MK-0354 - Moligand™, 10 mM in DMSO , CAS No.851776-28-8

CAS: 851776-28-8 Cat. No.: M1496018 Número EC: 635-505-0 PubChem CID: 11159621

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

MK-0354 is a partial agonist of GPR109a receptor, for hGPR109a/ mGPR109a with EC50 of 1.65/1.08 μM, showed no activation of GPR109b.IC50 value: 1.65 μM (EC50, for hGPR109a), 1.08 μM (EC50, for mGPR109a)MK-0354 is a GPR109A partial agonist that activates the antilipolytic pathway in adipocytes. The single-dose and multiple-dose pharmacokinetics and pharmacodynamics, as well as tolerability, of MK-0354 were examined in two Phase I studies conducted in healthy male volunteers. The lipid efficacy of MK-0354 was assessed in a Phase II study conducted in male and female patients with dyslipidemia.

Specifications

Especificaciones y pureza

Moligand™, 10 mM in DMSO

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

AGONIST

Nombres e identificadores

• Isómeros SMILES: C1CC2=C(C1)NN=C2C3=NNN=N3
• CAS alternativo: 851776-28-8,1934699-08-7
• PubChem CID: 11159621
• Términos de entrada MeSH: 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopentapyrazole;MK 0354;MK-0354;MK0354