Mexiletine HCl - ≥98%(HPLC) , Sodium channel alpha subunit blocker, CAS No.5370-01-4, Sodium channel alpha subunit blocker

CAS: 5370-01-4 Cat. No.: M129606 Peso molecular: 215.72 Número EC: 226-362-1

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Mexiletine HCl - ≥98%(HPLC) CAS No(5370-01-4) by Aladdin Scientific

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Disponible para pedir

GRADE & PURITY ≥98%(HPLC)

Synonyms

2-PROPANAMINE, 1-(2,6-DIMETHYLPHENOXY)-, HYDROCHLORIDE (1:1) | CHEBI:6917 | EU-0100784 | M2040 | Mexiletine hydrochloride | NSC758639 | NSC-758639 | UNII-606D60IS38 | MFCD18379556 | Tox21_111249_1 | KO1173 | KO-1173 | Mexiletine Hydrochloride; 1-(2,6-Xyly

Storage

Store at 2-8°C

Shipped In

Wet ice

Descripción general Specifications Nombres e identificadores Documentation Advanced Data Taxonomic Classification Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Calculadoras de soluciones Reseñas

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Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

A use dependent blocker of sodium channels.

1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (Mexiletine) is an anti-arrhythmic agent having local anaesthetic activity. Mexiletine belongs to the triclinc crystal system, with the asymmetric unit containing two independent molecules.

Specifications

Sinónimos

2-PROPANAMINE, 1-(2, 6-DIMETHYLPHENOXY)-, HYDROCHLORIDE (1:1) | CHEBI:6917 | EU-0100784 | M2040 | Mexiletine hydrochloride | NSC758639 | NSC-758639 | UNII-606D60IS38 | MFCD18379556 | Tox21_111249_1 | KO1173 | KO-1173 | Mexiletine Hydrochloride; 1-(2, 6-Xyly

Especificaciones y pureza

≥98%(HPLC)

Mecanismos bioquímicos y fisiológicos

Mexiletine hydrochloride is a use dependent blocker of sodium channels in skeletal muscle tissue. In addition, mexiletine can plays an important role in protecting neuronal tissue from oxidative damage. The aryloxy moiety of mexiletine is very important t

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

BLOCKER

Mecanismo de acción

Sodium channel alpha subunit blocker

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥98%(HPLC)

Nombres e identificadores

Pubchem Sid	504753037
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504753037
Sonrisas canónicas	CC1=C(C(=CC=C1)C)OCC(C)N.Cl
IUPAC Name	1-(2,6-dimethylphenoxy)propan-2-amine;hydrochloride
InChIKey	NFEIBWMZVIVJLQ-UHFFFAOYSA-N
INCHI	1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H
Isómeros SMILES	CC1=C(C(=CC=C1)C)OCC(C)N.Cl
RTECS	KR9310000
Peso molecular	215.72
Reaxy-Rn	4209895
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4209895&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Clase Phenol ethers

Kingdom	Organic compounds
Superclass	Benzenoids
Clase	Phenol ethers
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Phenol ethers
Alternative Parents	m-Xylenes Phenoxy compounds Alkyl aryl ethers Organopnictogen compounds Monoalkylamines Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Phenoxy compound - Phenol ether - M-xylene - Xylene - Alkyl aryl ether - Monocyclic benzene moiety - Ether - Hydrochloride - Primary amine - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Organic nitrogen compound - Organic oxygen compound - Amine - Hydrocarbon derivative - Aromatic homomonocyclic compound
Descripción	This compound belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring.
External Descriptors	hydrochloride
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estructura 3D

Objetivos asociados (humanos)

SCN1A Tclin Sodium channel protein type I alpha subunit (483 Activities)

Discover Target: SCN1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SCN5A Tclin Sodium channel protein type V alpha subunit (3462 Activities)

Discover Target: SCN5A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LMNA Tbio Prelamin-A/C (36751 Activities)

Discover Target: LMNA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 Activities)

Discover Target: MPHOSPH8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Scn9a Sodium channel protein type IX alpha subunit (69 Activities)

Discover Target: Scn9a

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pseudomonas aeruginosa (123386 Activities)

Lot Number	Certificate Type	Fecha	Articulo
A2506258	Certificate of Analysis	Apr 20, 2026	M129606
I2518828	Certificate of Analysis	Jun 26, 2024	M129606
C2209043	Certificate of Analysis	Dec 18, 2023	M129606
C2209068	Certificate of Analysis	Dec 18, 2023	M129606
K2105418	Certificate of Analysis	Aug 08, 2023	M129606
G1517291	Certificate of Analysis	Feb 03, 2023	M129606

Solubilidad	Soluble in methanol (50 mg/ml), water (100 mM), DMSO (100 mM), chloroform, and alcohol.
Punto de fusión (°C)	200-205 °C
Peso molecular	215.720 g/mol
XLogP3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Exact Mass	215.108 Da
Monoisotopic Mass	215.108 Da
Topological Polar Surface Area	35.300 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	139.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2