Levosimendan - Moligand™,10mM in DMSO , Troponin, cardiac muscle positive modulator, CAS No.141505-33-1, Troponin, cardiac muscle positive modulator

CAS: 141505-33-1 Cat. No.: L407801 Peso molecular: 280.28 Número EC: 663-528-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(R)-2-(2-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)hydrazono)malononitrile

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Levosimendan is acalcium sensitizeracting through calcium-dependent binding tocardiac troponin C (cTnC), provides treatment for heart failure.
In vitro

Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC). Levosimendan at 3 μM decreases the value of Ca50 from 2.73μM to 1.19 μM. levosimendan exhibits its calcium sensitizing effect through calcium-dependent binding to the N-terminal domain of cTnC. Levosimendan significantly hyperpolarizes resting potential of rat mesenteric arterial myocytes with an EC50 of 2.9 μM and maximal effect (19.5 mV) at 10 μM, probably through activation of a glibenclamide-sensitive K⁺ channel. Levosimendan has inotropic and lusitropic actions in failing human myocardium, with average maximum increase in twitch tension of 47% at a levosimendan concentration of 0.8 μM. Levosimendan causes rapid dose-dependent improvement in hemodynamic function in patients with decompensated heart failure.

In vivo

Levosimendan at low concentrations (0.03 to 0.1 μM) acts preferably as a Ca2+ sensitizer, whereas at higher concentrations (0.1 to 0.3 μmol/L) its action as a phosphodiesterase inhibitor contributes to the positive inotropic effect.
Cell Data

cell lines：A2780, A2780/cp70, 2780AD, HCT116, HT29, WIL, CALU-3, MCF7, PC3 and HS852

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

(R)-2-(2-(4-(4-methyl-6-oxo-1, 4, 5, 6-tetrahydropyridazin-3-yl)phenyl)hydrazono)malononitrile

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Troponin, cardiac muscle positive modulator

Propiedades del producto

• ALogP: 2.3

Nombres e identificadores

• Isómeros SMILES: C[C@@H]1CC(=O)NN=C1C2=CC=C(C=C2)NN=C(C#N)C#N
• WGK Alemania: 3
• RTECS: TY1570210
• Peso molecular: 280.28
• Reaxy-Rn: 6959884
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6959884&ln=

Propiedades químicas y físicas

• Rotación específica [α]: -627° (C=0.5,THF)
• Punto de fusión (°C): 210-214°C