Methyllycaconitine citrate (MLA) - Moligand™,≥98% , CAS No.112825-05-5

CAS: 112825-05-5 Cat. No.: M275325 Peso molecular: 874.92 PubChem CID: 23514480

GRADE & PURITY Moligand™, ≥98%

Synonyms

[1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diolcitrate

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Descripción general

Product description：

Methyllycaconitine citrate is a specific antagonist of α7 neuronal nicotinic acetylcholine receptor (α7nAChR). 

Application：

Methyllycaconitine citrate salt has been used as an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist:
to study its effects on inflammatory response in rats post nicotine treatment；
to block the activity of galantamine；
to study its effects on the hepatic branch of the vagus nerve (hVNS) in rats.

Specifications

Sinónimos

[1α, 4(S), 6β, 14α, 16β]-20-Ethyl-1, 6, 14, 16-tetramethoxy-4-[[[2-(3-methyl-2, 5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7, 8-diolcitrate

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

Potent, selective antagonist at α7-containing nicotinic receptors. Also available in simple stock solutions add 1 ml of water to get an exact, ready-to-use concentration.Methyllycaconitine (MLA) is an α7 nicotinic acetylcholine receptor (α7 nAChR) antagon

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504769422
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504769422
• Sonrisas canónicas: CCN1CC2(CCC(C34C2C(C(C31)(C5(CC(C6CC4C5C6OC)OC)O)O)OC)OC)COC(=O)C7=CC=CC=C7N8C(=O)CC(C8=O)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
• IUPAC Name: (11-ethyl-8,9-dihydroxy-4,6,16,18-tetramethoxy-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-13-yl)methyl 2-(3-methyl-2,5-dioxopyrrolidin-1-yl)benzoate;2-hydroxypropane-1,2,3-tricarboxylic acid
• InChIKey: INBLZNJHDLEWPS-UHFFFAOYSA-N
• INCHI: 1S/C37H50N2O10.C6H8O7/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-11,19,21-22,24-25,27-30,33,43-44H,7,12-18H2,1-6H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
• Isómeros SMILES: CCN1CC2(CCC(C34C2C(C(C31)(C5(CC(C6CC4C5C6OC)OC)O)O)OC)OC)COC(=O)C7=CC=CC=C7N8C(=O)CC(C8=O)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
• CAS alternativo: 351344-10-0
• PubChem CID: 23514480
• Peso molecular: 874.92

Propiedades químicas y físicas

• Solubilidad: Soluble in water to 100 mM
• Sensibilidad: Moisture sensitive

Referencias

1. Tingjun Liu, Ziying You, Fangyuan Shen, Puying Yang, Junyu Chen, Shuhuai Meng, Chenglin Wang, Ding Xiong, Chengjia You, Zhenming Wang, Yu Shi, Ling Ye.  (2024)  Tricarboxylic Acid Cycle Metabolite-Coordinated Biohydrogels Augment Cranial Bone Regeneration Through Neutrophil-Stimulated Mesenchymal Stem Cell Recruitment and Histone Acetylation-Mediated Osteogenesis.  ACS Applied Materials & Interfaces,      [PMID:38284176] [10.1021/acsami.3c15473]