N,N-Bis(2-hidroxietil)glicina - ≥99% , CAS No.150-25-4

CAS: 150-25-4 Cat. No.: B110905 Peso molecular: 163.17 Beilstein Registry Number: 1769362 Número EC: 205-755-1

GRADE & PURITY ≥99%

Synonyms

BICINE | BBL011024 | BICINE, BioXtra, >=99% (titration) | Diethylolglycine | Glycine, N,N-bis(2-hydroxyethyl)- | N,N-(2-Dihydroxyethyl)glycine | N,N-Bis-(2-hydroxyethyl)aminoacetic acid | N,N-Bis(2-hydroxyethyl)aminoacetic acid | MFCD00004295 | A809025 |

Storage

Temperatura ambiente

Shipped In

Normal

Descripción general

La bicina es un tampón aminoácido zwitteriónico, activo en el intervalo de pH 7,6-9,0 (pKa de 8,26 a 25°C). Tampón recomendado para trabajos bioquímicos a baja temperatura. La bicina se utiliza para la preparación de una solución de sustrato estable para la determinación de guanasa sérica. Se ha publicado el uso de bicina en un método de cromatografía de intercambio iónico de capa fina para la resolución de proteínas. La bicina se ha utilizado en la cristalización de péptidos y proteínas. En un estudio cinético de un complejo cuaternario análogo del estado de transición de la creatina quinasa se utilizó bicina en el tampón de reacción. Se ha descrito un sistema tampón multifásico para SDS-PAGE de proteínas y péptidos que incorpora bicina.
Tampón recomendado para trabajos bioquímicos a baja temperatura.Utilizado en la preparación de una solución de sustrato estable para la determinación de guanasa sérica.Espaciador en el fraccionamiento de proteínas plasmáticas con Sephadex? por isotacoforesis.

Specifications

Sinónimos

BICINE | BBL011024 | BICINE, BioXtra, >=99% (titration) | Diethylolglycine | Glycine, N, N-bis(2-hydroxyethyl)- | N, N-(2-Dihydroxyethyl)glycine | N, N-Bis-(2-hydroxyethyl)aminoacetic acid | N, N-Bis(2-hydroxyethyl)aminoacetic acid | MFCD00004295 | A809025 |

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

Tampón de uso general ampliamente utilizado en la investigación biológica. Rango de pH de trabajo en solución acuosa: 7.6-9.0. Utilizado en cristalización de proteínas, cromatografía de intercambio iónico y SDS-PAGE.

Condiciones de almacenamiento de almacenamiento

Temperatura ambiente

Enviado en

Normal

Pureza

≥99%

Nombres e identificadores

• Pubchem Sid: 504751728
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504751728
• Sonrisas canónicas: C(CO)N(CCO)CC(=O)O
• IUPAC Name: 2-[bis(2-hydroxyethyl)amino]acetic acid
• InChIKey: FSVCELGFZIQNCK-UHFFFAOYSA-N
• INCHI: 1S/C6H13NO4/c8-3-1-7(2-4-9)5-6(10)11/h8-9H,1-5H2,(H,10,11)
• Isómeros SMILES: C(CO)N(CCO)CC(=O)O
• WGK Alemania: 1
• RTECS: MB9700000
• Peso molecular: 163.17
• Beilstein: 1769362
• Reaxy-Rn: 1769362
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1769362&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Alpha amino acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Alpha amino acids
• Alternative Parents: Trialkylamines Amino acids 1,2-aminoalcohols Monocarboxylic acids and derivatives Carboxylic acids Primary alcohols Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Alpha-amino acid - 1,2-aminoalcohol - Amino acid - Tertiary aliphatic amine - Tertiary amine - Alkanolamine - Carboxylic acid - Monocarboxylic acid or derivatives - Organic nitrogen compound - Primary alcohol - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Carbonyl group - Amine - Organopnictogen compound - Organic oxygen compound - Alcohol - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).
• External Descriptors: bicine

