N-(1,3-Dimethylbutyl)-N'-phenyl-1,4-phenylenediamine(6PPD) - ≥98%(GC) , CAS No.793-24-8

CAS: 793-24-8 Cat. No.: N137371 Peso molecular: 268.4 Beilstein Registry Number: 13(4)115 Número EC: 212-344-0
Disponible para pedir
GRADE & PURITY ≥98%(GC)
Synonyms
(4-anilino-phenyl)-(1,3-dimethyl-butyl)-amine | DBDA | MFCD00072248 | Ozonone 6C | Diafen FDMB | DTXSID9025114 | Dusantox 6PPD | BRN 2215491 | GG-0240 | UOP 562 | N-(1,3-dimethylbutyl)-N'-phenylbenzene-1,4-diamine | Flexzone 7F | UNII-HJD0U67PS1 | N-(4-Me
Storage
Protected from light,Room temperature,Desiccated,Cool
Shipped In
Normal
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
5g
N137371-5g
2
9,90US$
25g
N137371-25g
≥10
10,90US$
100g
N137371-100g
3

14,90US$

22,90US$
Guardar 8,00 US$ (34.93%)
500g
N137371-500g
1
99,90US$
Enter a quantity for the sizes you want to add.
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Why this grade

≥98%(GC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Protected from light,Room temperature,Desiccated,Cool Ships Normal Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 37 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

6-PPD (Antioxidant 4020) is an antioxidant that is the most commonly used additive in rubber and enters the environment through large emissions of tire wear particles. 6-PPD can induce neurodegeneration in Caenorhabditis elegans.

Specifications

Sinónimos
(4-anilino-phenyl)-(1, 3-dimethyl-butyl)-amine | DBDA | MFCD00072248 | Ozonone 6C | Diafen FDMB | DTXSID9025114 | Dusantox 6PPD | BRN 2215491 | GG-0240 | UOP 562 | N-(1, 3-dimethylbutyl)-N'-phenylbenzene-1, 4-diamine | Flexzone 7F | UNII-HJD0U67PS1 | N-(4-Me
Especificaciones y pureza
≥98%(GC)
Condiciones de almacenamiento de almacenamiento
Protected from light, Room temperature, Desiccated, Cool
Enviado en
Normal
Tipo de acción
INHIBITOR
Pureza
≥98%(GC)
Nombres e identificadores
Pubchem Sid488181793
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488181793
Sonrisas canónicasCC(C)CC(C)NC1=CC=C(C=C1)NC2=CC=CC=C2
IUPAC Name4-N-(4-methylpentan-2-yl)-1-N-phenylbenzene-1,4-diamine
InChIKeyZZMVLMVFYMGSMY-UHFFFAOYSA-N
INCHI1S/C18H24N2/c1-14(2)13-15(3)19-17-9-11-18(12-10-17)20-16-7-5-4-6-8-16/h4-12,14-15,19-20H,13H2,1-3H3
Isómeros SMILES CC(C)CC(C)NC1=CC=C(C=C1)NC2=CC=CC=C2
RTECS ST0900000
Número ONU 3077
Grupo de embalaje III
Peso molecular 268.4
Beilstein 13(4)115
Reaxy-Rn 2215491
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2215491&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic nitrogen compounds
ClaseOrganonitrogen compounds
SubclassAmines
Intermediate Tree Nodes Aralkylamines
Direct ParentPhenylalkylamines
Alternative Parents Aniline and substituted anilines  Secondary alkylarylamines  Organopnictogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Phenylalkylamine - Aniline or substituted anilines - Secondary aliphatic/aromatic amine - Benzenoid - Monocyclic benzene moiety - Secondary amine - Organopnictogen compound - Hydrocarbon derivative - Aromatic homomonocyclic compound
DescripciónThis compound belongs to the class of organic compounds known as phenylalkylamines. These are organic amines where the amine group is secondary and linked on one end to a phenyl group and on the other end, to an alkyl group.
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RXRA Tclin Retinoid X receptor alpha (3637 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX12 Tchem Arachidonate 12-lipoxygenase (3262 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR1H4 Tclin Bile acid receptor FXR (6228 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lymphoblastoid cell (5959 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Objetivos asociados (no humanos)
Ppard Peroxisome proliferator-activated receptor delta (358 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
lef Anthrax lethal factor (7585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

