Microcystin-WR - 10ug/ml in methanol , CAS No.138234-58-9

CAS: 138234-58-9 Cat. No.: M299662 Peso molecular: 1068.22 PubChem CID: 101619976

GRADE & PURITY 10ug/ml in methanol

Synonyms

HY-N11681 | Microcystin-WR | Microcystin WR | DTXSID101016178 | MC-WR | (5R,8S,11R,12S,15S,18S,19S,22R)-15-[3-(diaminomethylideneamino)propyl]-8-(1H-indol-3-ylmethyl)-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,5,12,19-tetramethyl

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Product introduction：

Microcystins (MCs) are hepatotoxic cyclic heptapeptides, produced by various cyanobacterial species. MC’s cause adverse effects on freshwater systems with algae blooms.

Microcystin WR contains tryptophane (W) in position 2 and arginine (R) in position 4.Microcystins are potent inhibitors of protein phosphatase types 1 and 2A (IC50 value of MC-WR for inhibiting PP2A = 0.18 nM). No effects on protein kinases are known. MCs are known to be hepatic tumor promoters in experimental animal models.

Specifications

Sinónimos

HY-N11681 | Microcystin-WR | Microcystin WR | DTXSID101016178 | MC-WR | (5R, 8S, 11R, 12S, 15S, 18S, 19S, 22R)-15-[3-(diaminomethylideneamino)propyl]-8-(1H-indol-3-ylmethyl)-18-[(1E, 3E, 5S, 6S)-6-methoxy-3, 5-dimethyl-7-phenylhepta-1, 3-dienyl]-1, 5, 12, 19-tetramethyl

Especificaciones y pureza

10ug/ml in methanol

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nombres e identificadores

• Sonrisas canónicas: CC1C(NC(=O)C(NC(=O)C(C(NC(=O)C(NC(=O)C(NC(=O)C(=C)N(C(=O)CCC(NC1=O)C(=O)O)C)C)CC2=CNC3=CC=CC=C32)C(=O)O)C)CCCN=C(N)N)C=CC(=CC(C)C(CC4=CC=CC=C4)OC)C
• IUPAC Name: (5R,8S,11R,12S,15S,18S,19S,22R)-15-[3-(diaminomethylideneamino)propyl]-8-(1H-indol-3-ylmethyl)-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,5,12,19-tetramethyl-2-methylidene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptazacyclopentacosane-11,22-dicarboxylic acid
• InChIKey: UGNOHFGJSOFQHC-ZISXDMAXSA-N
• INCHI: 1S/C54H73N11O12/c1-29(25-30(2)43(77-8)26-35-15-10-9-11-16-35)20-21-38-31(3)46(67)62-41(52(73)74)22-23-44(66)65(7)34(6)49(70)59-33(5)48(69)63-42(27-36-28-58-39-18-13-12-17-37(36)39)51(72)64-45(53(75)76)32(4)47(68)61-40(50(71)60-38)19-14-24-57-54(55)56/h9-13,15-18,20-21,25,28,30-33,38,40-43,45,58H,6,14,19,22-24,26-27H2,1-5,7-8H3,(H,59,70)(H,60,71)(H,61,68)(H,62,67)(H,63,69)(H,64,72)(H,73,74)(H,75,76)(H4,55,56,57)/b21-20+,29-25+/t30-,31-,32-,33+,38-,40-,41+,42-,43-,45+/m0/s1
• Isómeros SMILES: C[C@H]1[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(=C)N(C(=O)CC[C@@H](NC1=O)C(=O)O)C)C)CC2=CNC3=CC=CC=C32)C(=O)O)C)CCCN=C(N)N)/C=C/C(=C/[C@H](C)[C@H](CC4=CC=CC=C4)OC)/C
• PubChem CID: 101619976
• Peso molecular: 1068.22

Propiedades químicas y físicas

• Solubilidad: Soluble in methanol or DMSO
• Sensibilidad: Soluble in methanol or DMSO