L-Glutamic acid monosodium salt hydrate - Moligand™, ≥99% , CAS No.6106-04-3

CAS: 6106-04-3 Cat. No.: S108801 Peso molecular: 187.13 Beilstein Registry Number: 4164348 Número EC: 612-072-6

GRADE & PURITY Moligand™, ≥99%

Synonyms

Sodium glutamate monohydrate | Sodium glutamate | SodiuM L-GlutaMate Monohydrate | monosodium l-glutamate monohydrate | Monosodium glutamate monohydrate | L-Glutamic acid monosodium salt monohydrate

Storage

Room temperature

Shipped In

Normal

Descripción general

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous system (CNS). It interacts with membrane bound glutamate receptors.

L-Glutamic acid monosodium salt hydrate has been used-
• as a chemical modulator to rat hippocampal slice cultures for the study of microglial movement post spreading depression (SD) prior to migraine
• as an additive to Neurobasal medium for the growth of embryonic neurons obtained from pregnant mice
• as a component of GYE (glucose yeast extract) solid medium for the growth of four strains of phytopathogen Xylella fastidiosa namely, CVC clone 9a5c, Temecula (Pierce’s disease), Jab1 (Coffee Leaf Scorch), and the isolate 6747 (Plum Leaf Scald), which causes diseases in important crop plants
• as a component of the stock solution for the equilibration of intracellular and extracellular [H+] in segmental nerves obtained from the ventral ganglion of Drosophila larvae
• as a supplement to RPMI (Roswell Park Memorial Institute) medium 1640 used to maintain K562 cell cultures with twice-weekly passage.

Specifications

Sinónimos

Sodium glutamate monohydrate | Sodium glutamate | SodiuM L-GlutaMate Monohydrate | monosodium l-glutamate monohydrate | Monosodium glutamate monohydrate | L-Glutamic acid monosodium salt monohydrate

Especificaciones y pureza

Moligand™, ≥99%

Mecanismos bioquímicos y fisiológicos

L-glutamate plays key roles in development, learning, memory, plasticity and cognition. It plays crucial role in the pathogenesis of neuropathological diseases such as epilepsy, schizophrenia, stroke, ischemia, ALS (amyotrophic lateral sclerosis), Hunting

Condiciones de almacenamiento de almacenamiento

Room temperature

Enviado en

Normal

Grado

Moligand™

Pureza

≥99%

Nombres e identificadores

• Pubchem Sid: 488200546
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488200546
• Sonrisas canónicas: C(CC(=O)[O-])C(C(=O)O)N.O.[Na+]
• IUPAC Name: sodium;(4S)-4-amino-5-hydroxy-5-oxopentanoate;hydrate
• InChIKey: GJBHGUUFMNITCI-QTNFYWBSSA-M
• INCHI: 1S/C5H9NO4.Na.H2O/c6-3(5(9)10)1-2-4(7)8;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;1H2/q;+1;/p-1/t3-;;/m0../s1
• Isómeros SMILES: C(CC(=O)[O-])[C@@H](C(=O)O)N.O.[Na+]
• WGK Alemania: 2
• RTECS: MA1575000
• CAS alternativo: 142-47-2;32221-81-1
• Peso molecular: 187.13
• Beilstein: 4164348
• Reaxy-Rn: 4164348

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Glutamic acid and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Glutamic acid and derivatives
• Alternative Parents: L-alpha-amino acids Amino fatty acids Dicarboxylic acids and derivatives Carboxylic acid salts Amino acids Carboxylic acids Organic zwitterions Organic sodium salts Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Glutamic acid or derivatives - Alpha-amino acid - L-alpha-amino acid - Amino fatty acid - Dicarboxylic acid or derivatives - Fatty acid - Fatty acyl - Carboxylic acid salt - Amino acid - Carboxylic acid - Organic alkali metal salt - Organic salt - Organic zwitterion - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Hydrocarbon derivative - Organic oxide - Carbonyl group - Organic oxygen compound - Amine - Organic nitrogen compound - Organic sodium salt - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as glutamic acid and derivatives. These are compounds containing glutamic acid or a derivative thereof resulting from reaction of glutamic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: Soluble in water.
• Rotación específica [α]: 25 ° (C=10, 2mol/L HCl)
• Punto de fusión (°C): 232 °C (dec.) (lit.)
• Peso molecular: 187.130 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 187.046 Da
• Monoisotopic Mass: 187.046 Da
• Topological Polar Surface Area: 104.000 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 149.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

Referencias

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