21 results found

Lot NumberCertificate TypeFechaArticulo
D2621406Certificate of AnalysisMar 25, 2026 N137371
D2621405Certificate of AnalysisMar 25, 2026 N137371
D2621388Certificate of AnalysisMar 25, 2026 N137371
D2621387Certificate of AnalysisMar 25, 2026 N137371
D2621386Certificate of AnalysisMar 25, 2026 N137371
D2615595Certificate of AnalysisMar 06, 2026 N137371
G1626045Certificate of AnalysisSep 16, 2025 N137371
J2318790Certificate of AnalysisAug 07, 2025 N137371
D2412217Certificate of AnalysisMar 13, 2024 N137371
D2412213Certificate of AnalysisMar 13, 2024 N137371
D2319219Certificate of AnalysisMar 15, 2023 N137371
D2319215Certificate of AnalysisMar 15, 2023 N137371
D2319214Certificate of AnalysisMar 15, 2023 N137371
D2319213Certificate of AnalysisMar 15, 2023 N137371
D2319212Certificate of AnalysisMar 15, 2023 N137371
E2522054Certificate of AnalysisMar 15, 2023 N137371
F2412077Certificate of AnalysisMar 15, 2023 N137371
D2319211Certificate of AnalysisMar 15, 2023 N137371
G2507130Certificate of AnalysisMar 15, 2023 N137371
I2414022Certificate of AnalysisMar 15, 2023 N137371
B2521046Certificate of AnalysisMar 15, 2023 N137371

