Melflufen hydrochloride - ≥99% , DNA cross-linking agent, CAS No.380449-54-7, DNA cross-linking agent

CAS: 380449-54-7 Cat. No.: M650548 Peso molecular: 534.88 Número EC: 817-853-7 PubChem CID: 70675838

GRADE & PURITY ≥99%

Synonyms

3412470A0V | MELPHALAN FLUFENAMIDE HYDROCHLORIDE [WHO-DD] | AKOS040758099 | Melphalan flufenamide hydrochloride [USAN] | Melphalan flufenamide hydrochloride (USAN) | ETHYL (2S)-2-((2S)-2-AMINO-3-(4-(BIS(2-CHLOROETHYL)AMINO)PHENYL)PROPANAMIDO)-3-(4-FLUOROP

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Descripción general

Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells .

In Vitro

Melflufen (Melphalan flufenamide) hydrochloride (0.5-10 μM; 24 hours) decreases viability of MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, and ANBL-6 cells in a concentration-dependent manner. Melflufen hydrochloride induces apoptosis in MM.1S cells. Melflufen hydrochloride also is a potent activator of exosome secretion. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Multiple myeloma cells: MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, ANBL-6 cells Concentration: 0.5, 1, 3, 5, 10 μM Incubation Time: 24 hours Result: A significant concentration-dependent decrease in viability of all cell lines was observed.

In Vivo

Melflufen (Melphalan flufenamide) hydrochloride (3 mg/kg; i.v.; twice-weekly for two weeks) shows anti-MM activity in xenograft mouse model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: CB-17 SCID mice (human plasmacytoma MM.1S xenograft mouse model) Dosage: 3 mg/kg Administration: 1.v.; twice-weekly for two weeks Result: Significantly inhibited MM tumor growth and prolonged survival of mice.

Form:Solid

Specifications

Sinónimos

3412470A0V | MELPHALAN FLUFENAMIDE HYDROCHLORIDE [WHO-DD] | AKOS040758099 | Melphalan flufenamide hydrochloride [USAN] | Melphalan flufenamide hydrochloride (USAN) | ETHYL (2S)-2-((2S)-2-AMINO-3-(4-(BIS(2-CHLOROETHYL)AMINO)PHENYL)PROPANAMIDO)-3-(4-FLUOROP

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irr

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C, Desiccated

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

CROSS-LINKING AGENT

Mecanismo de acción

DNA cross-linking agent

Pureza

≥99%

Nombres e identificadores

• Sonrisas canónicas: CCOC(=O)C(CC1=CC=C(C=C1)F)NC(=O)C(CC2=CC=C(C=C2)N(CCCl)CCCl)N.Cl
• IUPAC Name: ethyl (2S)-2-[[(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoyl]amino]-3-(4-fluorophenyl)propanoate;hydrochloride
• InChIKey: ZCMWSKHHXLCVHI-VROPFNGYSA-N
• INCHI: 1S/C24H30Cl2FN3O3.ClH/c1-2-33-24(32)22(16-18-3-7-19(27)8-4-18)29-23(31)21(28)15-17-5-9-20(10-6-17)30(13-11-25)14-12-26;/h3-10,21-22H,2,11-16,28H2,1H3,(H,29,31);1H/t21-,22-;/m0./s1
• Isómeros SMILES: CCOC(=O)[C@H](CC1=CC=C(C=C1)F)NC(=O)[C@H](CC2=CC=C(C=C2)N(CCCl)CCCl)N.Cl
• CAS alternativo: 380449-51-4
• PubChem CID: 70675838
• Términos de entrada MeSH: melflufen;melphalan-flufenamide;pepaxto
• Peso molecular: 534.88

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Not available
• Direct Parent: Peptides
• Alternative Parents: Phenylalanine and derivatives Alpha amino acid esters N-acyl-alpha amino acids and derivatives Alpha amino acid amides Amphetamines and derivatives Aniline and substituted anilines Dialkylarylamines Nitrogen mustard compounds Aralkylamines Fatty acid esters Fluorobenzenes Fatty amides Aryl fluorides Secondary carboxylic acid amides Carboxylic acid esters Monocarboxylic acids and derivatives Hydrocarbon derivatives Organopnictogen compounds Organic oxides Carbonyl compounds Alkyl chlorides Organochlorides Organofluorides Hydrochlorides Monoalkylamines
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Alpha peptide - Phenylalanine or derivatives - Alpha-amino acid ester - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Alpha-amino acid or derivatives - Amphetamine or derivatives - Aniline or substituted anilines - Dialkylarylamine - Nitrogen mustard - Tertiary aliphatic/aromatic amine - Fatty acid ester - Fluorobenzene - Halobenzene - Aralkylamine - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - Fatty amide - Fatty acyl - Benzenoid - Secondary carboxylic acid amide - Tertiary amine - Amino acid or derivatives - Carboxamide group - Carboxylic acid ester - Monocarboxylic acid or derivatives - Primary amine - Hydrochloride - Organic oxygen compound - Hydrocarbon derivative - Organopnictogen compound - Primary aliphatic amine - Carbonyl group - Organic nitrogen compound - Alkyl halide - Alkyl chloride - Organic oxide - Amine - Organochloride - Organofluoride - Organonitrogen compound - Organooxygen compound - Organohalogen compound - Aromatic homomonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as peptides. These are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: DMSO : 33.33 mg/mL (62.31 mM; Need ultrasonic) H2O : 1 mg/mL (1.87 mM; Need ultrasonic)
• Sensibilidad: Moisture sensitive