Mangiferin - Moligand™,≥95% , CAS No.4773-96-0

CAS: 4773-96-0 Cat. No.: M196329 Peso molecular: 422.34 Número EC: 624-757-7
Disponible para pedir
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%
Synonyms
1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one | DTXCID70119754 | UNII-1M84LD0UMD | AS-15337 | 9H-Xanthen-9-one, 2-b-D-glucopyranosyl-1,3,6,7-tetrahydroxy- | NSC 248870 | Chinoinin | MANGIFERIN [USP-RS]
Storage
Store at 2-8°C
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
1g
M196329-1g
3
9,90US$
5g
M196329-5g
3
18,90US$
25g
M196329-25g
1
65,90US$
100g
M196329-100g
1
227,90US$
Enter a quantity for the sizes you want to add.
🧪

Why this grade

Moligand™,≥95% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 16 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Product Description:

Mangiferin (MGF) is a natural bioactive polyphenol predominantly isolated from the Mangifera indica (Mango) tree. It has a xanthone glucoside structure. Mangiferin can also be found in other angiosperm plants and herbs.

Product Application:

Mangiferin has been used:
as a reference standard for the characterization of mangiferin from Mangifera indica using ultrasound with three-phase partitioning (UTPP)
to study its effects in promoting brown adipose phenotype murine C3H10T1/2 mesenchymal stem cells (MSCs) and its role in mitochondrial biogenesis and homeostasis
as a reference standard for the quantitative determination of markers compounds in the culture Swertia paniculata shoot culture using high-performance thin-layer chromatography.



Specifications

Sinónimos
1, 3, 6, 7-tetrahydroxy-2-[(2S, 3R, 4R, 5S, 6R)-3, 4, 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one | DTXCID70119754 | UNII-1M84LD0UMD | AS-15337 | 9H-Xanthen-9-one, 2-b-D-glucopyranosyl-1, 3, 6, 7-tetrahydroxy- | NSC 248870 | Chinoinin | MANGIFERIN [USP-RS]
Especificaciones y pureza
Moligand™, ≥95%
Mecanismos bioquímicos y fisiológicos
Mangiferin has various pharmacological properties including antioxidant, anti-diabetic, anti-bacterial, cardioprotective, neuroprotective, and immunomodulatory activities. It has also displayed antidiabetic, antihyperlipidemic, and antiatherogenic propert
Condiciones de almacenamiento de almacenamiento
Store at 2-8°C
Enviado en
Wet ice
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Pureza
≥95%
Nombres e identificadores
Pubchem Sid504763370
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504763370
Sonrisas canónicasC1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=C(C(=C3)O)C4C(C(C(C(O4)CO)O)O)O)O
IUPAC Name1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one
InChIKeyAEDDIBAIWPIIBD-ZJKJAXBQSA-N
INCHI1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11-,15-,17+,18-,19+/m1/s1
Isómeros SMILES C1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=C(C(=C3)O)[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O
Peso molecular 422.34
Reaxy-Rn 1359328
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1359328&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClaseBenzopyrans
Subclass1-benzopyrans
Intermediate Tree Nodes Dibenzopyrans - Xanthenes
Direct ParentXanthones
Alternative Parents Phenolic glycosides  Hexoses  C-glycosyl compounds  Chromones  Pyranones and derivatives  1-hydroxy-2-unsubstituted benzenoids  1-hydroxy-4-unsubstituted benzenoids  Oxanes  Vinylogous acids  Heteroaromatic compounds  Secondary alcohols  Polyols  Oxacyclic compounds  Dialkyl ethers  Organic oxides  Primary alcohols  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Phenolic glycoside - Xanthone - Hexose monosaccharide - C-glycosyl compound - Chromone - Glycosyl compound - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Pyranone - Benzenoid - Pyran - Oxane - Monosaccharide - Heteroaromatic compound - Vinylogous acid - Secondary alcohol - Oxacycle - Polyol - Dialkyl ether - Ether - Hydrocarbon derivative - Organic oxygen compound - Organic oxide - Organooxygen compound - Primary alcohol - Alcohol - Aromatic heteropolycyclic compound
DescripciónThis compound belongs to the class of organic compounds known as xanthones. These are polycyclic aromatic compounds containing a xanthene moiety conjugated to a ketone group at carbon 9. Xanthene is a tricyclic compound made up of two benzene rings linearly fused to each other through a pyran ring.
External Descriptors xanthenes
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
AKR1B1 Tclin Aldose reductase (1404 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U2OS (164939 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NUDT1 Tchem 7,8-dihydro-8-oxoguanine triphosphatase (280 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Objetivos asociados (no humanos)
NA Neuraminidase (1107 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gusb Beta-glucuronidase (17 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human alphaherpesvirus 1 (11089 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
3T3-L1 (3664 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BHK-21 (725 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BV-2 (3710 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Genome polyprotein (620 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
nanH Sialidase (337 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal (75 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Danio rerio (3092 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

