Lipoprotein Lipase Activator - 10mM in DMSO , CAS No.133208-93-2

CAS: 133208-93-2 Cat. No.: L421258 Peso molecular: 451.25 Número EC: 634-329-1

GRADE & PURITY 10mM in DMSO

Synonyms

DMAA (Antiparkinson Agent) | Ibrolipim [USAN] | J-006332 | Lipoprotein Lipase Activator | N-(4-bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide | Q5984863 | 2-Methyl-1,4-naphthochinon | HY-117549 | NO-1886 | AKOS005067076 | Diethyl 4-((4-bromo-2

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Lipoprotein Lipase Activator is a cell-permeable benzylphosphonate derivative that selectively induces lipoprotein lipase (LPL) mRNA and protein levels, but does not exhibit PPARα or PPARγ agonistic activities. Lipoprotein Lipase Activator lowers serum lipid levels and plasma triglycerides with concomitant elevation in high-density lipoprotein cholesterol (HDL-C) in animal models. Lipoprotein Lipase Activator also induces fatty acid oxidation related enzymes, lowers free fatty acids (FFA), and minimizes fat accumulation. Also reported to suppress the plasma levels of TNF-a and COX-2 and displays anti-tumor properties.

Specifications

Sinónimos

DMAA (Antiparkinson Agent) | Ibrolipim [USAN] | J-006332 | Lipoprotein Lipase Activator | N-(4-bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide | Q5984863 | 2-Methyl-1, 4-naphthochinon | HY-117549 | NO-1886 | AKOS005067076 | Diethyl 4-((4-bromo-2

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Lipoprotein lipase activator. Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis. Long-term administration of NO-1886 protects against the development of experimental athero

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Propiedades del producto

• pKa: pKa: 11.51 (Predicted)

Nombres e identificadores

• Sonrisas canónicas: CCOP(=O)(CC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)Br)C#N)OCC
• IUPAC Name: N-(4-bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide
• InChIKey: KPRTURMJVWXURQ-UHFFFAOYSA-N
• INCHI: 1S/C19H20BrN2O4P/c1-3-25-27(24,26-4-2)13-14-5-7-15(8-6-14)19(23)22-18-10-9-17(20)11-16(18)12-21/h5-11H,3-4,13H2,1-2H3,(H,22,23)
• Isómeros SMILES: CCOP(=O)(CC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)Br)C#N)OCC
• WGK Alemania: 3
• Peso molecular: 451.25
• Reaxy-Rn: 7497256
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7497256&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Benzene and substituted derivatives
      • Subclass Anilides
        • Level5 Aromatic anilides
          • Level6 Benzanilides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Benzene and substituted derivatives
• Subclass: Anilides
• Intermediate Tree Nodes: Aromatic anilides
• Direct Parent: Benzanilides
• Alternative Parents: Benzamides Benzoyl derivatives Benzonitriles Dialkyl alkylphosphonates Bromobenzenes Phosphonic acid esters Aryl bromides Secondary carboxylic acid amides Nitriles Organopnictogen compounds Organophosphorus compounds Organooxygen compounds Organobromides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Benzanilide - Benzamide - Benzoic acid or derivatives - Benzonitrile - Benzoyl - Dialkyl alkylphosphonate - Bromobenzene - Halobenzene - Phosphonic acid diester - Phosphonic acid ester - Aryl bromide - Aryl halide - Organophosphonic acid derivative - Secondary carboxylic acid amide - Carboxamide group - Carboxylic acid derivative - Nitrile - Carbonitrile - Hydrocarbon derivative - Organohalogen compound - Organobromide - Organonitrogen compound - Organooxygen compound - Organopnictogen compound - Organic oxygen compound - Organophosphorus compound - Organic nitrogen compound - Organic oxide - Aromatic homomonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as benzanilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with a benzene ring. They have the general structure RNC(=O)R', where R,R'= benzene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

LPL Tchem Lipoprotein lipase (101 Activities)

Discover Target: LPL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPTEC (172 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Índice de refracción: n20D1.59 (Predicted)
• Punto de ebullición (°C): 512.47° C at 760 mmHg (Predicted)
• Punto de fusión (°C): 90.27° C (Predicted)
• Peso molecular: 451.200 g/mol
• XLogP3: 3.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 450.034 Da
• Monoisotopic Mass: 450.034 Da
• Topological Polar Surface Area: 88.400 Ų
• Heavy Atom Count: 27
• Formal Charge: 0
• Complexity: 576.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1