m-PEG-NHS ester - MW5000 , CAS No.92451-01-9

CAS: 92451-01-9 Cat. No.: M658882 Peso molecular: 293.27 PubChem CID: 71312614

GRADE & PURITY MW5000

Synonyms

Methoxypolyethylene glycol 5,000 acetic acid N-succinimidyl ester | mono-Methyl polyethylene glycol 5′000 acetic acid N-succinimidyl ester | Succinimidyl ester of carboxymethyl-PEG | mPEG-SC (MW 5000) | mPEG-Succinimidyl ester (MW 5000)

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

The m-PEG-NHS ester (MW 5000) is a PROTAC linker belonging to the PEG class. It can be used to synthesize PROTAC molecules

m-PEG-NHS ester (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Appearance:Solid

IC50& Target:PEGs Alkyl/ether

In Vitro:PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. MCE

Biological Activity:m-PEG-NHS ester (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Specifications

Sinónimos

Methoxypolyethylene glycol 5, 000 acetic acid N-succinimidyl ester | mono-Methyl polyethylene glycol 5′000 acetic acid N-succinimidyl ester | Succinimidyl ester of carboxymethyl-PEG | mPEG-SC (MW 5000) | mPEG-Succinimidyl ester (MW 5000)

Especificaciones y pureza

MW5000

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nombres e identificadores

• Sonrisas canónicas: COCCO.C1CC(=O)N(C1=O)OC(=O)COCCO
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 2-(2-hydroxyethoxy)acetate;2-methoxyethanol
• InChIKey: NYXRHTOXAYVBMV-UHFFFAOYSA-N
• INCHI: 1S/C8H11NO6.C3H8O2/c10-3-4-14-5-8(13)15-9-6(11)1-2-7(9)12;1-5-3-2-4/h10H,1-5H2;4H,2-3H2,1H3
• Isómeros SMILES: COCCO.C1CC(=O)N(C1=O)OC(=O)COCCO
• WGK Alemania: 3
• PubChem CID: 71312614
• Peso molecular: 293.27

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Pyrrolidines
      • Subclass Pyrrolidones

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Pyrrolidines
• Subclass: Pyrrolidones
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyrrolidine-2-ones
• Alternative Parents: Dicarboximides Lactams Monocarboxylic acids and derivatives Dialkyl ethers Azacyclic compounds Primary alcohols Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Not available
• Substituents: 2-pyrrolidone - Dicarboximide - Lactam - Carboxylic acid derivative - Dialkyl ether - Ether - Monocarboxylic acid or derivatives - Azacycle - Organonitrogen compound - Alcohol - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Organooxygen compound - Primary alcohol - Organic oxide - Hydrocarbon derivative - Aliphatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as pyrrolidine-2-ones. These are pyrrolidines which bear a C=O group at position 2 of the pyrrolidine ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Sensibilidad: Light Sensitive；Moisture Sensitive