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Propiedades químicas y físicas
SolubilidadSoluble in Methanol
SensibilidadLight sensitive;Moisture sensitive
Punto de ebullición (°C)165 °C/1 mmHg
Punto de fusión (°C)51 °C
Peso molecular268.400 g/mol
XLogP35.600
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Exact Mass268.194 Da
Monoisotopic Mass268.194 Da
Topological Polar Surface Area24.100 Ų
Heavy Atom Count20
Formal Charge0
Complexity250.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Preguntas frecuentes y artículos
Citations of This Product
Referencias
1. Liya Fang, Chanlin Fang, Shanshan Di, Yundong Yu, Caihong Wang, Xinquan Wang, Yuanxiang Jin.  (2023)  Oral exposure to tire rubber-derived contaminant 6PPD and 6PPD-quinone induce hepatotoxicity in mice.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:36716866] [10.1016/j.scitotenv.2023.161836]
2. Jiawen Ji, Changsheng Li, Bingjie Zhang, Wenjuan Wu, Jianli Wang, Jianhui Zhu, Desheng Liu, Rumin Gao, Yongqiang Ma, Sen Pang, Xuefeng Li.  (2022)  Exploration of emerging environmental pollutants 6PPD and 6PPDQ in honey and fish samples.  FOOD CHEMISTRY,      [PMID:35839723] [10.1016/j.foodchem.2022.133640]
3. Jiawen Ji, Jinze Huang, Niannian Cao, Xianghong Hao, Yanhua Wu, Yongqiang Ma, Dong An, Sen Pang, Xuefeng Li.  (2022)  Multiview behavior and neurotransmitter analysis of zebrafish dyskinesia induced by 6PPD and its metabolites.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:35588826] [10.1016/j.scitotenv.2022.156013]
4. Mengzhu Lv, Xiaoyu Mao, Zheng Lu, Yanzhu Yang, Jiangtao Huang, Yuqin Cheng, Chuan Ye, Zhixu He, Liping Shu, Dashuang Mo.  (2024)  6PPD induces cerebrovascular defects by triggering oxidative stress and ferroptosis in zebrafish.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:39689467] [10.1016/j.scitotenv.2024.178004]
5. Haiming Wang, Zhuanxi Luo, Anteng Dai, Xu Liao, Changzhou Yan, Ruilian Yu, Shufeng Zhou, Baoshan Xing.  (2024)  Ascertaining appropriate measuring methods to determine tire wear particle pollution on driving school grounds in China.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:38309163] [10.1016/j.jhazmat.2024.133657]
6. Haixiang Jia, Xiaohe Miao, Zhiyi Zhang.  (2024)  Building Chemical Interface Layers in Functionalized Graphene Oxide/Rubber Composites to Achieve Enhanced Mechanical Properties and Thermal Control Capability of Tires.  Polymers,  16  (16): (2234).  [PMID:39204454] [10.3390/polym16162234]
7. Yang Liu, Liu Kexin, Shi Lina, Chen Ming, Liu Junyan, Dai Shiniu, Xi Yilong, Wen Xinli.  (2024)  Chronic toxicity and intergenerational effects of N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD) exposure alone and in combination with Zn2+ on Daphnia magna (Cladocera).  ECOTOXICOLOGY,      [PMID:39612103] [10.1007/s10646-024-02836-x]
8. Zhe Wang, Mingjun Zhu, Yao Hu, Jiaxi Liu, Xiaoyu Ma, Hong Zhou.  (2025)  Comparative effects of 6PPD and 6PPD-Quinone at environmentally relevant concentrations on hepatotoxicity, glucolipid metabolism and ferroptotic response in adult zebrafish.  ENVIRONMENTAL RESEARCH,      [PMID:40086579] [10.1016/j.envres.2025.121386]
9. Zehua Song, Xiaomei Yu, Minghua Zhu, Zimeng Wu, Zhiqiang Fu, Jingwen Chen.  (2024)  Distinct Species-Specific and Toxigenic Metabolic Profiles for 6PPD and 6PPD Quinone by P450 Enzymes: Insights from In Vitro and In Silico Studies.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:39120070] [10.1021/acs.est.4c03361]
10. Chunyu Liu, Xingchen Zhao, Liqiong Guo, Qilin Yu, Weifei Zhang, Zijuan Peng, Yan Gao, Xiaoyun Gong, Penghui Li, Hui Jiao, Tao Zhou, Qinghe Zhang, Shanjun Song, Guibin Jiang.  (2024)  Emerging N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and 6PPD quinone in paired human plasma and urine from Tianjin, China: Preliminary assessment with demographic factors.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:38901252] [10.1016/j.jhazmat.2024.134818]
11. Jiawei Yang, Feifei Wang, Chaobo Liang, Shaofeng Zhou, Jin Huang, Guizhe Zhao, Yaqing Liu.  (2024)  Enhanced abrasion resistance of NR/BR/TBIR composites through the synergistic reinforcement of carbon black and graphene oxide: Structural influence and mechanistic insights.  POLYMER COMPOSITES,      [PMID:] [10.1002/pc.29093]
