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Por objetivo / ruta / enfermedad
Por vías de señalización
TGF-beta/Smad
TGF-β Receptor
LY-364947 - Moligand™, 10 mM in DMSO , CAS No.396129-53-6

LY-364947 - Moligand™, 10 mM in DMSO , CAS No.396129-53-6

CAS: 396129-53-6 Cat. No.: L1496327 Peso molecular: 272.3 Número EC: 636-801-2

3 Citations COA

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LY-364947 - Moligand™, 10 mM in DMSO CAS No(396129-53-6) by Aladdin Scientific

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Disponible para pedir

GRADE & PURITY Moligand™ ? 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general Specifications Nombres e identificadores Documentation Advanced Data Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Citations of This Product Referencias Calculadoras de soluciones Reseñas

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Why this grade

Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 3 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC 50 of 59 nM, and exhibits 7-fold selectivity over TGFβR-II.

Specifications

Especificaciones y pureza

Moligand™, 10 mM in DMSO

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Nombres e identificadores

Isómeros SMILES	C1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4
WGK Alemania	3
Peso molecular	272.3
Reaxy-Rn	25226619
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25226619&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Certificados (CoA, COO, BSE/TSE y tabla de análisis)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Propiedades químicas y físicas

Punto de fusión (°C)	230°C

Citations of This Product

How to Cite Aladdin Scientific Products? Citations Search

Referencias

1. Xiong Zhang, Chen Feng, Yimao Li, Chenlin Su, Shuxin Zhao, Shengdi Su, Feng Yu, Ji LI. (2021) An investigation on nephrotoxicity of Aristolactam I induced epithelial-mesenchymal transition on HK-2 cells. TOXICON, [PMID:34391786] [10.1016/j.toxicon.2021.08.005]
2. Ji Li, Mincheng Zhang, Yong Mao, Yimao Li, Xiaoxia Zhang, Xuehan Peng, Feng Yu. (2017) The potential role of aquaporin 1 on aristolochic acid I induced epithelial mesenchymal transition on HK-2 cells. JOURNAL OF CELLULAR PHYSIOLOGY, 233 (6): (4919-4925). [PMID:29215709] [10.1002/jcp.26310]
3. Shi Yongjing, Zheng Xiaodong, Peng Hui, Xu Chenqi, Sun Rui, Tian Zhigang, Sun Haoyu, Wang Xianwei. (2024) The E3 ubiquitin ligase FBXO38 maintains the antitumor function of natural killer cells by sustaining IL-15R signaling. Cancer Immunology Research, [PMID:38990095] [10.1158/2326-6066.CIR-23-1061]

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Reseñas

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