Lidocaine - Moligand™, 10mM in DMSO , Sodium channel alpha subunit blocker, CAS No.137-58-6, Sodium channel alpha subunit blocker

CAS: 137-58-6 Cat. No.: L408441 Peso molecular: 234.34 Beilstein Registry Number: 12(4)2538 Número EC: 205-302-8
Disponible para pedir
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
Synonyms
Alphacaine | 2-​(diethylamino)​-​N-​(2,​6-​dimethylphenyl)​-acetamide
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
1ml
L408441-1ml
2
75,90US$
Enter a quantity for the sizes you want to add.
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Why this grade

Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 17 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Information

Lidocaine Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.
In vitro


In vivo


Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥99%

Specifications

Sinónimos
Alphacaine | 2-​(diethylamino)​-​N-​(2, ​6-​dimethylphenyl)​-acetamide
Especificaciones y pureza
Moligand™, 10mM in DMSO
Mecanismos bioquímicos y fisiológicos
Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.
Condiciones de almacenamiento de almacenamiento
Store at -80°C
Enviado en
Dry ice packs + Cold packs
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Tipo de acción
BLOCKER, CHANNEL BLOCKER
Mecanismo de acción
Sodium channel alpha subunit blocker
Propiedades del producto
ALogP2.3
Nombres e identificadores
Isómeros SMILES CCN(CC)CC(=O)NC1=C(C=CC=C1C)C
WGK Alemania 3
RTECS AN7525000
Peso molecular 234.34
Beilstein 12(4)2538
Reaxy-Rn 2215784
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2215784&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Objetivos asociados (humanos)
SCN2A Tclin Sodium channel protein type 2 subunit alpha (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SCN5A Tclin Sodium channel protein type 5 subunit alpha (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SCN10A Tclin Sodium channel protein type 10 subunit alpha (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SCN9A Tclin Sodium channel protein type 9 subunit alpha (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SCN4A Tclin Sodium channel protein type 4 subunit alpha (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
Punto de ebullición (°C)182 °C/4 mmHg
Punto de fusión (°C)69 °C
Citations of This Product
Referencias
1. Jiezhou Pan, Haotian Liao, Guidong Gong, Yunxiang He, Qin Wang, Lang Qin, Yaoyao Zhang, Hirotaka Ejima, Blaise L. Tardy, Joseph J. Richardson, Jiaojiao Shang, Orlando J. Rojas, Yong Zeng, Junling Guo.  (2023)  Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels.  JOURNAL OF CONTROLLED RELEASE,      [PMID:37422124] [10.1016/j.jconrel.2023.07.003]
2. Meichao Liao, Lin Yang, Xiaoyue Yang, Erxu Wang, Bin Lu, Jiye Wang, Li Duan.  (2022)  Vortex-assisted liquid–liquid microextraction based on hydrophobic deep eutectic solvent for the urinary excretion study of Taraxacum mongolicum extract in rats.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2022.108167]
3. Xiangtian Ling, Xinqi Ma, Xielan Kuang, Yuxiu Zou, Han Zhang, Han Tang, Han Du, Binbin Zhu, Hao Huang, Qing Xia, Minghao Chen, Danyi Mao, Dongli Chen, Huangxuan Shen, Jianhua Yan.  (2022)  Lidocaine Inhibits Myoblast Cell Migration and Myogenic Differentiation Through Activation of the Notch Pathway.  Drug Design Development and Therapy,      [PMID:33688167] [10.2147/DDDT.S290002]
4. Ronghao Liu, Jinjie Hao, Yangyang Wang, Yuanyuan Meng, Yanzhao Yang.  (2022)  A separation strategy of Au(III), Pd(II) and Pt(IV) based on hydrophobic deep eutectic solvent from hydrochloric acid media.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2022.120200]
5. Meichao Liao, Yang Zhao, Xiaoyue Yang, Lin Yang, E-Hu Liu, Bin Lu, Jiye Wang, Xiaopeng Liu, Yanzhong Chang, Li Duan.  (2022)  A greener and sustainable route for medicinal plant analysis: Recycle utilization of hydrophobic deep eutectic solvent.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2022.107372]
