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· · COA & SDS Disponible para cada producto · Same-day shipping on in-stock items Lonafarnib - Moligand™, ≥95% , Protein farnesyltransferase inhibitor, CAS No.193275-84-2, Protein farnesyltransferase inhibitor
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95% Synonyms
1-Piperidinecarboxamide, 4-(2-(4-((11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)- | 1-Piperidinecarboxamide, 4-(2-(4-((11R-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)p
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™, ≥95% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Sinónimos
1-Piperidinecarboxamide, 4-(2-(4-((11R)-3, 10-dibromo-8-chloro-6, 11-dihydro-5H-benzo(5, 6)cyclohepta(1, 2-b)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)- | 1-Piperidinecarboxamide, 4-(2-(4-((11R-3, 10-dibromo-8-chloro-6, 11-dihydro-5H-benzo(5, 6)cyclohepta(1, 2-b)p
Especificaciones y pureza
Moligand™, ≥95%
Mecanismos bioquímicos y fisiológicos
Effective Farnesyltransferase inhibitor (IC50 = 1.9 nM). Inhibition of Ras by Farnesitization. When used with CYTOTOXIC PGP substrate, PGP transport was also inhibited (IC50 & Lt; 3 μm) and its potency and anti-cancer activity were increased. Inhibit the
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Mecanismo de acción
Protein farnesyltransferase inhibitor
Propiedades del producto Nombres e identificadores Pubchem Sid 504757317 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504757317 Sonrisas canónicas C1CN(CCC1CC(=O)N2CCC(CC2)C3C4=C(CCC5=C3N=CC(=C5)Br)C=C(C=C4Br)Cl)C(=O)N IUPAC Name 4-[2-[4-[(2R)-6,15-dibromo-13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl]piperidin-1-yl]-2-oxoethyl]piperidine-1-carboxamide InChIKey DHMTURDWPRKSOA-RUZDIDTESA-N INCHI 1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1 Isómeros SMILES C1CN(CCC1CC(=O)N2CCC(CC2)[C@@H]3C4=C(CCC5=C3N=CC(=C5)Br)C=C(C=C4Br)Cl)C(=O)N Peso molecular 638.82 Reaxy-Rn 10624770 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10624770&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Clase Benzocycloheptapyridines Subclass Not available Intermediate Tree Nodes Not available Direct Parent Benzocycloheptapyridines Alternative Parents Piperidinecarboxamides N-acylpiperidines Pyridines and derivatives Aryl bromides Aryl chlorides Benzenoids Tertiary carboxylic acid amides Heteroaromatic compounds Ureas Azacyclic compounds Hydrocarbon derivatives Organic oxides Carbonyl compounds Organobromides Organochlorides Organonitrogen compounds Organopnictogen compounds Molecular Framework Aromatic heteropolycyclic compounds Substituents Benzocycloheptapyridine - N-acyl-piperidine - Piperidinecarboxamide - 1-piperidinecarboxamide - Aryl bromide - Aryl chloride - Aryl halide - Benzenoid - Pyridine - Piperidine - Heteroaromatic compound - Tertiary carboxylic acid amide - Carboxamide group - Urea - Carbonic acid derivative - Carboxylic acid derivative - Azacycle - Organobromide - Organohalogen compound - Organooxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organochloride - Organonitrogen compound - Aromatic heteropolycyclic compound Descripción This compound belongs to the class of organic compounds known as benzocycloheptapyridines. These are aromatic compounds containing a benzene ring and a pyridine ring fused to a seven membered carbocycle. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Solubilidad Solvent:DMSO, Max Conc. mg/mL: 6.39, Max Conc. mM: 10 with gentle warming Punto de fusión (°C) 150-152°C Peso molecular 638.800 g/mol XLogP3 4.800 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3 Rotatable Bond Count 3 Exact Mass 638.048 Da Monoisotopic Mass 636.05 Da Topological Polar Surface Area 79.500 Ų Heavy Atom Count 36 Formal Charge 0 Complexity 790.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 1 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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Reconstitution Calculator Reseñas Need help choosing the grade? Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
View Moligand™ grade guide →
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