Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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224,000+ productos de investigación · Triple ISO certified · COA & SDS Disponible para cada producto · Same-day shipping on in-stock items
Why this grade
Moligand™, ≥97% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 12 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
Liquiritigenin is a flavonoid and an estrogenic compound found in licorice (Glycyrrhizae radix) root extract and several other plants.
Application：
Liquiritigenin has been used:to study its inhibitory effect on tumor metastasis in the treatment of colorectal cancer；as a reference standard for ultra-performance liquid chromatography (UPLC) of Chaihu-Shugan-San (CSS) extract；as a potential antiviral drug against hepatitis C virus (HCV) infection.
Specifications
Especificaciones y pureza
Moligand™, ≥97%
Mecanismos bioquímicos y fisiológicos
Liquiritigenin displays anti-diabetic and choleretic properties. It exerts anti-inflammatory activity on Raw246.7 cells by inhibiting nuclear factor kappa light chain enhancer of activated B cells (NF-κB)-dependent-induction of inducible NOS (iNOS). Liq
Condiciones de almacenamiento de almacenamiento
Store at 2-8°C, Argon charged
Enviado en
Wet ice
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Pureza
≥97%
Nombres e identificadores
| Sonrisas canónicas | Oc1ccc(cc1)[C@@H]2CC(=O)c3ccc(O)cc3O2 |
|---|---|
| IUPAC Name | (2S)-7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one |
| InChIKey | FURUXTVZLHCCNA-AWEZNQCLSA-N |
| INCHI | 1S/C15H12O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-7,14,16-17H,8H2/t14-/m0/s1 |
| Isómeros SMILES | C1[C@H](OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O |
| WGK Alemania | 3 |
| RTECS | DJ2981789 |
| PubChem CID | 114829 |
| Peso molecular | 256.25 |
| Beilstein | 359378 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Taxonomic Classification
Taxonomy Tree
- Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
- Clase Flavonoids
- Subclass Flavans
- Clase Flavonoids
- Superclass Phenylpropanoids and polyketides
| Kingdom | Organic compounds |
|---|---|
| Superclass | Phenylpropanoids and polyketides |
| Clase | Flavonoids |
| Subclass | Flavans |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Flavanones |
| Alternative Parents | 7-hydroxyflavonoids 4'-hydroxyflavonoids Chromones Aryl alkyl ketones Alkyl aryl ethers 1-hydroxy-2-unsubstituted benzenoids Benzene and substituted derivatives Oxacyclic compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | 4'-hydroxyflavonoid - 7-hydroxyflavonoid - Hydroxyflavonoid - Flavanone - Chromone - Chromane - 1-benzopyran - Benzopyran - Aryl alkyl ketone - Aryl ketone - 1-hydroxy-2-unsubstituted benzenoid - Alkyl aryl ether - Phenol - Monocyclic benzene moiety - Benzenoid - Ketone - Oxacycle - Organoheterocyclic compound - Ether - Organic oxygen compound - Organic oxide - Organooxygen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as flavanones. These are compounds containing a flavan-3-one moiety, with a structure characterized by a 2-phenyl-3,4-dihydro-2H-1-benzopyran bearing a ketone at the carbon C3. |
| External Descriptors | Flavanones |
Estructura 3D
Modelo de Estructura Química Interactiva
Objetivos asociados (humanos)
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
CYP19A1 Tclin Cytochrome P450 19A1 (6099 Activities)
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|---|
TYR Tclin Tyrosinase (717 Activities)
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|---|
ACHE Tclin Acetylcholinesterase (18204 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
XDH Tclin Xanthine dehydrogenase (1038 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ESR2 Tclin Estrogen receptor beta (9272 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
JUN Tchem Proto-oncogene c-JUN (434 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP1B1 Tchem Cytochrome P450 1B1 (1148 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MMP3 Tchem Matrix metalloproteinase 3 (3433 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CYP1A1 Tchem Cytochrome P450 1A1 (1169 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MMP7 Tchem Matrix metalloproteinase 7 (1073 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
