ML385 - Moligand™, 10mM in DMSO , Inhibitor of nuclear factor; erythroid 2 like 2, CAS No.846557-71-9, Inhibitor of nuclear factor; erythroid 2 like 2

CAS: 846557-71-9 Cat. No.: M408829 Peso molecular: 511.59

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

2-(benzo[d][1,3]dioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)indolin-5-yl)thiazol-2-yl)acetamide | N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

ML385 ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. NRF2 regulates the activity of several ferroptosis and lipid peroxidation-related proteins.
In vitro

ML385 shows anti-tumor activity in NSCLC (subcutaneous and orthotopic NSCLC models) both as a single agent and in combination with carboplatin. The PK profile tested in CD-1 mice shows that ML385 has a half-life (t_1/2 = 2.82 h) after IP injection (30 mg/kg). ML385 could alleviate the pancreatic injury.

In vivo

Cell Data

cell lines：Rat leukemic cell lines RCL/0, RO/1 and K7 and human myelomonocytic leukemic U937

Concentrations：5 μM

Incubation Time：24, 48 and 72 h

Powder Purity:≥99%

Specifications

Sinónimos

2-(benzo[d][1, 3]dioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)indolin-5-yl)thiazol-2-yl)acetamide | N-[4-[2, 3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1, 3-benzodioxole-5-acetamide

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. NRF2 regulates the activity of several ferroptosis and lipid peroxidation-related proteins.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of nuclear factor; erythroid 2 like 2

Nombres e identificadores

• Isómeros SMILES: CC1=CC=CC=C1C(=O)N2CCC3=C2C=CC(=C3)C4=C(SC(=N4)NC(=O)CC5=CC6=C(C=C5)OCO6)C
• Peso molecular: 511.59
• Reaxy-Rn: 27498158
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=27498158&ln=

Objetivos asociados (humanos)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 (0 Activities)

Discover Target: NFE2L2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Referencias

1. Fan Wenbo, Zhou Jianwu.  (2023)  Icariside II Suppresses Ferroptosis to Protect Against MPP+-Induced Parkinson's Disease through Keap1/Nrf2/GPX4 Signaling.  CHINESE JOURNAL OF PHYSIOLOGY,  66  (6): (437).  [PMID:38149556] [10.4103/cjop.CJOP-D-23-00107]

2. Bing-hao Lin, Run-xun Ma, Jing-tao Wu, Shi-qi Du, Yi-yun Lv, Hao-nan Yu, Wei Zhang, Shu-ming Mao, Guang-yao Liu, Yi-tian Bu, Zi-hao Chen, Chen Jin, Zong-yi Wu, Lei Yang.  (2023)  Cinnamaldehyde Alleviates Bone Loss by Targeting Oxidative Stress and Mitochondrial Damage via the Nrf2/HO-1 Pathway in BMSCs and Ovariectomized Mice.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:37917162] [10.1021/acs.jafc.3c03501]

3. Yue Tang, Yueyue Kang, Xinru Zhang, Caiyi Cheng.  (2023)  Mesenchymal stem cell exosomes as nanotherapeutics for dry age-related macular degeneration.  JOURNAL OF CONTROLLED RELEASE,      [PMID:37028452] [10.1016/j.jconrel.2023.04.003]

4. Hengju Ge, Jiaxin Li, Yang Xu, Jiahong Xie, Naymul Karim, Fujie Yan, Jianling Mo, Wei Chen.  (2023)  Ameliorative effect of Fructus Gardeniae against lipotoxicity associated hepatocytes injury through activating Nrf2 signaling pathway.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2023.102596]

5. Yun Zhang, Maihuan Wang, Kebin Zhang, Junze Zhang, Xinpu Yuan, Guijun Zou, Zhen Cao, Chaojun Zhang.  (2022)  6′-O-Galloylpaeoniflorin attenuates Helicobacter pylori-associated gastritis via modulating Nrf2 pathway.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:35964411] [10.1016/j.intimp.2022.109122]

6. Xiao Lifang, Wang Mengyao, Li Jingjing, Wang Haoran, Pu Niu, Bo Xitong, Chen Fuxiang, Zhou Yilong, Cheng Qiong.  (2025)  Pyrroloquinoline Quinone Preconditioning Alleviates Ischemic Cerebral Injury Through Antioxidant and Anti-Inflammatory Mechanisms.  Journal of Neuroimmune Pharmacology,  20  (1): (1-15).  [PMID:40696055] [10.1007/s11481-025-10234-1]

7. Yang Tang, Zheng Wang, Feng Zhou, Ling Li, Chen Sun, Linhui Li, Fei Tang, Dongqin Huang, Zewei Li, Yang Tan, Gang Pei.  (2025)  Benzoylpaeoniflorin alleviates ulcerative colitis by inhibiting ferroptosis through targeting phosphogluconic dehydrogenase.  PHYTOMEDICINE,      [PMID:40829505] [10.1016/j.phymed.2025.157111]

8. Cong Zhang, Yangkun Xiong, Mingyang Gong, Haixia Zhao, Shan Li, Xin Chen, Xiaochuan Ye, Zhenpeng Qiu.  (2025)  Pachymic Acid Ameliorates Fructose-Driven Hyperuricemic Nephropathy in Mice by Suppressing Ferroptosis via Activating Nrf2/GPX-4 Pathway.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:40864644] [10.1021/acs.jafc.5c02398]

9. Song-Xue Yang, Wei-Lie Xiao, Xing-Jie Zhang.  (2025)  Essential oil of Saposhnikovia divaricata mitigates Cutibacterium acnes-induced inflammatory acne via Nrf2 pathway activation and NF-κB pathway inhibition.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:41015324] [10.1016/j.jep.2025.120647]

10. Xing-Jie Zhang, Yu-Kun Pu, Peng-Yun Yang, Meng-Ru Wang, Rui-Han Zhang, Xiao-Li Li, Wei-Lie Xiao.  (2024)  Isolicoflavonol ameliorates acute liver injury via inhibiting NLRP3 inflammasome activation through boosting Nrf2 signaling in vitro and in vivo.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:39366075] [10.1016/j.intimp.2024.113233]

11. Shushu Jiang, Cheng Wang, Yin Dong, Long Chen, Menghao Shi, Fengxiao Zhang, Zhaohui Wang, Minglu Liang.  (2025)  Erucin Alleviates Cardiac Hypertrophy by Improving Mitochondrial Function via Nrf2-Sirt3 Pathway.  PHYTOTHERAPY RESEARCH,      [PMID:40415605] [10.1002/ptr.8458]