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· · COA & SDS Disponible para cada producto · Same-day shipping on in-stock items MS 436 - Moligand™, ≥95% , Inhibitor of bromodomain containing 4, CAS No.1395084-25-9, Inhibitor of bromodomain containing 4
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95% Synonyms
(E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide | MS436 | 4-[(2Z)-2-(2-amino-5-methyl-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-N-pyridin-2-ylbenzenesulfonamide | MS-436 | 4-[(1E)-2-(2-Amino-4-hydroxy-5-methylpheny
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™, ≥95% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general Product introduction
Ms436 is a bromodomain inhibitor that effectively acts on Brd4 brd1 with a Ki of 30-50 nm, 10 times higher than that of BRD2.
Specifications Sinónimos
(E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide | MS436 | 4-[(2Z)-2-(2-amino-5-methyl-4-oxocyclohexa-2, 5-dien-1-ylidene)hydrazinyl]-N-pyridin-2-ylbenzenesulfonamide | MS-436 | 4-[(1E)-2-(2-Amino-4-hydroxy-5-methylpheny
Especificaciones y pureza
Moligand™, ≥95%
Mecanismos bioquímicos y fisiológicos
Potent and selective BRD4 bromodomain inhibitor (Ki= 30 - 50 nM for the first bromodomain (BRD4(1)). Exhibits 10-fold selectivity for BRD4(1) over BRD4(2). Blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Mecanismo de acción
Inhibitor of bromodomain containing 4
Nombres e identificadores Pubchem Sid 488202974 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488202974 Sonrisas canónicas CC1=CC(=C(C=C1O)N)N=NC2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=N3 IUPAC Name 4-[(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-N-pyridin-2-ylbenzenesulfonamide InChIKey DZTGIRNXWSZBIM-UHFFFAOYSA-N INCHI 1S/C18H17N5O3S/c1-12-10-16(15(19)11-17(12)24)22-21-13-5-7-14(8-6-13)27(25,26)23-18-4-2-3-9-20-18/h2-11,24H,19H2,1H3,(H,20,23) Isómeros SMILES CC1=CC(=C(C=C1O)N)N=NC2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=N3 Peso molecular 383.42 Reaxy-Rn 32452371 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32452371&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Clase Azobenzenes Subclass Not available Intermediate Tree Nodes Not available Direct Parent Azobenzenes Alternative Parents Benzenesulfonamides Benzenesulfonyl compounds m-Aminophenols Ortho cresols Aminotoluenes Aniline and substituted anilines 1-hydroxy-2-unsubstituted benzenoids Pyridines and derivatives Organosulfonamides Imidolactams Aminosulfonyl compounds Heteroaromatic compounds Azo compounds Propargyl-type 1,3-dipolar organic compounds Azacyclic compounds Organic oxides Organooxygen compounds Primary amines Hydrocarbon derivatives Molecular Framework Aromatic heteromonocyclic compounds Substituents Azobenzene - Benzenesulfonamide - Benzenesulfonyl group - Aminophenol - M-aminophenol - O-cresol - Aniline or substituted anilines - Aminotoluene - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Toluene - Imidolactam - Monocyclic benzene moiety - Pyridine - Benzenoid - Organosulfonic acid amide - Heteroaromatic compound - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Sulfonyl - Aminosulfonyl compound - Azo compound - Azacycle - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Primary amine - Organic nitrogen compound - Organic oxygen compound - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Amine - Hydrocarbon derivative - Organic oxide - Aromatic heteromonocyclic compound Descripción This compound belongs to the class of organic compounds known as azobenzenes. These are organonitrogen aromatic compounds that contain a central azo group, where each nitrogen atom is conjugated to a benzene ring. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Solubilidad Solvent:DMSO, Max Conc. mg/mL: 38.31, Max Conc. mM: 100 Peso molecular 383.400 g/mol XLogP3 2.800 Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 8 Rotatable Bond Count 5 Exact Mass 383.105 Da Monoisotopic Mass 383.105 Da Topological Polar Surface Area 138.000 Ų Heavy Atom Count 27 Formal Charge 0 Complexity 601.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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