Methylprednisolone (NSC-19987) - Moligand™, 10mM in DMSO , Glucocorticoid receptor agonist, CAS No.83-43-2, Glucocorticoid receptor agonist

CAS: 83-43-2 Cat. No.: M409026 Peso molecular: 374.47 Beilstein Registry Number: 2340300 Número EC: 201-476-4

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(6α,​11β)​-11,​17,​21-​trihydroxy-​6-​methyl-pregna-​1,​4-​diene-​3,​20-​dione | (6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one | U 7532

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Methylprednisolone (NSC-19987) Methylprednisolone (NSC-19987) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical
In vitro

Methylprednisolone (2-10 mg/kg) markedly inhibits TNF production but does not affect serum levels of IL-10, while a high methylprednisolone dose (50 mg/kg) increases LPS-induced IL-10 levels. Methylprednisolone(from 0.01 to 100 mg/mL) also increases the biosynthesis of IL-10 by LPS-activated mouse peritoneal macrophages.

In vivo

Methylprednisolone decreases RGC survival in rats with electrophysiologically diagnosed optic neuritis. Methylprednisolone decreases RGC survival by a nongenomic, calcium-dependent mechanism. Methylprednisolone-induced enhancement of RGC degeneration depends on calcium influx through voltage-gated calcium channels. Methylprednisolone treatment leads to a significant decrease in the number of ED1-positive cells in both rostral and caudal stumps. Methylprednisolone treatment results in a significant reduction in tissue loss in both cord stumps at 2, 4 and 8 week post-injury. Methylprednisolone leads to a long-term reduction of ED1-positive cells and spinal tissue loss, reduced dieback of vestibulospinal fibres, and a transient sprouting of vestibulospinal fibres near the lesion at 1 and 2 weeks post-lesion. Methylprednisolone at a dose of 30 mg/kg which has been shown to be effective in improving functional outcomes in rat SCI models, suppresses TNF-α expression and NF-kB activation. Methylprednisolone inhibition of NF-kB function is likely mediated by the induction of IkB, which traps NF-kB in inactive cytoplasmic complexes.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥97%

Specifications

Sinónimos

(6α, ​11β)​-11, ​17, ​21-​trihydroxy-​6-​methyl-pregna-​1, ​4-​diene-​3, ​20-​dione | (6S, 8S, 9S, 10R, 11S, 13S, 14S, 17R)-11, 17-dihydroxy-17-(2-hydroxyacetyl)-6, 10, 13-trimethyl-7, 8, 9, 11, 12, 14, 15, 16-octahydro-6H-cyclopenta[a]phenanthren-3-one | U 7532

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Methylprednisolone (NSC-19987) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone mar

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

AGONIST

Mecanismo de acción

Glucocorticoid receptor agonist

Propiedades del producto

• ALogP: 1.9

Nombres e identificadores

• Isómeros SMILES: C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O
• WGK Alemania: 2
• RTECS: TU4146000
• Peso molecular: 374.47
• Beilstein: 2340300
• Reaxy-Rn: 3463507
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3463507&ln=

Objetivos asociados (humanos)

NR3C1 Tclin Glucocorticoid receptor (3 Activities)

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPC5 Tchem Short transient receptor potential channel 5 (1 Activities)

Discover Target: TRPC5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Sensibilidad: Light sensitive
• Rotación específica [α]: 82° (C=1,Dioxane)
• Punto de fusión (°C): 237°C(lit.)

Referencias

1. Fan Xinyu, Zhang Ying, Li Xinyu, Ding Junhui, Huang Jiaolong, Lian Kai, Duan Peng, Hu Chunhui, Xu Junchang.  (2025)  Unraveling Ginsenoside Rg1’s osteoprotective pathways in zebrafish models of glucocorticoid induced osteoporosis via transcriptomics.  Scientific Reports,  15  (1): (1-13).  [PMID:40835685] [10.1038/s41598-025-15284-2]

2. Yuan Liang, Zhuolin Li, Jie Zhang, Tiezhu Li, Chengyu Lv.  (2023)  Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects.  CHEMISTRY & BIODIVERSITY,      [PMID:38129310] [10.1002/cbdv.202301525]

3. Huang Suiyuan, Sun Xuehua, Xin Jianwei, Ma Panpan, Zhang Yuqi, Cai Zhongyu, Wang Ji-Jiang.  (2025)  Molecularly imprinted hydrogels embedded with two-dimensional photonic crystals for the detection of dexamethasone/betamethasone sodium phosphate.  MICROCHIMICA ACTA,  192  (2): (1-11).  [PMID:39878789] [10.1007/s00604-025-06981-w]

4. Taoyang Yuan, Weijie Liu, Tianyou Wang, Feng Ye, Jianhua Zhang, Zhipeng Gu, Jianguo Xu, Yiwen Li.  (2024)  Natural Polyphenol Delivered Methylprednisolone Achieve Targeted Enrichment for Acute Spinal Cord Injury Therapy.  Small,      [PMID:39105462] [10.1002/smll.202404815]

5. Mingyu Cui, Suiyuan Huang, Jianwei Xin, Panpan Ma, Liping Heng, Yuqi Zhang, Ji-Jiang Wang.  (2025)  Molecularly Imprinted Chitosan-Polyvinyl Alcohol Two-Dimensional Photonic Hydrogel for Detecting Hormones.  Advanced Materials Technologies,      [PMID:] [10.1002/admt.202501904]