LPA2 antagonist 2 - ≥95% , CAS No.36840-10-5

CAS: 36840-10-5 Cat. No.: L650214 Peso molecular: 380.35

GRADE & PURITY ≥95%

Synonyms

4,4'-(4,4'-Biphenyldiyldiimino)bis(4-oxo-2-butenoic acid) | E,E-3-[4'-(3-Carboxy-acryloylamino)-biphenyl-4-ylcarbamoyl]-acrylic acid

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

LPA2 antagonist 2 (H2L 5226501) is a selective LPA 2 antagonist with an IC 50 of 28.3 nM and a K i of 21.1 nM. LPA2 antagonist 2 is >480-fold more selective than LPA 3 ( IC 50 of 13.85 μM)

In Vitro

Lysophosphatidic acid (LPA) is a phospholipid mediator that elicits a host of biological effects including cell proliferation, survival, motility and differentiation. LPA has been shown to regulate cancer cell invasion, metastasis, and resistance to both chemotherapeutics and radiation. LPA2 antagonist 2 (H2L 5226501) inhibits LPA 1 with an Imax of 59.0% at 30 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 28.3 nM (LPA 2 ),13.85 μM (LPA 3 )

Specifications

Sinónimos

4, 4'-(4, 4'-Biphenyldiyldiimino)bis(4-oxo-2-butenoic acid) | E, E-3-[4'-(3-Carboxy-acryloylamino)-biphenyl-4-ylcarbamoyl]-acrylic acid

Especificaciones y pureza

≥95%

Mecanismos bioquímicos y fisiológicos

LPA2 antagonist 2 (H2L 5226501) is a selective LPA 2 antagonist with an IC 50 of 28.3 nM and a K i of 21.1 nM. LPA2 antagonist 2 is >480-fold more selective than LPA 3 ( IC 50 of 13.85 μM).

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

ANTAGONIST

Pureza

≥95%

Nombres e identificadores

• Peso molecular: 380.35

Propiedades químicas y físicas

• Solubilidad: DMSO : 83.33 mg/mL (219.09 mM; Need ultrasonic)