YES1 Tclin Tyrosine-protein kinase YES (2781 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CCRF-CEM (65223 Activities)
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|---|
DU-145 (51482 Activities)
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|---|
HCT-8 (3484 Activities)
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|---|
HL-60 (67320 Activities)
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|---|
HT-1080 (3966 Activities)
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|---|
K562 (73714 Activities)
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|---|
MCF7 (126967 Activities)
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|---|
PANC-1 (6144 Activities)
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|---|
SGC-7901 (2773 Activities)
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|---|
SW480 (6023 Activities)
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|---|
U-937 (7138 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
A549 (127892 Activities)
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|---|
T47D (39041 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HCT-116 (91556 Activities)
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|---|
HepG2 (196354 Activities)
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|---|
Ishikawa (877 Activities)
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|---|
HeLa (62764 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MDA-MB-231 (73002 Activities)
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|---|
RELA Tchem Nuclear factor NF-kappa-B p65 subunit (627 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
PSMB5 Tclin Proteasome Macropain subunit MB1 (2451 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Objetivos asociados (no humanos)
NA Neuraminidase (1107 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mmp13 Matrix metalloproteinase 13 (19 Activities)
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|---|
Mmp2 Matrix metalloproteinase-2 (12 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Hdac6 Histone deacetylase 6 (222 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mmp9 Matrix metalloproteinase 9 (38 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mus musculus (284745 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Rattus norvegicus (775804 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Influenza A virus (11224 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
B16 (5829 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MDCK (10148 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
RAW264.7 (28094 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
rep Replicase polyprotein 1ab (378 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
BCHE Cholinesterase (8742 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Prevotella intermedia (369 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
prtC Collagenase (8 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SARS-CoV-2 (38078 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 F2622302 | Certificate of Analysis | Jun 29, 2026 | L752230 |
| F2622303 | Certificate of Analysis | Jun 29, 2026 | L752230 |
| F2622304 | Certificate of Analysis | Jun 29, 2026 | L752230 |
| C2604575 | Certificate of Analysis | Mar 11, 2026 | L752230 |
| C2604576 | Certificate of Analysis | Mar 11, 2026 | L752230 |
| C2604578 | Certificate of Analysis | Mar 11, 2026 | L752230 |
| H2522589 | Certificate of Analysis | Sep 02, 2025 | L752230 |
| H2522590 | Certificate of Analysis | Sep 02, 2025 | L752230 |
| H2522591 | Certificate of Analysis | Sep 02, 2025 | L752230 |
| L2423077 | Certificate of Analysis | Dec 24, 2024 | L752230 |
| L2423078 | Certificate of Analysis | Dec 24, 2024 | L752230 |
| L2423079 | Certificate of Analysis | Dec 24, 2024 | L752230 |
| L2423080 | Certificate of Analysis | Dec 24, 2024 | L752230 |
| L2423081 | Certificate of Analysis | Dec 24, 2024 | L752230 |
| L2423082 | Certificate of Analysis | Dec 24, 2024 | L752230 |
Show more ⌵
Propiedades químicas y físicas
| Solubilidad | DMSO: 100 mg/mL (390.24 mM), Sonication is recommended. |
|---|---|
