L-Thyroxine(T4) - Moligand™, 10mM in DMSO , Agonist of Thyroid hormone receptor-α;Agonist of Thyroid hormone receptor-β, CAS No.51-48-9, Agonist of Thyroid hormone receptor-α;Agonist of Thyroid hormone receptor-β

CAS: 51-48-9 Cat. No.: L408317 Peso molecular: 776.87 Beilstein Registry Number: 2228515 Número EC: 200-101-1 PubChem CID: 5819
Disponible para pedir
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
Synonyms
NSC 36397 | O-​(4-​hydroxy-​3,​5-​diiodophenyl)​-​3,​5-​diiodo-L-​tyrosine
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
1ml
L408317-1ml
1
105,90US$
Enter a quantity for the sizes you want to add.
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Why this grade

Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 11 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Information

L-Thyroxine (NSC 36397) is a synthetic form of thyroxine and a hormone replacement drug.
In vitro


In vivo


Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥97%

Specifications

Sinónimos
NSC 36397 | O-​(4-​hydroxy-​3, ​5-​diiodophenyl)​-​3, ​5-​diiodo-L-​tyrosine
Especificaciones y pureza
Moligand™, 10mM in DMSO
Mecanismos bioquímicos y fisiológicos
L-Thyroxine (NSC 36397) is a synthetic form of thyroxine and a hormone replacement drug.
Condiciones de almacenamiento de almacenamiento
Store at -80°C
Enviado en
Dry ice packs + Cold packs
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Tipo de acción
AGONIST
Mecanismo de acción
Agonist of Thyroid hormone receptor-α;Agonist of Thyroid hormone receptor-β
Nombres e identificadores
Isómeros SMILES C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@@H](C(=O)O)N
PubChem CID 5819
Peso molecular 776.87
Beilstein 2228515

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Objetivos asociados (humanos)
THRA Tclin Thyroid hormone receptor alpha (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
THRB Tclin Thyroid hormone receptor beta (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
Punto de fusión (°C)223°C
Citations of This Product
Referencias
1. Xinyi Li, Kaiyue Li, Jiayi Li, Zhiqin Zhang, Hongyuan Wang.  (2023)  Effects of perchlorate and exogenous T4 on growth, development and tail resorption of Rana chensinensis.  ENVIRONMENTAL POLLUTION,      [PMID:37558196] [10.1016/j.envpol.2023.122333]
2. Yangyang Wang, Yanping Sun, Bingyou Yang, Qiuhong Wang, Haixue Kuang.  (2022)  Integrate metabolomics strategy and target prediction to reveal the ameliorate effect of four typical ‘cold’ property herbs on hyperthyroidism rats.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:36202164] [10.1016/j.jep.2022.115772]
3. Wang Yang-Yang, Sun Yan-Ping, Yang Bing-You, Wang Qiu-Hong, Kuang Hai-Xue.  (2022)  Application of metabolomics and network analysis to reveal the ameliorating effect of four typical “hot” property herbs on hypothyroidism rats.  Frontiers in Pharmacology,      [PMID:36091783] [10.3389/fphar.2022.955905]
4. Quan Chi, Wenxiang Zhang, Lang Wang, Juan Huang, Ming Yuan, Huaming Xiao, Xian Wang.  (2019)  Evaluation of structurally different brominated flame retardants interacting with the transthyretin and their toxicity on HepG2 cells.  CHEMOSPHERE,      [PMID:31927367] [10.1016/j.chemosphere.2019.125749]
5. Mei Yang, Youning Ma, Wenjun Gui, Yiping Ren, Guonian Zhu, Yihua Liu.  (2015)  Determination of 26 endocrine disrupting chemicals in fish and water using modified QuEChERS combined with solid-phase extraction and UHPLC-MS/MS.  Analytical Methods,  (19): (8418-8431).  [PMID:] [10.1039/C5AY01082A]
6. Fei Wei, Xueyi Wu, Hongyuan Wang, Yongpu Zhang, Lei Xie.  (2025)  Methimazole disrupted skeletal ossification and muscle fiber transition in Bufo gargarizans larvae.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:39793290] [10.1016/j.ecoenv.2025.117684]
7. Ting Tai, Yuan-Yuan Shao, Yu-Qi Zheng, Li-Ping Jiang, Hao-Ru Han, Na Yin, Hao-Dong Li, Jin-Zi Ji, Qiong-Yu Mi, Li Yang, Lei Feng, Fu-Yang Duan, Hong-Guang Xie.  (2024)  Clopidogrel ameliorates high-fat diet-induced hepatic steatosis in mice through activation of the AMPK signaling pathway and beyond.  Frontiers in Pharmacology,      [PMID:39508046] [10.3389/fphar.2024.1496639]
8. Lei Xie, Ziyi Niu, Shimin Xiao, Hongyuan Wang, Yongpu Zhang.  (2024)  Morphological and Transcriptomic Analyses Reveal the Toxicological Mechanism and Risk of Nitrate Exposure in Bufo gargarizans Embryos.  Animals,  14  (6): (961).  [PMID:38540059] [10.3390/ani14060961]
9. Zhilin Yang, Nan Yuan, Yaning Gong, Yang Jiao, Najun Li, Jianmei Lu.  (2025)  High-Concentrated Reactive Oxygen Species from Chiral Thyroxine for Piezocatalytic Antitumor Therapy.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202519435]
10. Shengxian Liang, Shaojun Liang, Nuoya Yin, Francesco Faiola.  (2019)  Establishment of a human embryonic stem cell-based liver differentiation model for hepatotoxicity evaluations.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:30849655] [10.1016/j.ecoenv.2019.02.091]
11. Pingfa Gao, Lyuping Hu, Songzhou Lu, Dongxu Feng, Yingying Wang, Zhewei Fei, Wei Wu.  (2025)  Levothyroxine suppression therapy improves maternal and neonatal outcomes in pregnancy after thyroidectomy for differentiated thyroid carcinoma.  American Journal of Translational Research,  17  (11): (8643).  [PMID:41415087] [10.62347/UTCU8727]
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