Litronesib - 10mM in DMSO , Kinesin-like protein 1 inhibitor, CAS No.910634-41-2, Kinesin-like protein 1 inhibitor

CAS: 910634-41-2 Cat. No.: L656183 Peso molecular: 511.70 PubChem CID: 25167017

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity

In Vitro

Litronesib (LY2523355) is a selective Eg5 inhibitor. Litronesib (25 nM) induces cancer cells to death during mitotic arrest, and this needs sustained activation of spindle-assembly checkpoint (SAC). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) shows antitumor activity in a dose-dependently, and causes a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Eg5

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Mecanismo de acción

Kinesin-like protein 1 inhibitor

Propiedades del producto

• ALogP: 3.1

Nombres e identificadores

• Isómeros SMILES: CCNCCS(=O)(=O)NC[C@@]1(N(N=C(S1)NC(=O)C(C)(C)C)C(=O)C(C)(C)C)C2=CC=CC=C2
• CAS alternativo: 910634-41-2
• PubChem CID: 25167017
• Términos de entrada MeSH: (-)-N-(4-(2,2-dimethyl-propionyl)-5-((2-ethylamino-ethanesulfonylamino)-methyl)-5- phenyl-4,5-dihydro-(1,3,4)thiadiazol-2-yl)-2,2-dimethyl-propionamide;(R)-N-(4-(2,2-dimethyl-propionyl)-5-((2-ethylamino-ethanesulfonylamino)-methyl)-5- phenyl-4,5-dihydro-(
• Peso molecular: 511.70

Objetivos asociados (humanos)

KIF11 Tchem Kinesin-like protein KIF11 (2 Activities)

Discover Target: KIF11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)