ML130 (Nodinitib-1) - Moligand™, 10mM in DMSO , Inhibitor of nucleotide binding oligomerization domain containing 1;Inhibitor of nucleotide binding oligomerization domain containing 2, CAS No.799264-47-4, Inhibitor of nucleotide binding oligomerization domain containing 1;Inhibitor of nucleotide binding oligomerization domain containing 2

CAS: 799264-47-4 Cat. No.: M408340 Peso molecular: 287.34 Número EC: 804-406-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

1H-Benzimidazol-2-amine, 1-[(4-methylphenyl)sulfonyl]-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

ML130 (Nodinitib-1) ML130 (Nodinitib-1) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2.
In vitro

ML130 has shown selective inhibition of NOD1-induced NF-κB activation in HEK293 cells with no cytotoxicity and is selected as a probe candidate molecule. ML130 is also confirmed in secondary assays by selectively inhibiting NOD1-dependent IL-8 secretion and also selectively inhibiting the NOD1-dependent pathway to NF-κB activation. In another research, ML130 is proved to cause conformational changes of NOD1 in vitro and alter NOD1 subcellular targeting in cells, providing chemical probes for interrogating mechanisms regulating NOD1 activity and tools for exploring the roles of NOD1 in various infectious and inflammatory diseases.

In vivo

Cell Data

cell lines：

Concentrations：0.01 μM-50 μM

Incubation Time：24 h

Powder Purity:≥99%

Specifications

Sinónimos

1H-Benzimidazol-2-amine, 1-[(4-methylphenyl)sulfonyl]-

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

ML130 (Nodinitib-1) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of nucleotide binding oligomerization domain containing 1;Inhibitor of nucleotide binding oligomerization domain containing 2

Nombres e identificadores

• Isómeros SMILES: CC1=CC=C(C=C1)S(=O)(=O)N2C3=CC=CC=C3N=C2N
• WGK Alemania: 3
• Peso molecular: 287.34
• Reaxy-Rn: 9204175
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9204175&ln=

Objetivos asociados (humanos)

NOD2 Tclin Nucleotide-binding oligomerization domain-containing protein 2 (1 Activities)

Discover Target: NOD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CXCL8 Tchem Interleukin-8 (4 Activities)

Discover Target: CXCL8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NOD1 Tchem Nucleotide-binding oligomerization domain-containing protein 1 (10 Activities)

Discover Target: NOD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Referencias

1. Rui-qing Wang, Ying-jie He, Yuan-yuan Xiao, De-xiang Sun, Jing-hui Yang, Xiao-dong Qi, Yong Wang.  (2023)  Weavable phase change fibers with wide thermal management temperature range, reversible thermochromic and triple shape memory functions towards human thermal management.  EUROPEAN POLYMER JOURNAL,      [PMID:] [10.1016/j.eurpolymj.2023.111890]