Lidocaine , CAS No.137-58-6

CAS: 137-58-6 Cat. No.: L1371946-GMP Peso molecular: 234.34 Beilstein Registry Number: 12(4)2538 Número EC: 205-302-8

Storage

Room temperature

Shipped In

Normal

Descripción general

Lidocaine (GMP) is Lidocaine produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Lidocaine inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia.

Specifications

Condiciones de almacenamiento de almacenamiento

Room temperature

Enviado en

Normal

Propiedades del producto

• ALogP: 2.3

Nombres e identificadores

• Sonrisas canónicas: CCN(CC)CC(=O)NC1=C(C=CC=C1C)C
• IUPAC Name: 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
• InChIKey: NNJVILVZKWQKPM-UHFFFAOYSA-N
• INCHI: 1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
• Isómeros SMILES: CCN(CC)CC(=O)NC1=C(C=CC=C1C)C
• WGK Alemania: 3
• RTECS: AN7525000
• Peso molecular: 234.34
• Beilstein: 12(4)2538
• Reaxy-Rn: 2215784
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2215784&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Benzene and substituted derivatives
      • Subclass Xylenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Benzene and substituted derivatives
• Subclass: Xylenes
• Intermediate Tree Nodes: Not available
• Direct Parent: m-Xylenes
• Alternative Parents: Trialkylamines Propargyl-type 1,3-dipolar organic compounds Carboximidic acids Organopnictogen compounds Organooxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: M-xylene - Tertiary aliphatic amine - Tertiary amine - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidic acid derivative - Carboximidic acid - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Amine - Aromatic homomonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as m-xylenes. These are aromatic compounds that contain a m-xylene moiety, which is a monocyclic benzene carrying exactly two methyl groups at the 1- and 3-positions.
• External Descriptors: tertiary amino compound - monocarboxylic acid amide - benzenes

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Punto de ebullición (°C): 182 °C/4 mmHg
• Punto de fusión (°C): 69 °C

Referencias

1. Xuewen Cai, Lu Zheng, Erdeng Du, Rui Ma, Jun Chen, Yao Wu, Jiayao Li, Xichen Wang, Mingguo Peng.  (2025)  Multispectral Analysis and Molecular Simulation of the Interactions Between Perfluorodecanoic Acid/Perfluorosebacic Acid and Human Serum Albumin.  JOURNAL OF MOLECULAR RECOGNITION,  38  (4): (e70008).  [PMID:40602794] [10.1002/jmr.70008]

2. Jiezhou Pan, Haotian Liao, Guidong Gong, Yunxiang He, Qin Wang, Lang Qin, Yaoyao Zhang, Hirotaka Ejima, Blaise L. Tardy, Joseph J. Richardson, Jiaojiao Shang, Orlando J. Rojas, Yong Zeng, Junling Guo.  (2023)  Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels.  JOURNAL OF CONTROLLED RELEASE,      [PMID:37422124] [10.1016/j.jconrel.2023.07.003]

3. Meichao Liao, Lin Yang, Xiaoyue Yang, Erxu Wang, Bin Lu, Jiye Wang, Li Duan.  (2022)  Vortex-assisted liquid–liquid microextraction based on hydrophobic deep eutectic solvent for the urinary excretion study of Taraxacum mongolicum extract in rats.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2022.108167]

4. Xiangtian Ling, Xinqi Ma, Xielan Kuang, Yuxiu Zou, Han Zhang, Han Tang, Han Du, Binbin Zhu, Hao Huang, Qing Xia, Minghao Chen, Danyi Mao, Dongli Chen, Huangxuan Shen, Jianhua Yan.  (2022)  Lidocaine Inhibits Myoblast Cell Migration and Myogenic Differentiation Through Activation of the Notch Pathway.  Drug Design Development and Therapy,      [PMID:33688167] [10.2147/DDDT.S290002]

5. Ronghao Liu, Jinjie Hao, Yangyang Wang, Yuanyuan Meng, Yanzhao Yang.  (2022)  A separation strategy of Au(III), Pd(II) and Pt(IV) based on hydrophobic deep eutectic solvent from hydrochloric acid media.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2022.120200]

6. Meichao Liao, Yang Zhao, Xiaoyue Yang, Lin Yang, E-Hu Liu, Bin Lu, Jiye Wang, Xiaopeng Liu, Yanzhong Chang, Li Duan.  (2022)  A greener and sustainable route for medicinal plant analysis: Recycle utilization of hydrophobic deep eutectic solvent.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2022.107372]

