ML401 - Moligand™,10mM in DMSO , CAS No.1597489-14-9

CAS: 1597489-14-9 Cat. No.: M655581 Peso molecular: 419.7 PubChem CID: 73169083

GRADE & PURITY Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183 ) with an IC 50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC 50 =6.24 nM). ML401 shows good stability and no toxicity

In Vitro

ML401 shows no toxicity (>50 μM) towards immortalized Fa2-N4 human hepatocytes and non-cytotoxic in MTT in both LnCap and IMR-32 cells (>50 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ML401 shows very good stability in both human plasma and mouse plasma . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 1.03 nM (EBI2)

Specifications

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183 ) with an IC 50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC 50 =6.24 nM). ML401 shows good stability and no toxicity.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

ANTAGONIST

Nombres e identificadores

• Isómeros SMILES: C1CN(CCN1CC2=CC=C(C=C2)Cl)C(=O)/C=C/C3=CC=C(C=C3)Br
• PubChem CID: 73169083
• Peso molecular: 419.7

Objetivos asociados (humanos)

GPR183 Tchem G-protein coupled receptor 183 (2 Activities)

Discover Target: GPR183

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)