Melanin - Moligand™, Synthetic , CAS No.8049-97-6

CAS: 8049-97-6 Cat. No.: M329644 Peso molecular: 318.29 Número EC: 232-473-6

GRADE & PURITY Moligand™, Synthetic

Synonyms

6,14-dimethyl-4,12-diazapentacyclo[8.6.1.12,5.013,17.09,18]octadeca-1(17),2,5,9(18),10,13-hexaene-7,8,15,16-tetrone | Phaeomelanins

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Melanin is a vital pigment present on the surface structures of vertebrates, which contribute to skin color. It has three forms such as, eumelanin, pheomelanin and neuromelanin. Melanin has cation chelating and redox properties. It is a potent absorbent of light. Melanin functions as a chemoprotective and photoprotective pigment. Mutations in this gene are associated with oculocutaneous albinism, vitiligo, piebaldism and Waardenburg syndrome. 

Specifications

Sinónimos

6, 14-dimethyl-4, 12-diazapentacyclo[8.6.1.12, 5.013, 17.09, 18]octadeca-1(17), 2, 5, 9(18), 10, 13-hexaene-7, 8, 15, 16-tetrone | Phaeomelanins

Especificaciones y pureza

Moligand™, Synthetic

Mecanismos bioquímicos y fisiológicos

Melanin removes reactive chemicals and is used as a sunscreen.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Nombres e identificadores

• Pubchem Sid: 504764038
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504764038
• Sonrisas canónicas: CC1=C2C3=C(C4=CNC5=C(C(=O)C(=O)C(=C45)C3=CN2)C)C(=O)C1=O
• IUPAC Name: 6,14-dimethyl-4,12-diazapentacyclo[8.6.1.12,5.013,17.09,18]octadeca-1(17),2,5,9(18),10,13-hexaene-7,8,15,16-tetrone
• InChIKey: XUMBMVFBXHLACL-UHFFFAOYSA-N
• INCHI: 1S/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3
• Isómeros SMILES: CC1=C2C3=C(C4=CNC5=C(C(=O)C(=O)C(=C45)C3=CN2)C)C(=O)C1=O
• WGK Alemania: 1
• CAS alternativo: 8049-97-6
• Términos de entrada MeSH: Allomelanins;Melanin;Melanins;Phaeomelanins
• Peso molecular: 318.29
• Reaxy-Rn: 27883843
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=27883843&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Anthracenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Anthracenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Anthracenes
• Alternative Parents: Indolequinones Isoindoles Indoles Quinones Vinylogous amides Pyrroles Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Anthracene - Indolequinone - Indole - Indole or derivatives - Isoindole - Isoindole or derivatives - Quinone - Vinylogous amide - Pyrrole - Heteroaromatic compound - Cyclic ketone - Organoheterocyclic compound - Azacycle - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as anthracenes. These are organic compounds containing a system of three linearly fused benzene rings.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (no humanos)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in 1% hydrogen peroxide(pH 10) (1 mg/ml).
• Peso molecular: 318.300 g/mol
• XLogP3: -1.200
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 0
• Exact Mass: 318.064 Da
• Monoisotopic Mass: 318.064 Da
• Topological Polar Surface Area: 92.300 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 984.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Wenjing Ma, Wenxuan Cao, Min Cui, Haifeng Lu, Ranhua Xiong, Chaobo Huang.  (2023)  Biomass-derived 3D evaporator with antifouling and salt-rejecting toward solar-enabled steam generation, desalination, and electricity generation.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.147404]

2. Qi Yang, Huan Yu, Yiling Qu, Xiaochun Zhang, Ruocheng Xia, Ziwei Wang, Rui Tan, Lei Xiong, Shihan Xi, Jun Wu, Yuzhen Gao, Suhua Zhang, Chengtao Li.  (2022)  Developmental validation of the novel six-dye GoldeneyeTM DNA ID System 35InDel kit for forensic application.  Forensic Sciences Research,      [PMID:36817233] [10.1080/20961790.2021.1945723]

3. Vivian Andoh, Liang Chen, Feifei Zhu, Qi Ge, Lin Ma, Qiang Wang, Keping Chen.  (2022)  The Evaluation of the Biological Effects of Melanin by Using Silkworm as a Model Animal.  Toxins,  14  (7): (421).  [PMID:35878159] [10.3390/toxins14070421]

4. Yu Li, Jianrong Wu, Gareth R. Williams, Shiwei Niu, Jianfeng Zhou, Yanbo Yang, Xuejing Zhang, Zi Fu, Dejian Li, Li-Min Zhu.  (2019)  Synergistic Chemo-Photothermal Suppression of Cancer by Melanin Decorated MoOx Nanosheets.  ACS Applied Bio Materials,      [PMID:35021449] [10.1021/acsabm.9b00600]

5. Zhiqiang Fang, Yangkai Xiong, Lei Huang, Jipeng Li, Daxiong Hu, Qitong Mao, Hao Jiang, Xuewei Tang, Panpan Tang, Zheng Li, Guoqing Wang.  (2024)  NIR-triggered self-healing SiO2/melanin coatings with enhanced corrosion-resistant and mechanical robustness.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.151273]