Mitomycin C - 10mM in DMSO , CAS No.50-07-7

CAS: 50-07-7 Cat. No.: M407788 Fórmula: C₁₅H₁₈N₄O₅ Peso molecular: 334.33 Beilstein Registry Number: 7231816 Número EC: 200-008-6

GRADE & PURITY 10mM in DMSO

Synonyms

KBioGR_000607 | Mytozytrex | KBio2_003175 | Mitomycin (TN) | NSC 26980 | UGN-102 | [(1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate | 50-07-7 (non-salt) | Aziri

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs,FedEx DG Service

Descripción general

Information

Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.
In vitro

Mitomycin C, by inducing DNA interstrand crosslinks, physically blocks DNA replication, recombination, and RNA transcription. ^[1] Mitomycin C potentiates TRAIL-induced apoptosis in HCT116 (p53-/-) colon cancer cells and sensitizes TRAIL-resistant colon cancer cells HT-29 to the cytokine by through JNK-independent upregulation of death receptors. ^[2] In different human cancer cell lines, such OVCAR-5 (ovary), HT-29 (colon), SK-N-MC (neuroblastoma), HEP-2 (liver), COLO-205 (colon), NIH-OVCAR-3 (ovary) and A-549 (lung) cells, Mitomycin C shows cytotoxic activity.

In vivo

As the clinical first choice in superficial bladder tumors, in a rat bladder tumor model, Mitomycin C (400 μM) significantly prevents intravesical tumor growth.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥97%

Specifications

Sinónimos

KBioGR_000607 | Mytozytrex | KBio2_003175 | Mitomycin (TN) | NSC 26980 | UGN-102 | [(1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate | 50-07-7 (non-salt) | Aziri

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs,FedEx DG Service

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Propiedades del producto

ALogP

-0.4

Nombres e identificadores

Isómeros SMILES

CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N

WGK Alemania

3

CAS alternativo

1404-00-8

Número ONU

2811

Grupo de embalaje

I

Peso molecular

334.33

Beilstein

7231816

Reaxy-Rn

630306

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=630306&ln=

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro Water: 97 mg/mL (200.25 mM); DMSO: Insoluble; Ethanol: Insoluble
• Sensibilidad: Light & Heat & Moisture sensitive
• Índice de refracción: 1.68 (Predicted)
• Punto de ebullición (°C): 581.8° C at 760 mmHg (Predicted)
• Punto de fusión (°C): 64℃

Preguntas frecuentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 50-07-7, the molecular formula is C15H18N4O5, and the molecular weight is 334.33 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.