22 results found

Lot NumberCertificate TypeFechaArticulo
L2503620Certificate of AnalysisNov 13, 2025 M196329
L2503619Certificate of AnalysisNov 13, 2025 M196329
K2526499Certificate of AnalysisNov 13, 2025 M196329
K2526498Certificate of AnalysisNov 13, 2025 M196329
C2627007Certificate of AnalysisNov 13, 2025 M196329
E2606053Certificate of AnalysisNov 13, 2025 M196329
K2103097Certificate of AnalysisAug 11, 2025 M196329
H2429499Certificate of AnalysisAug 03, 2024 M196329
I2424026Certificate of AnalysisAug 03, 2024 M196329
H2501087Certificate of AnalysisAug 03, 2024 M196329
H2429505Certificate of AnalysisAug 03, 2024 M196329
H2429503Certificate of AnalysisAug 03, 2024 M196329
H2429500Certificate of AnalysisAug 03, 2024 M196329
H2429498Certificate of AnalysisAug 03, 2024 M196329
B2209177Certificate of AnalysisFeb 26, 2024 M196329
E2409022Certificate of AnalysisFeb 26, 2024 M196329
C2420055Certificate of AnalysisFeb 26, 2024 M196329
B2418187Certificate of AnalysisFeb 26, 2024 M196329
B2209252Certificate of AnalysisFeb 26, 2024 M196329
B2209178Certificate of AnalysisFeb 26, 2024 M196329
F2316119Certificate of AnalysisJun 21, 2023 M196329
D2321311Certificate of AnalysisSep 06, 2021 M196329

