Leukotriene E4 - Moligand™, ≥97%, 100ug/ml in ethanol , Agonist of CysLT 1 receptor;Agonist of CysLT 2 receptor;Agonist of GPR17;Agonist of oxoglutarate receptor, CAS No.75715-89-8, Agonist of CysLT 1 receptor;Agonist of CysLT 2 receptor;Agonist of GPR17;Agonist of oxoglutarate receptor

CAS: 75715-89-8 Cat. No.: L274987 Peso molecular: 439.61

GRADE & PURITY Moligand™, ≥97%, 100ug/ml in ethanol

Synonyms

(5S,6R,7E,9E,11Z,14Z)-6-(2-AMINO-2-CARBOXYETHYL)SULFANYL-5-HYDROXYICOSA-7,9,11,14-TETRAENOIC ACID | 7,9,11,14-Eicosatetraenoicacid, 6-[[(2R)-2-amino-2-carboxyethyl]thio]-5-hydroxy-, (5S,6R,7E,9E,11Z,14Z)- | LEUKOTRIEN E4 | BDBM50297387 | S-{(1R,2E,4E,6Z,9

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Product Describtion:

Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4. Leukotriene E4 is one of the components of the slow reacting substance (SRS-A) of allergic reactions. Leukotriene E4 accumulates in plasma and urine, and urinary excretion of Leukotriene E4 is most commonly used as an indicator of asthma

Specifications

Sinónimos

(5S, 6R, 7E, 9E, 11Z, 14Z)-6-(2-AMINO-2-CARBOXYETHYL)SULFANYL-5-HYDROXYICOSA-7, 9, 11, 14-TETRAENOIC ACID | 7, 9, 11, 14-Eicosatetraenoicacid, 6-[[(2R)-2-amino-2-carboxyethyl]thio]-5-hydroxy-, (5S, 6R, 7E, 9E, 11Z, 14Z)- | LEUKOTRIEN E4 | BDBM50297387 | S-{(1R, 2E, 4E, 6Z, 9

Especificaciones y pureza

Moligand™, ≥97%, 100ug/ml in ethanol

Mecanismos bioquímicos y fisiológicos

Partial, selective CysLT 1 and CysLT 2 agonist (EC 50 values are 55.9 and 59 nM, respectively). Induces hypotension and bronchoconstriction. Active in vivo and in vitro .

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

AGONIST

Mecanismo de acción

Agonist of CysLT 1 receptor;Agonist of CysLT 2 receptor;Agonist of GPR17;Agonist of oxoglutarate receptor

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥97%

Nombres e identificadores

• Sonrisas canónicas: CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)O)N
• IUPAC Name: (5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-amino-2-carboxyethyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
• InChIKey: OTZRAYGBFWZKMX-FRFVZSDQSA-N
• INCHI: 1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1
• Isómeros SMILES: CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N
• CAS alternativo: 75715-89-8
• Términos de entrada MeSH: Leukotriene E;Leukotriene E 4;Leukotriene E-4;Leukotriene E4;Leukotrienes E;LTE4
• Peso molecular: 439.61
• Reaxy-Rn: 38369841
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=38369841&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Clase Fatty Acyls
      • Subclass Eicosanoids

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Clase: Fatty Acyls
• Subclass: Eicosanoids
• Intermediate Tree Nodes: Not available
• Direct Parent: Leukotrienes
• Alternative Parents: Hydroxyeicosatetraenoic acids Long-chain fatty acids L-cysteine-S-conjugates L-alpha-amino acids Hydroxy fatty acids Thia fatty acids Dicarboxylic acids and derivatives Unsaturated fatty acids Secondary alcohols Amino acids Sulfenyl compounds Dialkylthioethers Carboxylic acids Organopnictogen compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides Monoalkylamines
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Leukotriene - Hydroxyeicosatetraenoic acid - Long-chain fatty acid - L-cysteine-s-conjugate - Cysteine or derivatives - Alpha-amino acid - Alpha-amino acid or derivatives - L-alpha-amino acid - Hydroxy fatty acid - Thia fatty acid - Dicarboxylic acid or derivatives - Fatty acid - Unsaturated fatty acid - Amino acid or derivatives - Amino acid - Secondary alcohol - Carboxylic acid derivative - Carboxylic acid - Dialkylthioether - Sulfenyl compound - Thioether - Amine - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Alcohol - Carbonyl group - Organopnictogen compound - Primary aliphatic amine - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Primary amine - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as leukotrienes. These are eicosanoids containing a hydroxyl group attached to the aliphatic chain of an arachidonic acid. Leukotrienes have four double bonds, three (and only three) of which are conjugated.
• External Descriptors: Leukotrienes

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

GPR17 Tchem Uracil nucleotide/cysteinyl leukotriene receptor (0 Activities)

Discover Target: GPR17

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYSLTR2 Tchem Cysteinyl leukotriene receptor 2 (0 Activities)

Discover Target: CYSLTR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 (0 Activities)

Discover Target: CYSLTR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

P2RY12 Tclin P2Y purinoceptor 12 (1 Activities)

Discover Target: P2RY12

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OXGR1 Tchem 2-oxoglutarate receptor 1 (1 Activities)

Discover Target: OXGR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

P2RY12 Tclin Purinergic receptor P2Y12 (2369 Activities)

Discover Target: P2RY12

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 (2118 Activities)

Discover Target: CYSLTR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYSLTR2 Tchem Cysteinyl leukotriene receptor 2 (135 Activities)

Discover Target: CYSLTR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (1191 Activities)

Discover Target: ABCC2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Abcc1 Multidrug resistance-associated protein 1 (42 Activities)

Discover Target: Abcc1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMF: 50 mg/ml；DMSO: 50 mg/ml；Ethanol: 50 mg/ml；PBS pH 7.2: 0.1 mg/ml
• Peso molecular: 439.600 g/mol
• XLogP3: 2.100
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 18
• Exact Mass: 439.239 Da
• Monoisotopic Mass: 439.239 Da
• Topological Polar Surface Area: 146.000 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 586.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 3
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 4
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 4
• Covalently-Bonded Unit Count: 1

Referencias

1. FengShengyong , MaEnhao , NaXiaona , WangZongmei , TaiWanbo , BaoXinhui , WangMao , ChangHan , WuBaolei , LiuMiaoxi , LiJuzhen , ShiHuicheng , YangCeli , XiMenglu , YangHaibing , LiYuhan , ZhuYibin , WangPenghua , ZhaoLing , ZhaoAi , ChengGong.  (2025)  Dietary supplementation of arachidonic acid promotes humoral immunity.  EMBO Molecular Medicine,      [PMID:40940568] [10.1038/s44321-025-00310-7]