Determine the necessary mass, volume, or concentration for preparing a solution.
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≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 16 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Lycorine Lycorine (Galanthidine, Amarylline, Narcissine, Licorine, Belamarine) is a toxic crystalline alkaloid found in various Amaryllidaceae species that weakly inhibits acetylcholinesterase (AChE) and ascorbic acid biosynthesis .
In vitro
Lycorine can inhibit protein synthesis in eukaryotic cells and acetylcholinesterase activity. Lycorine could effectively arrest the cell cycle at the G2/M phase and induce apoptosis in HL-60 cells. It is able to block the KM3 cell cycle at G0/G1 phase through the down-regulation of both cyclin D1 and CDK4.
In vivo
Lycorine, when tested in the human leukemia xenograft models, appears to exhibit anti-tumor activity in vivo. It prolongs the mean survival time of SCID leukemia xenograft models. Lycorine could alleviate the infiltration of tumor cells into tissues.
Cell Research(from reference)
Concentrations:0, 0.5, 1, 5, and 10 μM
Incubation Time:24, 48, 72, and 96 h
| ALogP | 0.713 |
|---|---|
| hba_count | 2 |
| Recuento HBD | 2 |
| Pubchem Sid | 488184691 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488184691 |
| Sonrisas canónicas | C1CN2CC3=CC4=C(C=C3C5C2C1=CC(C5O)O)OCO4 |
| IUPAC Name | (1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol |
| InChIKey | XGVJWXAYKUHDOO-DANNLKNASA-N |
| INCHI | 1S/C16H17NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h3-5,11,14-16,18-19H,1-2,6-7H2/t11-,14-,15+,16+/m0/s1 |
| Isómeros SMILES | C1CN2CC3=CC4=C(C=C3[C@H]5[C@H]2C1=C[C@@H]([C@H]5O)O)OCO4 |
| Peso molecular | 287.31 |
| Reaxy-Rn | 102249 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=102249&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Alkaloids and derivatives |
| Clase | Amaryllidaceae alkaloids |
| Subclass | Lycorine-type amaryllidaceae alkaloids |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Lycorine-type amaryllidaceae alkaloids |
| Alternative Parents | Phenanthridines and derivatives Tetrahydroisoquinolines Indoles and derivatives Benzodioxoles Aralkylamines N-alkylpyrrolidines Benzenoids Trialkylamines Secondary alcohols 1,2-diols Oxacyclic compounds Azacyclic compounds Acetals Organopnictogen compounds Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Lycorine skeleton - Benzoquinoline - Phenanthridine - Quinoline - Tetrahydroisoquinoline - Benzodioxole - Indole or derivatives - Aralkylamine - Benzenoid - N-alkylpyrrolidine - Pyrrolidine - Tertiary aliphatic amine - Tertiary amine - Secondary alcohol - 1,2-diol - Organoheterocyclic compound - Azacycle - Oxacycle - Acetal - Hydrocarbon derivative - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Organic oxygen compound - Amine - Alcohol - Organopnictogen compound - Aromatic heteropolycyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as lycorine-type amaryllidaceae alkaloids. These are amaryllidaceae alkaloids compounds containing the lycorine skeleton, made up of a pyrrolo[d,e]phenanthridine ring system. |
| External Descriptors | Isoquinoline alkaloids |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
| Certificate of Analysis | Jan 19, 2026 | L413074 | |
| Certificate of Analysis | Jan 19, 2026 | L413074 | |
| Certificate of Analysis | Jan 19, 2026 | L413074 | |
| Certificate of Analysis | Jan 19, 2026 | L413074 | |
| Certificate of Analysis | Jun 07, 2025 | L413074 | |
| Certificate of Analysis | Jun 07, 2025 | L413074 | |
| Certificate of Analysis | Jun 07, 2025 | L413074 | |
| Certificate of Analysis | Jun 07, 2025 | L413074 | |
| Certificate of Analysis | Jan 03, 2023 | L413074 | |
| Certificate of Analysis | Jan 03, 2023 | L413074 |
| Solubilidad | Solubility (25°C) In vitro DMSO: 57 mg/mL (198.39 mM); |
|---|---|
| Sensibilidad | Heat sensitive |
| DMSO (mg/ml) Solubilidad máxima | 57 |
| DMSO (mM) Solubilidad máxima | 198.3919808 |
| Peso molecular | 287.310 g/mol |
| XLogP3 | 0.000 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 0 |
| Exact Mass | 287.116 Da |
| Monoisotopic Mass | 287.116 Da |
| Topological Polar Surface Area | 62.200 Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 481.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 4 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Su Jie, Huo Mengmeng, Xu Fengnan, Ding Liqiong. (2023) Molecular mechanism of lycorine in the treatment of glioblastoma based on network pharmacology and molecular docking. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, [PMID:37668687] [10.1007/s00210-023-02702-3] |
