl group - Amine - Aliphatic heteromonocyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof. |
| External Descriptors | 4-amino-1,2-oxazolidin-3-one |
Estructura 3D
Modelo de Estructura Química Interactiva
Objetivos asociados (humanos)
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
ACHE Tclin Acetylcholinesterase (18204 Activities)
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HEK293 (82097 Activities)
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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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BLM Tchem Bloom syndrome protein (4248 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SLC36A1 Tchem Proton-coupled amino acid transporter 1 (102 Activities)
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Objetivos asociados (no humanos)
Staphylococcus aureus (210822 Activities)
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Mycobacterium tuberculosis (203094 Activities)
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Enterococcus faecalis (29875 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Splenocyte (1641 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
BCHE Cholinesterase (8742 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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nfo Endonuclease 4 (425 Activities)
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Cell membrane (1233 Activities)
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Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 G2426304 | Certificate of Analysis | May 19, 2026 | S136251 |
| D2318860 | Certificate of Analysis | Feb 11, 2025 | S136251 |
| D2318869 | Certificate of Analysis | Feb 11, 2025 | S136251 |
| D2318918 | Certificate of Analysis | Feb 11, 2025 | S136251 |
| G2426302 | Certificate of Analysis | Jul 04, 2024 | S136251 |
| G2426303 | Certificate of Analysis | Jul 04, 2024 | S136251 |
| H2514031 | Certificate of Analysis | Jul 04, 2024 | S136251 |
| K2429091 | Certificate of Analysis | Jul 04, 2024 | S136251 |
| D2318859 | Certificate of Analysis | Mar 16, 2023 | S136251 |
| D2318867 | Certificate of Analysis | Mar 16, 2023 | S136251 |
| D2318878 | Certificate of Analysis | Mar 16, 2023 | S136251 |
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Propiedades químicas y físicas
| Solubilidad | insoluble in EtOH; ≥42.9 mg/mL in H2O; ≥8.78 mg/mL in DMSO |
|---|---|
| Índice de refracción | 1.48 |
| Punto de fusión (°C) | 146°C |
| Peso molecular | 102.090 g/mol |
| XLogP3 | -1.500 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 0 |
| Exact Mass | 102.043 Da |
| Monoisotopic Mass | 102.043 Da |
| Topological Polar Surface Area | 64.400 Ų |
| Heavy Atom Count | 7 |
| Formal Charge | 0 |
| Complexity | 92.900 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
Calculadoras de soluciones
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