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Propiedades químicas y físicas
SensibilidadHeat Sensitive
Punto de fusión (°C)270 °C
Peso molecular422.300 g/mol
XLogP3-0.400
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count11
Rotatable Bond Count2
Exact Mass422.085 Da
Monoisotopic Mass422.085 Da
Topological Polar Surface Area197.000 Ų
Heavy Atom Count30
Formal Charge0
Complexity646.000
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
Referencias
1. Wanran Huang, Yanni Wang, Wei Huang.  (2023)  Mangiferin alleviates 6-OHDA-induced Parkinson's disease by inhibiting AKR1C3 to activate Wnt signaling pathway.  NEUROSCIENCE LETTERS,      [PMID:38142926] [10.1016/j.neulet.2023.137608]
2. Hang Zhou, Zhang Mao, Xiaonan Zhang, Ruomiao Li, Jian Yin, Yinghui Xu.  (2023)  Neuroprotective Effect of Mangiferin against Parkinson’s Disease through G-Protein-Coupled Receptor-Interacting Protein 1 (GIT1)-Mediated Antioxidant Defense.  ACS Chemical Neuroscience,      [PMID:37036451] [10.1021/acschemneuro.2c00458]
3. Yuhang Xing, Ruyi Li, Lu Xue, Mianhong Chen, Xuli Lu, Zhihao Duan, Wei Zhou, Jihua Li.  (2022)  Double emulsion (W/O/W) gel stabilised by polyglycerol polyricinoleate and calcium caseinate as mangiferin carrier: insights on formulation and stability properties.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  57  (8): (5268-5279).  [PMID:] [10.1111/ijfs.15856]
4. Ye Wu, Yu Wang, Linyu Long, Cheng Hu, Qingquan Kong, Yunbing Wang.  (2021)  A spatiotemporal release platform based on pH/ROS stimuli-responsive hydrogel in wound repairing.  JOURNAL OF CONTROLLED RELEASE,      [PMID:34813880] [10.1016/j.jconrel.2021.11.027]
5. Yunbo Li, Benguo Liu, Mengmeng Yu, Sheng Geng.  (2021)  High-efficiency formation mechanism of mangiferin/γ-cyclodextrin complex.  FOOD SCIENCE AND TECHNOLOGY RESEARCH,      [PMID:] [10.3136/fstr.27.735]
6. Chao Yin, Jun Zheng, Yufan Yang, Xianwen Song, Miao Cui, Rujuan Shen, Yi Zhang.  (2025)  A facile preparation strategy for multifunctional hydrogel films with adjustable performance in food preservation.  Food Packaging and Shelf Life,      [PMID:] [10.1016/j.fpsl.2025.101471]
7. Mengke Hao, Simin Wei, Siqi Su, Zhishu Tang, Yinghui Wang.  (2024)  A Multifunctional Hydrogel Fabricated by Direct Self-Assembly of Natural Herbal Small Molecule Mangiferin for Treating Diabetic Wounds.  ACS Applied Materials & Interfaces,      [PMID:38709623] [10.1021/acsami.4c01265]
8. Yanhong Bi, Ruiping Fu, Weiliang Hua, Xinyu Xiong, Chun Zhu, Xiaobao Nie, Zhaoyu Wang.  (2025)  An empirical exploration of the capacity of choline chloride/lactic acid eutectics to extract and stabilize natural polyhydroxy compounds.  FOOD CHEMISTRY,      [PMID:40120314] [10.1016/j.foodchem.2025.143873]
9. Huilin Deng, Yaozhong Zheng, Qiongyao Wang, Jiaqi Peng, Weibin Bai, Lingmin Tian, Zouyan He, Rui Jiao.  (2025)  In vitro gastrointestinal digestion and colonic fermentation of Mangiferin: Impacts on gut microbiota and metabolite profiles.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2025.106667]
10. Cheng Lu, ShiJun Deng, YanJiao Liu, ShengJin Yang, DingMei Qin, LiJuan Zhang, Rui-rui Wang, Yi Zhang.  (2024)  Inhibition of macrophage MAPK/NF-κB pathway and Th2 axis by mangiferin ameliorates MC903-induced atopic dermatitis.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:38621336] [10.1016/j.intimp.2024.112038]
11. Siyi Wang, Min Nian, Yu Ma, Xiaojia Chen, Xiaotong Ji, Changzhi Shi, Xing Chen, Mingliang Fang.  (2025)  Machine Learning-Based Screening of Cosmetic Ingredients Identifies Vat Blue 6 as a Thyroid Hormone Receptor β Disruptor.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:40668138] [10.1021/acs.est.5c04327]
12. Wei Nong, Xiaoli Chen, Yixin Chen, Xueping Feng, Wen Kong, Rui Chi, Li Yan, Zhiquan Wei.  (2025)  Natural polyphenol mangiferin delays neuronal cell senescence by inhibiting neuroinflammation mediated by microglial activation.  IBRO Neuroscience Reports,      [PMID:40271493] [10.1016/j.ibneur.2025.04.006]
13. Shuang Wang, Yuan Qin, Yashi Liu, Rui Jiao, Rui Lin, Zongxiang Yuan, Zouyan He.  (2025)  Lipid-lowering effect of mangiferin through the inhibition of pancreatic lipase activity.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,      [PMID:40265679] [10.1002/jsfa.14301]
14. Zhifeng Cai, Tianyu Miao, Guiyu Meng, Yanan Li.  (2025)  N, S-CDs for colorimetric/fluorometric dual-mode nanosensor and smartphone-based determination of curcumin in fruits.  FOOD CONTROL,      [PMID:] [10.1016/j.foodcont.2025.111515]
15. Ruoying Du, Xiaoyun Jiang, Yichen Wang, Jin Wang, Bo Si, Chun Chang, Yonglin Lu, Lishuang Lv.  (2026)  Scavenging multiple reactive carbonyl species simultaneously by mangiferin and its aglycone norathyriol in vitro and in vivo.  FOOD RESEARCH INTERNATIONAL,      [PMID:41794501] [10.1016/j.foodres.2026.118639]
16. Zhifeng Cai, Lingjie Hou, Qun Cai, Yaxuan Feng, Yiran Zhang, Yuqi Zhang.  (2026)  Determination of mangiferin via a smartphone-assisted fluorescence system with blue-emitting carbon quantum dots.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2026.139930]
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