LPA2 antagonist 2 - 10mM in DMSO , CAS No.36840-10-5

CAS: 36840-10-5 Cat. No.: L656177 Peso molecular: 380.35

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

LPA2 antagonist 2 (H2L 5226501) is a selective LPA 2 antagonist with an IC 50 of 28.3 nM and a K i of 21.1 nM. LPA2 antagonist 2 is >480-fold more selective than LPA 3 ( IC 50 of 13.85 μM)

In Vitro

Lysophosphatidic acid (LPA) is a phospholipid mediator that elicits a host of biological effects including cell proliferation, survival, motility and differentiation. LPA has been shown to regulate cancer cell invasion, metastasis, and resistance to both chemotherapeutics and radiation. LPA2 antagonist 2 (H2L 5226501) inhibits LPA 1 with an Imax of 59.0% at 30 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 28.3 nM (LPA 2 ),13.85 μM (LPA 3 )

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

LPA2 antagonist 2 (H2L 5226501) is a selective LPA 2 antagonist with an IC 50 of 28.3 nM and a K i of 21.1 nM. LPA2 antagonist 2 is >480-fold more selective than LPA 3 ( IC 50 of 13.85 μM).

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

• Peso molecular: 380.35