6. Yuemei Cen, Haihang Wang, Ping Wen, Genying Xu, Feng Tian, Fenggang Bian, Xiangqiong Zeng.  (2022)  The development of an artificial skin membrane mimicking the lipid bilayer structure for in vitro permeation study.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2022.128609]
7. Boyou Zhang, Fei Sun, Yi Lu, Zhihao Wang, Zhiming Shen, Lei Yuan, Qiang Wu, Cong Wu, Hongcan Shi.  (2022)  A novel decellularized trachea preparation method for the rapid construction of a functional tissue engineered trachea to repair tracheal defects.  Journal of Materials Chemistry B,  10  (25): (4810-4822).  [PMID:35237780] [10.1039/D1TB02100A]
8. Renchuan Liang, Jinghang Jiang, Yanyan Zheng, Ajabkhan Sailjoi, Jie Chen, Jiyang Liu, Hongxue Li.  (2021)  Vertically oriented mesoporous silica film modified fluorine-doped tin oxide electrode for enhanced electrochemiluminescence detection of lidocaine in serum.  RSC Advances,  11  (55): (34669-34675).  [PMID:35494748] [10.1039/D1RA06375H]
9. Jing Li, Yanjun Jiao, Qin Luo, Weixin Hu, Shenwen Fang, Chunling Tang, Qiang Liu.  (2021)  Treatment of oil-based drill cuttings by hydrophobic deep eutectic solvents.  CANADIAN JOURNAL OF CHEMICAL ENGINEERING,  100  (8): (1747-1754).  [PMID:] [10.1002/cjce.24263]
10. Jing Lu, Wenjie Tian, Linxian Cui, Bing Cai, Tingting Zhang, Nan Huang, Lei Lu, Tao Zhu.  (2021)  Lidocaine-eluting endotracheal tube effectively attenuates intubation related airway response.  Annals of Translational Medicine,      [PMID:34164505] [10.21037/atm-21-1930]
11. Yongqiang Zhang, Yingying Cao, Xiangzhan Meng, Chunshan Li, Hui Wang, Suojiang Zhang.  (2020)  Enhancement of transdermal delivery of artemisinin using microemulsion vehicle based on ionic liquid and lidocaine ibuprofen.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:32109824] [10.1016/j.colsurfb.2020.110886]
12. Xue Ren, Man He, Beibei Chen, Bin Hu.  (2019)  Magnetic porous organic polymers for extraction of cardiovascular drugs in human urine samples followed by HPLC-UV.  Analytical Methods,  12  (2): (141-148).  [PMID:] [10.1039/C9AY02041A]
13. Wenying Fan, Man He, Linna You, Xuewei Zhu, Beibei Chen, Bin Hu.  (2016)  Water-compatible graphene oxide/molecularly imprinted polymer coated stir bar sorptive extraction of propranolol from urine samples followed by high performance liquid chromatography-ultraviolet detection.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:26993782] [10.1016/j.chroma.2016.03.017]
14. Xuewen Cai, Lu Zheng, Erdeng Du, Rui Ma, Jun Chen, Yao Wu, Jiayao Li, Xichen Wang, Mingguo Peng.  (2025)  Multispectral Analysis and Molecular Simulation of the Interactions Between Perfluorodecanoic Acid/Perfluorosebacic Acid and Human Serum Albumin.  JOURNAL OF MOLECULAR RECOGNITION,  38  (4): (e70008).  [PMID:40602794] [10.1002/jmr.70008]
15. Li Jianlong, Zhang Jinmi, Hu Maoyuan, Jin Yao, Li Sheng, Xiong Xiaoli.  (2025)  Construction of an enhanced electrochemical sensor for quercetin in food samples via binary MOF on MOF hybrids.  MICROCHIMICA ACTA,  192  (12): (855).  [PMID:41291129] [10.1007/s00604-025-07697-7]
16. Yicong Jia, Hong Chen, Qianhui Zou, Sijing Chen, Jiahao Li, Yiming Chen, Liming Lu, Feng Hong, Shuhui Jia, Xiaoyuan Jing, Jiayan Ren, Fahim Muhammad, JiaYu Mi, Jing Duan, Jianxiang Liao, Qing Liu, Fuqiang Xu, Paul J. Kenny, Ming-Hu Han, Liping Wang, Zuxin Chen, Dezhi Cao, Xin-an Liu.  (2026)  Gut-brain cholinergic signaling mediates the antiseizure effects of Bacteroides fragilis.  NEURON,      [PMID:41547348] [10.1016/j.neuron.2025.11.029]
17. Shutao Ma, Li Weng, Xiang Yin, Mohamed EL-Newehy, Meera Moydeen Abdulhameed, Jiahui Song, Lu Han, Linpeng Fan, Mingyi Shang, Xiumei Mo.  (2026)  Preparation of nanofibrous membrane-covered saccule gastric tubes and their treatment of radiation esophagitis.  Acta Biomaterialia,      [PMID:41839339] [10.1016/j.actbio.2026.03.019]
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