12. Jiawen Ji, Siyue Zhu, Xinping Hu, Jianhui Zhu, Sen Pang, Yongqiang Ma, Xuefeng Li.  (2025)  Enhanced residual risk of abamectin induced by 6PPD: in water, soil, and vegetables.  Environmental Science-Processes & Impacts,      [PMID:40099488] [10.1039/D5EM00053J]
13. Chenyang Rao, Yanxia Zuo, Dongfang Xiang, Bo Xian, Fuhao Chu, Fang Fang, Xiaowei Xiang, Wei Tang, Shaopan Bao, Tao Fang.  (2025)  Exploring the fate of 6PPD in zebrafish (Danio rerio): Understanding toxicokinetics, biotransformation mechanisms, and metabolomic profiling at environmentally relevant levels.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:40007367] [10.1016/j.jhazmat.2025.137687]
14. Xiaohe Miao, Xiaoyuan Duan, Huatao Cheng, Haoyu Duan, Zhiyi Zhang, Yaqing Liu, Shuaishuai Cheng.  (2024)  Green and energy-saving tread rubber by constructing chemical cross-linking interface between graphene oxide and natural rubber.  COMPOSITES COMMUNICATIONS,      [PMID:] [10.1016/j.coco.2024.102067]
15. Qu-Nan Wang, Chunzhi Wang, Yán Wāng.  (2025)  Inhalation exposure to tire rubber particle-sourced pollutant 6PPD-quinone involving basolateral amygdala impairment in male ICR mice.  Journal of Advanced Research,      [PMID:40118340] [10.1016/j.jare.2025.03.033]
16. Chen Wang, Meichen Sun, Minghui He, Siyu Zhao, Meinuo Lv, Xiaotian Xu, Chunbei Ye, Linjing Li, Limin Su, Yuanhui Zhao.  (2024)  Photolysis of p-phenylenediamine rubber antioxidants in aqueous environment: Kinetics, pathways and their photo-induced toxicity.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:39236532] [10.1016/j.jhazmat.2024.135718]
17. Yuexing Zhao, Weitao Liu, Jinzheng Liu, Ruiying Shi, Aurang Zeb, Xiang Li, Yichen Ge.  (2024)  Phytotoxicity of 6PPD and its uptake by Myriophyllum verticillatum: Oxidative stress and metabolic processes.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:39477116] [10.1016/j.scitotenv.2024.177248]
18. Xiangxu Li, Lei Wu, Qingxiang Lai, Yifan Xu, He Wang, Chuansheng Wang, Huiguang Bian.  (2024)  Preparation of aqueous silane-graphene oxide co-modified cellulose fibers/natural rubber composites via flash extrusion dispersion process.  POLYMER ENGINEERING AND SCIENCE,      [PMID:] [10.1002/pen.26854]
19. Shike Zhang, Xinyi Su, Jiada Zhang, Tingting He, Lei Tang, Zepei Zhao, Linying Cao.  (2024)  Tire rubber derivative 6PPD and 6PPD-Q induce lipid accumulation in hepatocytes through ERRγ pathway.  Journal of Environmental Sciences,      [PMID:] [10.1016/j.jes.2024.09.023]
20. Fang Chanlin, Di Shanshan, Wang Caihong, Hu Qinglian, Jin Yuanxiang.  (2024)  Tire rubber-derived contaminant 6PPD had the potential to induce metabolism disorder in early developmental stage of zebrafish.  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,      [PMID:39490946] [10.1016/j.cbpc.2024.110062]
21. Chenyang Rao, Fuhao Chu, Fang Fang, Dongfang Xiang, Bo Xian, Xiaying Liu, Shaopan Bao, Tao Fang.  (2024)  Toxic effects and comparison of common amino antioxidants (AAOs) in the environment on zebrafish: A comprehensive analysis based on cells, embryos, and adult fish.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:38485016] [10.1016/j.scitotenv.2024.171678]
22. Chanlin Fang, Yundong Yu, Shanshan Di, Xinquan Wang, Yuanxiang Jin.  (2024)  Untargeted metabolomic analysis reveals a time-course hepatic metabolism disorder induced by short-term 6PPD exposure in rats.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:39437917] [10.1016/j.scitotenv.2024.177071]
23. Rongyao Tao, Rizhen He, Yaqing Liu, Shuaishuai Cheng, Dong An, Guizhe Zhao.  (2025)  Charge optimization for high-performance graphene oxide/natural rubber composites to study the filler-rubber interfacial interaction in different states of rubber.  CARBON,      [PMID:] [10.1016/j.carbon.2025.120628]
24. Liya Fang, Jinhua Xu, Chanlin Fang, Yuanxiang Jin.  (2025)  Oral exposure to tire rubber-derived contaminant 6PPD and 6PPD-quinone induces intestinal toxicity in mice.  TOXICOLOGY,      [PMID:40976059] [10.1016/j.tox.2025.154285]
