Determine the necessary mass, volume, or concentration for preparing a solution.
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≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 22 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
DMSA (Meso-2,3-dimercaptosuccinic acid) is a potent lead chelating agent found to be a scavenger of reactive oxygen species (ROS). Murine experiments have shown that this compound also lowers blood pressure in rat arterial hypertension via a decrease in total cell calcium levels. It has also been observed that DMSA upregulates mRNA expression of macrophage-1 antigen, L-, E-, and P-selectin, as well as causing an increase in TNFα (tumor necrosis factor-α) concentrations in murine lung. Mechanistic studies suggest that DMSA is metabolized into mixed disulfides of cysteine, which are active chelating agents.
A water-soluble chelating agent.
| ALogP | 0.1 |
|---|
| Pubchem Sid | 504760879 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504760879 |
| Sonrisas canónicas | C(C(C(=O)O)S)(C(=O)O)S |
| IUPAC Name | (2S,3R)-2,3-bis(sulfanyl)butanedioic acid |
| InChIKey | ACTRVOBWPAIOHC-XIXRPRMCSA-N |
| INCHI | 1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)/t1-,2+ |
| Isómeros SMILES | [C@@H]([C@@H](C(=O)O)S)(C(=O)O)S |
| WGK Alemania | 2 |
| RTECS | WM7650000 |
| Peso molecular | 182.22 |
| Beilstein | 1725150 |
| Reaxy-Rn | 1725149 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1725149&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Lipids and lipid-like molecules |
| Clase | Fatty Acyls |
| Subclass | Fatty acids and conjugates |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Thia fatty acids |
| Alternative Parents | Dicarboxylic acids and derivatives alpha-Mercaptocarboxylic acids Alkylthiols Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aliphatic acyclic compounds |
| Substituents | Thia fatty acid - Dicarboxylic acid or derivatives - 2-mercaptocarboxylic acid - Carboxylic acid - Carboxylic acid derivative - Alkylthiol - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Carbonyl group - Aliphatic acyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as thia fatty acids. These are fatty acid derivatives obtained by insertion of a sulfur atom at specific positions in the chain. |
| External Descriptors | dicarboxylic acid - dithiol - sulfur-containing carboxylic acid |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
| Certificate of Analysis | Feb 04, 2026 | D107254 | |
| Certificate of Analysis | Feb 04, 2026 | D107254 | |
| Certificate of Analysis | Feb 04, 2026 | D107254 | |
| Certificate of Analysis | Nov 17, 2025 | D107254 | |
| Certificate of Analysis | Nov 17, 2025 | D107254 | |
| Certificate of Analysis | Nov 17, 2025 | D107254 | |
| Certificate of Analysis | Nov 17, 2025 | D107254 | |
| Certificate of Analysis | Nov 17, 2025 | D107254 | |
| Certificate of Analysis | Nov 17, 2025 | D107254 | |
| Certificate of Analysis | Nov 17, 2025 | D107254 | |
| Certificate of Analysis | Nov 17, 2025 | D107254 | |
| Certificate of Analysis | Nov 10, 2025 | D107254 | |
| Certificate of Analysis | Sep 04, 2025 | D107254 | |
| Certificate of Analysis | May 19, 2025 | D107254 | |
| Certificate of Analysis | May 19, 2025 | D107254 | |
| Certificate of Analysis | May 19, 2025 | D107254 | |
| Certificate of Analysis | Aug 29, 2024 | D107254 | |
| Certificate of Analysis | Aug 29, 2024 | D107254 | |
| Certificate of Analysis | Aug 29, 2024 | D107254 | |
| Certificate of Analysis | Mar 09, 2022 | D107254 | |
