MY33-3 - ≥98% , CAS No.2204280-41-9

CAS: 2204280-41-9 Cat. No.: M651218 Peso molecular: 397.40

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Descripción general

MY33-3 is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ , with an IC 50 of ~0.1 μM. MY33-3 also inhibits PTP-1B ( IC 50 ~0.7 μM). MY33-3 can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction

In Vitro

MY33-3 (1 μM; pretreated for 5 min) blocks Ethanol-induced activation of TrkA and ALK in SH-SY5Y cells. MY33-3 (0.1-10 μM; 24 h) limits LPS-induced nitrites production and iNos increases in BV2 microglial cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: SH-SY5Y cells Concentration: 1 μM Incubation Time: Pretreated for 5 min and co-treated for 15 min Result: Decreased the Ethanol-induced activation of TrkA and ALK. None of the treatments significantly changed total TrkA or total ALK protein levels.

In Vivo

MY33-3 (60 mg/kg; p.o. on days 3 and 4) reduces ethanol consumption when comparing day 2 with day 3. MY33-3 reduces preference for the ethanol solution on day 3 . MY33-3 (i.p.) reverses the Sevoflurane-induced decrease in the discrimination index and impaired motor learning ability. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male C57BL/6J mice (8-10 weeks of age) are received two-bottle drinking in the dark (DID) procedure using 20% ethanol Dosage: 60 mg/kg Administration: P.o. 1 hour before the drinking session in the DID test on days 3 and 4 Result: Reduced ethanol consumption when comparing day 2 with day 3. Showed a reduced preference for the ethanol solution. Not affected total fluid consumption.

Form:Solid

IC50& Target:IC50: 0.1 μM (RPTPβ/ζ), 0.7 μM (PTP-1B)

Specifications

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

MY33-3 is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ , with an IC 50 of ~0.1 μM. MY33-3 also inhibits PTP-1B ( IC 50 ~0.7 μM). MY33-3 can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammati

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C, Desiccated

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

• Peso molecular: 397.40