25. Yuexing Zhao, Weitao Liu, Jianfeng Feng, Ning Gao, Jinzheng Liu, Ruiying Shi, Aurang Zeb, Jianling Wang, Qi Wang, Chuan Yin, Xinwei Shi, Xiang Li, Yichen Ge.  (2025)  Polystyrene microplastics alter the toxicity of 6PPD to zebrafish (Danio rerio) larvae.  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,      [PMID:40957530] [10.1016/j.cbpc.2025.110356]
26. Jing Zhang, Qiang Ma, Honghui Wang, Bin Chen, Yan Li, Yingmin Liao.  (2025)  Molecular insights into the transport and toxicity of 6-PPD: Interactions with human serum albumin and alpha-glucosidase.  BIOPHYSICAL CHEMISTRY,      [PMID:41014659] [10.1016/j.bpc.2025.107529]
27. Xiaoyu Mao, Dashuang Mo, Yuqin Cheng, Mengzhu Lv.  (2025)  6PPD impairs immune responses and fin regeneration in zebrafish.  TOXICOLOGY LETTERS,      [PMID:40188975] [10.1016/j.toxlet.2025.04.001]
28. Jiaqi Shi, Yan Li, Qi Wei, Xin Zhu, Shaohua Cao, Wenyi Xie, Yang Guo, Jing Wei, Zekai Li, Tao Long.  (2025)  Interaction between 6PPD/6PPD-Q and natural Fe-Mn nodules: Performance and mechanism of adsorption and oxidative transformation.  ENVIRONMENT INTERNATIONAL,      [PMID:40220692] [10.1016/j.envint.2025.109438]
29. Wang Yiyu, Su Huijun, Liu Ning, Yang Naiwang, Gao Pingqiang.  (2025)  Distribution of synthetic antioxidants in outdoor and educational indoor dusts and assessment of human exposure.  ENVIRONMENTAL GEOCHEMISTRY AND HEALTH,  47  (5): (1-14).  [PMID:40281297] [10.1007/s10653-025-02496-8]
30. Chao Wang, Junhao Lin, Jiewei Deng, Xinyan Li, Junqiu Zhai, Yunyun Yang, Tiangang Luan.  (2025)  6PPD and 6PPDQ exposure promote the proliferation and migration of non-small cell lung cancer cells through PTEN dysfunction and ARG2-mediated metabolic reprogramming.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:40602111] [10.1016/j.jhazmat.2025.139088]
31. Chenyang Rao, Yanxia Zuo, Tianyu Gao, Dongfang Xiang, Fuhao Chu, Xiaowei Xiang, Xingkang Deng, Wei Tang, Shaopan Bao, Tao Fang.  (2025)  Integrative multi-omics and molecular modeling reveal mechanisms of 6PPD-induced hepatic oxidative stress and energy metabolism disruption in zebrafish.  JOURNAL OF ENVIRONMENTAL MANAGEMENT,      [PMID:41082844] [10.1016/j.jenvman.2025.127611]
32. Zitao Yu, Xiyan Dong, Danyang Cao, Zhongfan Luo, Yongguang Yu, Huaze Sun, Zhenyuan Xiao, Jiahua Zhu, Xiaohua Lu, Liwen Mu.  (2025)  Mechanistic Insight into Lignin as a Green Rubber Additive: Correlation Analysis of Structural Parameters.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,      [PMID:] [10.1021/acs.iecr.5c02452]
33. Liu Yang, Xue Tang, Yongsheng Zhou, Shiniu Dai, Kexin Liu, Lina Shi, Xinli Wen.  (2025)  Comparative study on the reproduction toxicity of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) to Daphnia magna based on a 21-day short-term exposure and whole-life-stage exposure and the underlying toxic mechanisms.  AQUATIC TOXICOLOGY,      [PMID:41232398] [10.1016/j.aquatox.2025.107640]
34. Yuanhua Wang, Jie Ren, Siling Zhang, Hao Xu.  (2025)  Sex-specific effects of 6PPD on adult zebrafish: male-selective feeding inhibition, nutrient malabsorption, intestinal epithelial damage, and absence of reproductive toxicity.  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,      [PMID:41290095] [10.1016/j.cbpc.2025.110403]
35. Liya Fang, Chanlin Fang, Shanshan Di, Xinquan Wang, Yuanxiang Jin.  (2026)  Rubber-Derived Contaminants N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine and N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone Alter Intergenerational Cholesterol Metabolism in F1 Offspring of Exposed Mice.  TOXICOLOGY LETTERS,      [PMID:41513114] [10.1016/j.toxlet.2026.111826]
36. Mengzhu Lv, Zheng Lu, Xiaoyu Mao, Jiangtao Huang, Qianqian Zheng, Dashuang Mo, Liping Shu.  (2026)  6PPD impairs liver growth through inflammatory pathways: Insights from zebrafish and human cell models.  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,      [PMID:41525898] [10.1016/j.cbpc.2026.110454]
37. Jingqi Ruan, Teng Zhang, Peizeng Yang, Xinping Yang, Bin Gao, Junhe Lu, Deyang Kong.  (2026)  Enhanced photodegradation of 6PPD and formation of 6PPD-quinone in ice.  WATER RESEARCH,      [PMID:] [10.1016/j.watres.2026.125673]
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