Lanicemine dihydrochloride - 10mM in DMSO , CAS No.153322-06-6

CAS: 153322-06-6 Cat. No.: L654903 Peso molecular: 271.19 Número EC: 642-428-6 PubChem CID: 9795446

GRADE & PURITY 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker ( K i of 0.56-2.1 μM for NMDA receptor ; IC 50 s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects

In Vivo

Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects .\nLanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats Dosage: 3, 10 or 30 mg/kg Administration: Intraperitoneal Result: Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity.

IC50& Target:NMDA receptor

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker ( K i of 0.56-2.1u2009μM for NMDA receptor ; IC 50 s of 4-7u2009μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects.

Condiciones de almacenamiento de almacenamiento

Desiccated, Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

ANTAGONIST

Nombres e identificadores

• Isómeros SMILES: C1=CC=C(C=C1)[C@H](CC2=CC=CC=N2)N.Cl.Cl
• WGK Alemania: 3
• PubChem CID: 9795446
• Peso molecular: 271.19