LY2090314 - Moligand™, 10mM in DMSO , Inhibitor of glycogen synthase kinase 3 beta, CAS No.603288-22-8, Inhibitor of glycogen synthase kinase 3 beta

CAS: 603288-22-8 Cat. No.: L408214 Peso molecular: 512.53 Número EC: 110-218-9

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

LY2090314 is a potentGSK-3inhibitor forGSK-3α/βwith IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of ki
In vitro

LY2090314 selectively inhibits the activity of GSK-3 by interrupting ATP binding. LY2090314 is able to stabilize β-catenin. LY2090314 shows limited efficacy as monotherapy. LY3090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer cell lines in vitro.

In vivo

LY2090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer xenografts.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

3-(9-fluoro-2-(piperidine-1-carbonyl)-1, 2, 3, 4-tetrahydro-[1, 4]diazepino[6, 7, 1-hi]indol-7-yl)-4-(imidazo[1, 2-a]pyridin-3-yl)-1H-pyrrole-2, 5-dione

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel o

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of glycogen synthase kinase 3 beta

Propiedades del producto

• ALogP: 2.5

Nombres e identificadores

• Isómeros SMILES: C1CCN(CC1)C(=O)N2CCN3C=C(C4=CC(=CC(=C43)C2)F)C5=C(C(=O)NC5=O)C6=CN=C7N6C=CC=C7
• CAS alternativo: 603288-22-8
• Términos de entrada MeSH: 3-(9-fluoro-2-(piperidin-1-ylcarbonyl)-1,2,3,4-tetrahydro(1,4)diazepino(6,7,1-hi)indol-7-yl)-4-imidazo(1,2-a)pyridin-3-yl-1H-pyrrole-2,5-dione;LY2090314
• Peso molecular: 512.53
• Reaxy-Rn: 9826528
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9826528&ln=

Objetivos asociados (humanos)

GSK3B Tclin Glycogen synthase kinase-3 beta (7 Activities)

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3A Tclin Glycogen synthase kinase-3 alpha (3 Activities)

Discover Target: GSK3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 46 mg/mL (199.73 mM); Ethanol: 2 mg/mL (8.68 mM); Water: Insoluble