7. Yuemei Cen, Haihang Wang, Ping Wen, Genying Xu, Feng Tian, Fenggang Bian, Xiangqiong Zeng.  (2022)  The development of an artificial skin membrane mimicking the lipid bilayer structure for in vitro permeation study.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2022.128609]

8. Boyou Zhang, Fei Sun, Yi Lu, Zhihao Wang, Zhiming Shen, Lei Yuan, Qiang Wu, Cong Wu, Hongcan Shi.  (2022)  A novel decellularized trachea preparation method for the rapid construction of a functional tissue engineered trachea to repair tracheal defects.  Journal of Materials Chemistry B,  10  (25): (4810-4822).  [PMID:35237780] [10.1039/D1TB02100A]

9. Renchuan Liang, Jinghang Jiang, Yanyan Zheng, Ajabkhan Sailjoi, Jie Chen, Jiyang Liu, Hongxue Li.  (2021)  Vertically oriented mesoporous silica film modified fluorine-doped tin oxide electrode for enhanced electrochemiluminescence detection of lidocaine in serum.  RSC Advances,  11  (55): (34669-34675).  [PMID:35494748] [10.1039/D1RA06375H]

10. Jing Li, Yanjun Jiao, Qin Luo, Weixin Hu, Shenwen Fang, Chunling Tang, Qiang Liu.  (2021)  Treatment of oil-based drill cuttings by hydrophobic deep eutectic solvents.  CANADIAN JOURNAL OF CHEMICAL ENGINEERING,  100  (8): (1747-1754).  [PMID:] [10.1002/cjce.24263]

11. Jing Lu, Wenjie Tian, Linxian Cui, Bing Cai, Tingting Zhang, Nan Huang, Lei Lu, Tao Zhu.  (2021)  Lidocaine-eluting endotracheal tube effectively attenuates intubation related airway response.  Annals of Translational Medicine,      [PMID:34164505] [10.21037/atm-21-1930]

12. Yongqiang Zhang, Yingying Cao, Xiangzhan Meng, Chunshan Li, Hui Wang, Suojiang Zhang.  (2020)  Enhancement of transdermal delivery of artemisinin using microemulsion vehicle based on ionic liquid and lidocaine ibuprofen.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:32109824] [10.1016/j.colsurfb.2020.110886]

13. Xue Ren, Man He, Beibei Chen, Bin Hu.  (2019)  Magnetic porous organic polymers for extraction of cardiovascular drugs in human urine samples followed by HPLC-UV.  Analytical Methods,  12  (2): (141-148).  [PMID:] [10.1039/C9AY02041A]

14. Wenying Fan, Man He, Linna You, Xuewei Zhu, Beibei Chen, Bin Hu.  (2016)  Water-compatible graphene oxide/molecularly imprinted polymer coated stir bar sorptive extraction of propranolol from urine samples followed by high performance liquid chromatography-ultraviolet detection.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:26993782] [10.1016/j.chroma.2016.03.017]

15. Li Jianlong, Zhang Jinmi, Hu Maoyuan, Jin Yao, Li Sheng, Xiong Xiaoli.  (2025)  Construction of an enhanced electrochemical sensor for quercetin in food samples via binary MOF on MOF hybrids.  MICROCHIMICA ACTA,  192  (12): (855).  [PMID:41291129] [10.1007/s00604-025-07697-7]

16. Yicong Jia, Hong Chen, Qianhui Zou, Sijing Chen, Jiahao Li, Yiming Chen, Liming Lu, Feng Hong, Shuhui Jia, Xiaoyuan Jing, Jiayan Ren, Fahim Muhammad, JiaYu Mi, Jing Duan, Jianxiang Liao, Qing Liu, Fuqiang Xu, Paul J. Kenny, Ming-Hu Han, Liping Wang, Zuxin Chen, Dezhi Cao, Xin-an Liu.  (2026)  Gut-brain cholinergic signaling mediates the antiseizure effects of Bacteroides fragilis.  NEURON,      [PMID:41547348] [10.1016/j.neuron.2025.11.029]

17. Shutao Ma, Li Weng, Xiang Yin, Mohamed EL-Newehy, Meera Moydeen Abdulhameed, Jiahui Song, Lu Han, Linpeng Fan, Mingyi Shang, Xiumei Mo.  (2026)  Preparation of nanofibrous membrane-covered saccule gastric tubes and their treatment of radiation esophagitis.  Acta Biomaterialia,      [PMID:41839339] [10.1016/j.actbio.2026.03.019]