≥97%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
NAc-Asp-Glu-Val-Asp-pNA;Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) (Km=9.7μM) and related cysteine proteases. It is also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10. The sequence is based on PARP (poly(ADPribose) polymerase) cleavage site Asp216 for caspase-3. Cleavage is monitored colorimetrically at 405nm.
A colorimetric substrate for caspase-3 (CPP32) and related cysteine proteases
| Sonrisas canónicas | CC(C)C(C(=O)NC(CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C |
|---|---|
| IUPAC Name | (4S)-4-[[(2S)-2-acetamido-3-carboxypropanoyl]amino]-5-[[(2S)-1-[[(2S)-3-carboxy-1-(4-nitroanilino)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid |
| InChIKey | GGXRLUDNGFFUKI-ORGXJRBJSA-N |
| INCHI | 1S/C26H34N6O13/c1-12(2)22(26(43)30-18(11-21(38)39)24(41)28-14-4-6-15(7-5-14)32(44)45)31-23(40)16(8-9-19(34)35)29-25(42)17(10-20(36)37)27-13(3)33/h4-7,12,16-18,22H,8-11H2,1-3H3,(H,27,33)(H,28,41)(H,29,42)(H,30,43)(H,31,40)(H,34,35)(H,36,37)(H,38,39)/t16-,17-,18-,22-/m0/s1 |
| Isómeros SMILES | CC(C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)C |
| Peso molecular | 638.58 |
| Reaxy-Rn | 29648908 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29648908&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Clase | Carboxylic acids and derivatives |
| Subclass | Amino acids, peptides, and analogues |
| Intermediate Tree Nodes | Peptides |
| Direct Parent | Oligopeptides |
| Alternative Parents | Glutamic acid and derivatives Aspartic acid and derivatives Valine and derivatives N-acyl-alpha amino acids and derivatives Alpha amino acid amides Tricarboxylic acids and derivatives Anilides Nitrobenzenes Nitroaromatic compounds N-arylamides N-acyl amines Acetamides Secondary carboxylic acid amides Propargyl-type 1,3-dipolar organic compounds Organic oxoazanium compounds Carboxylic acids Carbonyl compounds Organic zwitterions Organic salts Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Alpha-oligopeptide - Glutamic acid or derivatives - Aspartic acid or derivatives - N-acyl-alpha amino acid or derivatives - Valine or derivatives - Alpha-amino acid amide - Alpha-amino acid or derivatives - N-substituted-alpha-amino acid - Anilide - Nitrobenzene - Tricarboxylic acid or derivatives - Nitroaromatic compound - N-arylamide - Benzenoid - Monocyclic benzene moiety - Fatty amide - Fatty acyl - N-acyl-amine - Acetamide - Carboxamide group - Organic nitro compound - C-nitro compound - Secondary carboxylic acid amide - Organic oxoazanium - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Carboxylic acid - Allyl-type 1,3-dipolar organic compound - Organonitrogen compound - Organic oxide - Organic salt - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organooxygen compound - Organic zwitterion - Aromatic homomonocyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 E2315851 | Certificate of Analysis | Feb 07, 2025 | N133165 |
| E2315855 | Certificate of Analysis | Feb 07, 2025 | N133165 |
| E2315909 | Certificate of Analysis | Feb 07, 2025 | N133165 |
| L1521036 | Certificate of Analysis | May 12, 2023 | N133165 |
| Solubilidad | Soluble in water (partly), DMSO, buffer, pH 7, and acetonitrile:methanol (1:1) (1 mg/ml). |
|---|---|
| Peso molecular | 638.600 g/mol |
| XLogP3 | -1.400 |
| Hydrogen Bond Donor Count | 8 |
| Hydrogen Bond Acceptor Count | 13 |
| Rotatable Bond Count | 17 |
| Exact Mass | 638.218 Da |
| Monoisotopic Mass | 638.218 Da |
| Topological Polar Surface Area | 303.000 Ų |
| Heavy Atom Count | 45 |
| Formal Charge | 0 |
| Complexity | 1150.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 4 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Jia Li, Yuxin Liu, Huanhuan Yang, Luyun Cai, Wenqian Nong, Weiliang Guan. (2024) The Activation of Endogenous Proteases in Shrimp Muscle Under Water-Free Live Transport. Foods, 13 (21): (3472). [PMID:39517256] [10.3390/foods13213472] |
| 2. Ziyun Miao, Pei Xu, Yurong Wei, Jiahui Tan, Zhenwei Liu, Jie Pan, Lin Shi, Yong Wang, Jie Wang. (2025) Transformative effects of homo-valence ion doping on persistent luminescence nanophosphors for radiotherapy monitoring. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.161412] |
