LDN 212320 - ≥98%(HPLC) , CAS No.894002-50-7

CAS: 894002-50-7 Cat. No.: L287431 Peso molecular: 293.39

GRADE & PURITY ≥98%(HPLC)

Synonyms

3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine | LDN-212320 | LDN/OSU-0212320, LDN-0212320, OSU-0212320 | 3-((2-methylbenzyl)thio)-6-(pyridin-2-yl)pyridazine

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Sinónimos

3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine | LDN-212320 | LDN/OSU-0212320, LDN-0212320, OSU-0212320 | 3-((2-methylbenzyl)thio)-6-(pyridin-2-yl)pyridazine

Especificaciones y pureza

≥98%(HPLC)

Mecanismos bioquímicos y fisiológicos

Increases expression of glutamate transporter EAAT2 in PA-EAAT2 cells. Displays neuroprotective activityin vivo.Shown to improve learning and memory, restore synaptic integrity and reduce amyloid plaque burden in APPSw/Ind mice.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

ACTIVATOR

Pureza

≥98%(HPLC)

Nombres e identificadores

• Pubchem Sid: 504764734
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504764734
• Sonrisas canónicas: CC1=CC=CC=C1CSC2=NN=C(C=C2)C3=CC=CC=N3
• IUPAC Name: 3-[(2-methylphenyl)methylsulfanyl]-6-pyridin-2-ylpyridazine
• InChIKey: DUUQLWDHNYFUPP-UHFFFAOYSA-N
• INCHI: 1S/C17H15N3S/c1-13-6-2-3-7-14(13)12-21-17-10-9-16(19-20-17)15-8-4-5-11-18-15/h2-11H,12H2,1H3
• Isómeros SMILES: CC1=CC=CC=C1CSC2=NN=C(C=C2)C3=CC=CC=N3
• Peso molecular: 293.39
• Reaxy-Rn: 21840389
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=21840389&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Diazines
      • Subclass Pyrimidines and pyrimidine derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Diazines
• Subclass: Pyrimidines and pyrimidine derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyridinylpyrimidines
• Alternative Parents: Toluenes Alkylarylthioethers Pyridines and derivatives Pyridazines and derivatives Heteroaromatic compounds Sulfenyl compounds Azacyclic compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pyridinylpyrimidine - Aryl thioether - Toluene - Alkylarylthioether - Monocyclic benzene moiety - Pyridazine - Pyridine - Benzenoid - Heteroaromatic compound - Thioether - Sulfenyl compound - Azacycle - Hydrocarbon derivative - Organic nitrogen compound - Organonitrogen compound - Organosulfur compound - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as pyridinylpyrimidines. These are compounds containing a pyridinylpyrimidine skeleton, which consists of a pyridine linked (not fused) to a pyrimidine by a bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (no humanos)

Slc1a2 Excitatory amino acid transporter 2 (39 Activities)

Discover Target: Slc1a2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Solvent:DMSO, Max Conc. mg/mL: 29.34, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 5.87, Max Conc. mM: 20
• Peso molecular: 293.400 g/mol
• XLogP3: 3.200
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 293.099 Da
• Monoisotopic Mass: 293.099 Da
• Topological Polar Surface Area: 64.000 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 312.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1