| 2. Chudin Andrey A., Zlotnikov Igor D., Krylov Sergey S., Semenov Victor V., Kudryashova Elena V.. (2023) Allylpolyalkoxybenzene Inhibitors of Galactonolactone Oxidase from Trypanosoma cruzi. BIOCHEMISTRY-MOSCOW, 88 (1): (131-141). [PMID:37068875] [10.1134/S000629792301011X] |
| 3. Su Jie, Yin Wei, Huo Mengmeng, Yao Qing, Ding Liqiong. (2023) Induction of apoptosis in glioma cells by lycorine via reactive oxygen species generation and regulation of NF-κB pathways. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 396 (6): (1247-1255). [PMID:36715733] [10.1007/s00210-023-02384-x] |
| 4. Guosong Xin, Miao Yu, Yang Hu, Shiyong Gao, Zheng Qi, Yuan Sun, Wenjing Yu, Jiaxin He, Yubin Ji. (2020) Effect of lycorine on the structure and function of hepatoma cell membrane in vitro and in vivo. BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT, [PMID:] [10.1080/13102818.2020.1719019] |
| 5. Yu-Mei Zhao, Lv-Huan Wang, Si-Fan Luo, Qi-Qin Wang, Ruin Moaddel, Ting-Ting Zhang, Zheng-Jin Jiang. (2018) Magnetic beads-based neuraminidase enzyme microreactor as a drug discovery tool for screening inhibitors from compound libraries and fishing ligands from natural products. JOURNAL OF CHROMATOGRAPHY A, [PMID:30005943] [10.1016/j.chroma.2018.07.031] |
| 6. J.J. Nair, J. Van Staden. (2018) Caspase-inducing effects of lycorane and crinane alkaloids of the Amaryllidaceae. SOUTH AFRICAN JOURNAL OF BOTANY, [PMID:] [10.1016/j.sajb.2018.05.016] |
| 7. Dong Zhu, Zhao Yi Miao, Rui Xiang Yang, Hong Mei Wen, Wei Li, Jun Chen, An Kang, Chen-Xiao Shan, Sheng Yu, Yue Hu. (2016) Layer-by-layer functionalized porous Zinc sulfide nanospheres-based solid-phase extraction combined with liquid chromatography time-of-flight/mass and gas chromatography-mass spectrometry for the specific enrichment and identification of alkaloids from Crinum asiaticum var. sinicum. ANALYTICA CHIMICA ACTA, [PMID:27286770] [10.1016/j.aca.2016.05.028] |
| 8. Qing Wang, Ling Tong, Lin Yao, Peng Zhang, Li Xu. (2016) Fingerprinting of traditional Chinese medicines on the C18-Diol mixed-mode column in online or offline two-dimensional liquid chromatography on the single column modes. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, [PMID:27031576] [10.1016/j.jpba.2016.03.033] |
| 9. Qing Wang, Yao Long, Lin Yao, Li Xu, Zhi-Guo Shi, Lanying Xu. (2015) Preparation, characterization and application of a reversed phase liquid chromatography/hydrophilic interaction chromatography mixed-mode C18-DTT stationary phase. TALANTA, [PMID:26695288] [10.1016/j.talanta.2015.09.009] |
| 10. Qing Wang, Zhi-Yuan Luo, Mao Ye, Yu-Zhuo Wang, Li Xu, Zhi-guo Shi, Lanying Xu. (2015) Preparation, chromatographic evaluation and application of adenosine 5′-monophosphate modified ZrO2/SiO2 stationary phase in hydrophilic interaction chromatography. JOURNAL OF CHROMATOGRAPHY A, [PMID:25627970] [10.1016/j.chroma.2015.01.017] |
| 11. Jingjing Kang, Yushun Zhang, Xiang Cao, Jie Fan, Guilan Li, Qi Wang, Ying Diao, Zhihui Zhao, Lan Luo, Zhimin Yin. (2011) Lycorine inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in RAW264.7 cells through suppressing P38 and STATs activation and increases the survival rate of mice after LPS challenge. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:22155741] [10.1016/j.intimp.2011.11.018] |
| 12. Jerald J. Nair, Johannes van Staden. (2024) Anti-inflammatory Principles of the Plant Family Amaryllidaceae. PLANTA MEDICA, [PMID:39029914] [10.1055/a-2369-8104] |
| 13. Qinbing Xue, Bing Wang, Jie Feng, Chaoyu Li, Miao Yu, Yan Zhao, Zheng Qi. (2024) Lycorine (Lycoris radiata)—a unique natural medicine on breast cancer. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 28 (16): (e70032). [PMID:39175104] [10.1111/jcmm.70032] |
| 14. Qing Wang, Jie Chen, Kun Huang, Xin Zhang, Li Xu, Zhi-guo Shi. (2014) Preparation, characterization and application of N-methylene phosphonic acid chitosan grafted magnesia–zirconia stationary phase. ANALYTICA CHIMICA ACTA, [PMID:25479884] [10.1016/j.aca.2014.11.022] |
| 15. Liyun Ma, Si-Min Liu, Lin Yao, Li Xu. (2014) Preparation and chromatographic performance evaluation of cucurbit[7]uril immobilized silica. JOURNAL OF CHROMATOGRAPHY A, [PMID:25528071] [10.1016/j.chroma.2014.12.002] |
| 16. Shengjin Zhou, Gang Chen, Bing Wang, Qinbing Xue, Hao Wang, Ting Liu, Siyu Chen, Chunna Wang, Zheng Qi, Miao Yu, Ning Kang. (2026) Lycorine from Lycoris radiata induces M phase arrest in breast cancer by targeting miR-203a-3p-mediated MAPK signaling pathway. Chinese Herbal Medicines, [PMID:] [10.1016/j.chmed.2026.03.002] |