L-NIL hydrochloride - ≥98% , CAS No.150403-89-7

CAS: 150403-89-7 Cat. No.: L286740 Peso molecular: 223.7 Número EC: 633-953-1 PubChem CID: 9794509

GRADE & PURITY ≥98%

Synonyms

HY-12117 | SR-01000597893 | SCHEMBL1321685 | (S)-6-acetimidamido-2-aminohexanoic acid hydrochloride | L-NIL hydrochloride | L-NILHCl | AKOS024456411 | N6-(1-Iminoethyl)-L-lysine hydrochloride | -Acetimidoyllysine hydrochloride | L-NIL (hydrochloride) | (2

Storage

Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

Descripción general

Product Description
selective inhibitor of inducible nitric oxide synthase
Product Application

L-N6-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor: to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murine to study its effects on leptin-induced inflammation in hepatocytes to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)

Specifications

Sinónimos

HY-12117 | SR-01000597893 | SCHEMBL1321685 | (S)-6-acetimidamido-2-aminohexanoic acid hydrochloride | L-NIL hydrochloride | L-NILHCl | AKOS024456411 | N6-(1-Iminoethyl)-L-lysine hydrochloride | -Acetimidoyllysine hydrochloride | L-NIL (hydrochloride) | (2

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

A selective inhibitor of inducible nitric oxide synthase (IC50= 3.3μM).

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Argon charged, Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: CC(=NCCCCC(C(=O)O)N)N.Cl
• IUPAC Name: (2S)-2-amino-6-(1-aminoethylideneamino)hexanoic acid;hydrochloride
• InChIKey: HJYWSATZDBEAOS-FJXQXJEOSA-N
• INCHI: 1S/C8H17N3O2.ClH/c1-6(9)11-5-3-2-4-7(10)8(12)13;/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13);1H/t7-;/m0./s1
• Isómeros SMILES: CC(=NCCCC[C@@H](C(=O)O)N)N.Cl
• PubChem CID: 9794509
• Peso molecular: 223.7

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Alpha amino acids
              • Level8 L-alpha-amino acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids
• Direct Parent: L-alpha-amino acids
• Alternative Parents: Medium-chain fatty acids Amino acids Propargyl-type 1,3-dipolar organic compounds Monocarboxylic acids and derivatives Carboxylic acids Carboximidamides Carboxamidines Organic oxides Monoalkylamines Hydrochlorides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: L-alpha-amino acid - Medium-chain fatty acid - Fatty acid - Fatty acyl - Amino acid - Amidine - Carboxylic acid amidine - Carboxylic acid - Monocarboxylic acid or derivatives - Carboximidamide - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Organic nitrogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Carbonyl group - Amine - Primary aliphatic amine - Organic oxygen compound - Organic oxide - Hydrochloride - Hydrocarbon derivative - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Solvent:water, Max Conc. mg/mL: 22.37, Max Conc. mM: 100
• Sensibilidad: Moisture sensitive.
• Peso molecular: 223.700 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 223.109 Da
• Monoisotopic Mass: 223.109 Da
• Topological Polar Surface Area: 102.000 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 192.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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