| Peso molecular | 256.250 g/mol |
| XLogP3 | 2.200 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 1 |
| Exact Mass | 256.074 Da |
| Monoisotopic Mass | 256.074 Da |
| Topological Polar Surface Area | 66.800 Ų |
| Heavy Atom Count | 19 |
| Formal Charge | 0 |
| Complexity | 335.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
Citations of This Product
Referencias
| 1. Xiaoran Ning, Yanhui Ni, Jingjing Cao, Huaxing Zhang. (2023) Liquiritigenin Attenuated Collagen-Induced Arthritis and Cardiac Complication via Inflammation and Fibrosis Inhibition in Mice. CHEMICAL & PHARMACEUTICAL BULLETIN, 71 (4): (269-276). [PMID:37005251] [10.1248/cpb.c22-00684] |
| 2. Bin Guo, Xu-Ran Fan, Zhong-Ze Fang, Yun-Feng Cao, Cui-Min Hu, Julin Yang, Yan-Yan Zhang, Rong-Rong He, Xu Zhu, Zhen-Wen Yu, Xiao-Yu Sun, Mo Hong, Lu Yang. (2012) Deglycosylation of Liquiritin Strongly Enhances its Inhibitory Potential Towards UDP-Glucuronosyltransferase (UGT) Isoforms. PHYTOTHERAPY RESEARCH, 27 (8): (1232-1236). [PMID:23065713] [10.1002/ptr.4855] |
| 3. Yinhuang Gao, Peng Zhao, Chunyan Wang, Keren Fang, Yueqing Pan, Yan Zhang, Zhishuo Miao, Meirong Wang, Minlong Wei, Wei Zou, Menghua Liu, Kang Peng. (2024) Buqi Huoxue Tongnao prescription protects against chronic cerebral hypoperfusion via regulating PI3K/AKT and LXRα/CYP7A1 signaling pathways. PHYTOMEDICINE, [PMID:38959552] [10.1016/j.phymed.2024.155844] |
| 4. Ziyao Chen, Dongju Zhao, Meng Cheng, Fan Yang, Yining Liu, Jin Chang, Yan Dou. (2024) Female-sensitive multifunctional phytoestrogen nanotherapeutics for tailored management of postmenopausal Alzheimer's disease. Nano Today, [PMID:] [10.1016/j.nantod.2023.102119] |
| 5. Peng Deng, Qifan Wang, Shengfang Wu, Xiuwen Zhou, Fatih Oz, Qiuming Chen, Zhaojun Wang, Zhiyong He, Jie Chen, Maomao Zeng. (2025) Synergistic effect of spice extracts on multiple hazards formation and sensory markers in beef flavoring. Food Bioscience, [PMID:] [10.1016/j.fbio.2025.106099] |
| 6. Na Li, Liyan Liu, Huiqing Luo, Huaqiao Wang, Depo Yang, Feng He. (2020) Flavanone-Based Fluorophores with Aggregation-Induced Emission Enhancement Characteristics for Mitochondria-Imaging and Zebrafish-Imaging. MOLECULES, 25 (14): (3298). [PMID:32708080] [10.3390/molecules25143298] |
| 7. Hui Cao, Xiaojuan Liu, Nataša Poklar Ulrih, Pradeep K. Sengupta, Jianbo Xiao. (2018) Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach. FOOD CHEMISTRY, [PMID:30174044] [10.1016/j.foodchem.2018.07.111] |
| 8. Fangfei Zhou, Qingge Lu, Lingyu Kong, Sitong Wang, Haixia Zhang, Meng Zhao, Yue Hu, Fanwu Wu, Chenxi Wu. (2025) Glycyrrhiza uralensis Fisch. suppresses cell migration via ROS and JAK/STAT signalling pathways in Drosophila. Frontiers in Pharmacology, [PMID:40657637] [10.3389/fphar.2025.1549920] |
| 9. Ruoxue Bai, Manling Li, Yingyi Zhang, Jiangwei He, Yujin Lin, Haoran Zhang, Ping Shu, Xiaojing Yan, Bo wang, Tingting Huang, Xue Zhao, Xinfeng Zhao. (2025) Purification-free immobilization of dopamine D2 receptor and glucocorticoid receptor by alkyne–azide cycloaddition for affinity chromatography-based drug screening. JOURNAL OF CHROMATOGRAPHY A, [PMID:41352078] [10.1016/j.chroma.2025.466596] |
| 10. Ying Liu, Linlin Yu, Le Wang, Xiaowei Fang, Tenggao Zhu, Huanwen Chen, Wenliu Zhang, Dong Wu. (2026) Changes in Components During Quality Formation and Evaluation of Honey-Processed Glycyrrhiza uralensis Fisch. from Different Geographical Origins by Sequential Electrospray Ionization Mass Spectrometry. ACS Omega, [PMID:41585634] [10.1021/acsomega.5c08675] |
| 11. Xiang Meng, Muzhou Xue, Zequn Zeng, Wenbin Pei, Bing Gong. (2026) Liquiritigenin-loaded poly (acrylic acid)-carboxymethyl cellulose hydrogels: formulation optimization, performance evaluation, and assessment of therapeutic efficacy for wound healing and sepsis caused by wound bacterial infection. Frontiers in Bioengineering and Biotechnology, [PMID:41625074] [10.3389/fbioe.2025.1732535] |
| 12. Qin Zhou, Yushi Wei, Yijing Liao, Deming Gong, Guowen Zhang. (2026) Inhibition effect of vitamin B6 on α-glucosidase and mechanism of its synergistic inhibition with liquiritigenin. FOOD CHEMISTRY, [PMID:41592502] [10.1016/j.foodchem.2026.148130] |
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