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MA(PEG)12 Methyl-PEG-Amine Compound , CAS No.M638939
Disponible para pedir
Storage
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
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Why this grade
for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
Product introduction：
MA(PEG)12 is a methyl- and amine-terminated polyethylene glycol reagent that is useful for a variety of surface-modification and molecule-pegylation applications.
Features of MA(PEG)12:
• Fully characterized PEGylation reagent with defined PEG chain length; discrete molecular weight for consistency of performance in protein-modification applications
• PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
• Allows site-specific labeling of primary amines or carboxyl groups on proteins or surfaces
• Easy-to-follow instructions increase the likelihood of a successful outcome
MA(PEG)n is the abbreviation for a set of compounds having polyethylene glycol (PEG) spacers and terminal methyl (-CH3) and amino (-NH2) groups. The unbranched, hydrophilic, discrete-length molecules have the form Methyl-PEGn-Amine, where the subscript 'n' denotes 4, 8, 12, or 24 ethylene glycol units. The terminal primary amine of each compound provides a specific target for crosslinking and other conjugation methods, making these compounds useful as PEGylation reagents.
Applications of PEGylation:
• PEGylate carboxylate or amine surfaces
• Add inert mass to proteins, immunogens, drug compounds and probes
• Improve solubility (decrease aggregation) of proteins or peptides without affecting function
• Protect proteins from proteolysis
Methods of Covalent Attachment:
• Conjugate to carboxyl groups usingreductive amination
Why PEGylate a protein or peptide?
Methyl-capped PEG-containing reagents have been used to modify proteins to provide specific advantages. Protein PEGylation can improve the stability of the modified protein, protect it from proteolytic digestion, increase its half life in a biological application, mask it from causing an immunogenic response, decrease its antigenicity or potential toxicity, improve its solubility, diminish the potential for aggregation, and minimize interference for both in vitro and in vivo applications. Polyethylene glycol, also called polyethylene oxide (PEO), has these effects because it is nontoxic, nonimmunogenic, hydrophilic, water soluble and highly flexible.
Advantages of Discrete-length Polyethylene Glycol Compounds:
These reagents are specially synthesized, resulting in homogeneous compounds of defined molecular weight, characterized by discrete chain lengths, providing a greater ability to optimize and characterize surface protein modifications. Typical preparations of PEG compounds are a heterogeneous mixtures composed of a distribution of chain lengths with a specified average molecular weight or approximate number of PEG subunits.
• Reactive Moiety:Amine,Primary Amine
• Form:Solid
• Spacer:12 ethylene glycol units
Features of MA(PEG)12:
• Fully characterized PEGylation reagent with defined PEG chain length; discrete molecular weight for consistency of performance in protein-modification applications
• PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
• Allows site-specific labeling of primary amines or carboxyl groups on proteins or surfaces
• Easy-to-follow instructions increase the likelihood of a successful outcome
MA(PEG)n is the abbreviation for a set of compounds having polyethylene glycol (PEG) spacers and terminal methyl (-CH3) and amino (-NH2) groups. The unbranched, hydrophilic, discrete-length molecules have the form Methyl-PEGn-Amine, where the subscript 'n' denotes 4, 8, 12, or 24 ethylene glycol units. The terminal primary amine of each compound provides a specific target for crosslinking and other conjugation methods, making these compounds useful as PEGylation reagents.
Applications of PEGylation:
• PEGylate carboxylate or amine surfaces
• Add inert mass to proteins, immunogens, drug compounds and probes
• Improve solubility (decrease aggregation) of proteins or peptides without affecting function
• Protect proteins from proteolysis
Methods of Covalent Attachment:
• Conjugate to carboxyl groups usingreductive amination
Why PEGylate a protein or peptide?
Methyl-capped PEG-containing reagents have been used to modify proteins to provide specific advantages. Protein PEGylation can improve the stability of the modified protein, protect it from proteolytic digestion, increase its half life in a biological application, mask it from causing an immunogenic response, decrease its antigenicity or potential toxicity, improve its solubility, diminish the potential for aggregation, and minimize interference for both in vitro and in vivo applications. Polyethylene glycol, also called polyethylene oxide (PEO), has these effects because it is nontoxic, nonimmunogenic, hydrophilic, water soluble and highly flexible.
Advantages of Discrete-length Polyethylene Glycol Compounds:
These reagents are specially synthesized, resulting in homogeneous compounds of defined molecular weight, characterized by discrete chain lengths, providing a greater ability to optimize and characterize surface protein modifications. Typical preparations of PEG compounds are a heterogeneous mixtures composed of a distribution of chain lengths with a specified average molecular weight or approximate number of PEG subunits.
• Reactive Moiety:Amine,Primary Amine
• Form:Solid
• Spacer:12 ethylene glycol units
Specifications
Condiciones de almacenamiento de almacenamiento
Store at -20°C, Desiccated
Enviado en
Ice chest + Ice pads
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Propiedades del producto
| Reactividad | Carboxylic Acid, Ketone, Aldehyde |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
| Solubilidad | Water |
|---|
Calculadoras de soluciones
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