Methacycline HCl - 10mM in Water , CAS No.3963-95-9

CAS: 3963-95-9 Cat. No.: M407975 Peso molecular: 478.88 Beilstein Registry Number: 5470951 Número EC: 223-568-3

GRADE & PURITY 10mM in Water

Synonyms

Rondomycin | (4S,​4aR,​5S,​5aR,​12aS)​- 4-​(dimethylamino)​-​1,​4,​4a,​5,​5a,​6,​11,​12a-​octahydro-​3,​5,​10,​12,​12a-​pentahydroxy-​6-​methylene-​1,​11-​dioxo-​2-​naphthacenecarboxami​de, hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Methacycline HCl Methacycline HCl (Rondomycin) is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections.
In vitro

Methacycline\xa0inhibits TGF-β1-induced α-smooth muscle actin, Snail1, and collagen I of primary alveolar epithelial cells. Methacycline inhibits TGF-β1-induced non-Smad pathways, including c-Jun N-terminal kinase, p38, and Akt activation, but not Smad or β-catenin transcriptional activity. Methacycline has no effect on baseline c-Jun N-terminal kinase, p38, or Akt activities or lung fibroblast responses to TGF-β1.

In vivo

Methacycline\xa0(100 mg/kg, i.p.) delivered daily beginning 10 days after intratracheal bleomycin improves survival at Day 17. Methacycline attenuates Bleomycin-induced canonical EMT markers, Snail1, Twist1, collagen I, as well as fibronectin protein and mRNA. Methacycline\xa0does not attenuate inflammatory cell accumulation or alter TGF-β1-responsive genes in alveolar macrophages.\xa0
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Rondomycin | (4S, ​4aR, ​5S, ​5aR, ​12aS)​- 4-​(dimethylamino)​-​1, ​4, ​4a, ​5, ​5a, ​6, ​11, ​12a-​octahydro-​3, ​5, ​10, ​12, ​12a-​pentahydroxy-​6-​methylene-​1, ​11-​dioxo-​2-​naphthacenecarboxami​de, hydrochloride (1:1)

Especificaciones y pureza

10mM in Water

Mecanismos bioquímicos y fisiológicos

Methacycline HCl (Rondomycin) is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

• Isómeros SMILES: CN(C)[C@H]1[C@@H]2[C@H]([C@@H]3C(=C)C4=C(C(=CC=C4)O)C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O.Cl
• Peso molecular: 478.88
• Beilstein: 5470951
• Reaxy-Rn: 25461541
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25461541&ln=

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 100 mg/mL (139.12 mM); Water: Insoluble; Ethanol: Insoluble
• Punto de fusión (°C): >190°C

Referencias

1. Wanliang Liao, Yang Xu, Dingyun Li, Yixing Ye, Yuhan Ning, Weiping Wang, Ai-jun Wang.  (2022)  Facile room temperature synthesis of a NiFe2O4-based magnetic covalent organic framework for the extraction of tetracycline residues in environmental water samples prior to HPLC.  Analytical Methods,  14  (47): (4938-4946).  [PMID:36421069] [10.1039/D2AY01226J]