In Vitro:MS117 (Compound 4) inhibits the PRMT6 methyltransferase activity in a time-dependent manner. MS117 (Compound 4) shows moderate selectivity (6-fold) for PRMT6 over PRMT1 (IC 50 = 0.1 ± 0.025 µM) and PRMT8 (IC 50 = 0.11 ± 0.01 µM). MCE has not ind
Biological Activity:MS117 is a first-in-class and cell-active irreversible protein arginine methyltransferase 6 (PRMT6) covalent inhibitor, with an IC 50 of 18 nM.
Specifications
Especificaciones y pureza
10mM in DMSO
Condiciones de almacenamiento de almacenamiento
Store at -80°C
Enviado en
Dry ice packs + Cold packs
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Tipo de acción
INHIBITOR
Nombres e identificadores
Peso molecular
298.38
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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