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Ledipasvir D-tartrate - ≥98% , CAS No.1502654-87-6
Disponible para pedir
GRADE & PURITY ≥98%
Storage
Store at 2-8°C,Desiccated
Shipped In
Wet ice
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at 2-8°C,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
Ledipasvir D-tartrate is an inhibitor of the hepatitis C virus NS5A , with EC 50 values of 34 pM against GT1a and 4 pM against GT1b replicon.
In Vitro
Ledipasvir has GT1a and 1b EC 50 values of 31 and 4 pM, respectively, and protein-adjusted EC 50 values of 210 pM (GT1a) and 27 pM (GT1b) and the intrinsic EC 50 of 39 is 310 fM for GT1a and 40 fM for GT1b. Ledipasvir is highly protein-bound both in human serum and in the cell-culture medium (containing 10% BSA) of the replicon assay. Ledipasvir exhibits an EC 50 value of 141 nM against the JFH/3a-NS5A replicon. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Ledipasvir is remarkable not only on the basis of its high replicon potency but also on the basis of its low clearance, good bioavailability, and long half-lives in rat, dog, and monkey and low predicted clearance in human. The pharmacokinetics of Ledipasvir is measured in rats and dogs. Ledipasvir shows good half-lives (rat 1.83 ± 0.22 hr, dog 2.63 ± 0.18 hr) in plasma, low systemic clearance (CL), and moderate volumes of distribution (Vss) that are greater than total body water volume . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:EC50: 34 pM (GT1a), 4 pM (GT1b)
Specifications
Especificaciones y pureza
≥98%
Mecanismos bioquímicos y fisiológicos
Ledipasvir D-tartrate is an inhibitor of the hepatitis C virus NS5A , with EC 50 values of 34 pM against GT1a and 4 pM against GT1b replicon.
Condiciones de almacenamiento de almacenamiento
Store at 2-8°C, Desiccated
Enviado en
Wet ice
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Tipo de acción
INHIBITOR
Pureza
≥98%
Nombres e identificadores
| Peso molecular | 1039.09 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
| Solubilidad | DMSO : 25 mg/mL (24.06 mM; Need ultrasonic) |
|---|
Calculadoras de soluciones
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