| Certificate of Analysis | Mar 09, 2022 | D107254 |
| Solubilidad | Soluble in water, and ethanol (25 mg/ml, Colorless to Light Yellow, Clear). |
|---|---|
| Sensibilidad | air sensitive |
| Punto de fusión (°C) | 196-198°C |
| Peso molecular | 182.200 g/mol |
| XLogP3 | 0.100 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 3 |
| Exact Mass | 181.971 Da |
| Monoisotopic Mass | 181.971 Da |
| Topological Polar Surface Area | 76.600 Ų |
| Heavy Atom Count | 10 |
| Formal Charge | 0 |
| Complexity | 139.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
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| 2. Yanjun Huang, Qingdi Kong, Xiaojie Zhang, Hong Peng. (2022) DMSA-incorporated silsesquioxane-based hybrid polymer for selective adsorption of Pb(II) from wastewater. JOURNAL OF MOLECULAR LIQUIDS, [PMID:] [10.1016/j.molliq.2022.120723] |
| 3. Min Chen, Jun Wang, Qianbo Zhang, Jinsheng Zhang, Zhiming Chen, Rongguo Sun. (2022) Reversible detection of Hg(II) in pure water based on thymine modified nitrogen, sulfur co-doped carbon dots combined with antidote. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:36279800] [10.1016/j.saa.2022.121998] |
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| 5. Fan Lu, Yeling Yang, Yucheng Liu, Fubing Wang, Xinghu Ji, Zhike He. (2020) Point-of-care testing (POCT) of patients with a high concentration of uric acid by using alginate hydrogel microspheres embedded with CdZnTeS QDs and urate oxidase (Alg@QDs-UOx MSs). ANALYST, 146 (3): (949-955). [PMID:33245089] [10.1039/D0AN02029J] |
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| 10. Guobin Mao, Mingyuan Du, Xinxin Wang, Xinghu Ji, Zhike He. (2018) Simple construction of ratiometric fluorescent probe for the detection of dopamine and tyrosinase by the naked eye. ANALYST, 143 (21): (5295-5301). [PMID:30283922] [10.1039/C8AN01640B] |
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| 17. Lin Yang, Xueling Liu, Bingyue Song, Sixian Yang, Xiaojie Zhang, Chong Zhao, Yixiao Wu, Lei Zhang, Yanjun Huang. (2025) Selective adsorption of silver(I) by dimercaptosuccinic acid (DMSA) functionalized polyhedral oligomeric silsesquioxane (POSS)-based hybrid polymer: Behavior and mechanism. REACTIVE & FUNCTIONAL POLYMERS, [PMID:] [10.1016/j.reactfunctpolym.2025.106170] |
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| 19. Han Li, Shuzhen Cheng, Kai Zhou, Jiachen Zang, Zhenyu Wang, Ming Du. (2025) Carboxymethyl-β-cyclodextrin grafted chitosan embedded oyster (Crassostrea gigas) ferritin can alleviate lead-induced liver injury by oral administration. FOOD RESEARCH INTERNATIONAL, [PMID:40382035] [10.1016/j.foodres.2025.116417] |
| 20. Yuanyuan You, Wanjia Wu, Xiaoting Zheng, Hao Liu, Xiang Zhou, Ningxuan Liu, Jiajia Lu, Sike Lv, Yukang Wen, Ling Lu, Jia Tao, Bingquan Lin, Peng Zhao. (2025) The Burst Enhancement of MRI Using Magnetic Resonance Tuning Based Contrast Agents. ANALYTICAL CHEMISTRY, [PMID:41108221] [10.1021/acs.analchem.5c02870] |
| 21. Sheng-Ya Guo, Yong Zhang, Xing-Hui Chen, Yi-Wen Zhang, Bing-Bing Cao, Shi-Chang Zhu, Dao-Zong Xia. (2026) Protective role and mechanism of flavonoids from Smilax glabra Roxb. against lead-induced neurotoxicity and hematotoxicity in Danio rerio. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:] [10.1016/j.jep.2026.121472] |
| 22. Jiayu Zhang, Jinze Song, Liangliang Xie, Jiawei Li, Wenxin Liu, Alideertu Dong. (2026) A Recyclable Magnetic Nanosystem Enable Circulatory Antibacterial Strategy for Static and Dynamic Blood Disinfection. Small, [PMID:] [10.1002/smll.202514652] |