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: Solvent:water, Max Conc. mg/mL: 326.34, Max Conc. mM: 2000
• Punto de fusión (°C): 190-192°C
• Peso molecular: 163.170 g/mol
• XLogP3: -3.800
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 163.084 Da
• Monoisotopic Mass: 163.084 Da
• Topological Polar Surface Area: 81.000 Ų
• Heavy Atom Count: 11
• Formal Charge: 0
• Complexity: 111.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Sun Yu-Long, Ge Bing-Qiang, Li Mi-Zhuan, Wang Lei, Chen Zhong-Xiu.  (2023)  The effect of macromolecular crowding degree on the self-assembly of fatty acid and lipid hydrolysis.  npj Science of Food,  7  (1): (1-8).  [PMID:37495579] [10.1038/s41538-023-00213-2]

2. Lu Xiaolei, Jia Jian, Ye Zhengmao, Du Peng, Chen Heng, Wu Jiaming, Cheng Xin.  (2022)  The influence of bicine on the hydration and properties of Portland cement.  JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY,  147  (23): (13125-13134).  [PMID:] [10.1007/s10973-022-11702-z]

3. Wen Guo-Yu, Zhou Xing-Long, Tian Xiao-Yu, Xie Rui, Ju Xiao-Jie, Liu Zhuang, Faraj Yousef, Wang Wei, Chu Liang-Yin.  (2022)  Smart hydrogels with wide visible color tunability.  NPG Asia Materials,  14  (1): (1-10).  [PMID:] [10.1038/s41427-022-00379-3]

4. Liu Jiansheng, Li Jiajia, Zhang Shu, Ding Mengbin, Yu Ningyue, Li Jingchao, Wang Xiuhui, Li Zhaohui.  (2022)  Antibody-conjugated gold nanoparticles as nanotransducers for second near-infrared photo-stimulation of neurons in rats.  Nano Convergence,  9  (1): (1-13).  [PMID:35312875] [10.1186/s40580-022-00304-y]

5. Ping Sun, Jing Wu, Shenghong Yang, Hongli Li, Lei Zhao, Yuanhang Wang, Xiayan Wang, Qiaosheng Pu.  (2021)  Robust and easy-to-use microchip electrophoresis within sub-millimeter channels for fast and highly efficient separation.  TALANTA,      [PMID:34517615] [10.1016/j.talanta.2021.122747]

6. Yongfeng Mu, Han Feng, Shengdao Wang, Shuling Zhang, Jiashuang Luan, Mei Zhang, Zhenxiang Yu, Guibin Wang.  (2020)  Combined strategy of blending and surface modification as an effective route to prepare antifouling ultrafiltration membranes.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:33450453] [10.1016/j.jcis.2020.12.114]

7. Xi Zhang, Chang Liu, Jing Yang, Xiao-Jun Huang, Zhi-Kang Xu.  (2020)  Wettability Switchable Membranes for Separating Both Oil-in-water and water-in-oil emulsions.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2020.118976]

8. Xi Zhang, Chang Liu, Jing Yang, Cheng-Ye Zhu, Lin Zhang, Zhi-Kang Xu.  (2019)  Nanofiltration membranes with hydrophobic microfiltration substrates for robust structure stability and high water permeation flux.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2019.117444]

9. Zhao Jie.  (2019)  Inspired by Grape Seed and Wine: Tannic Acid as a Modified Coating for Fabricating Highly Flexible, Transparent and Conductive Film.  CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,  35  (5): (945-950).  [PMID:] [10.1007/s40242-019-8315-2]

10. Bu Yiming, Zhang Shiyu, Cai Yajun, Yang Yingying, Ma Sitian, Huang Jingjing, Yang Hongjun, Ye Dezhan, Zhou Yingshan, Xu Weilin, Gu Shaojin.  (2018)  Fabrication of durable antibacterial and superhydrophobic textiles via in situ synthesis of silver nanoparticle on tannic acid-coated viscose textiles.  CELLULOSE,  26  (3): (2109-2122).  [PMID:] [10.1007/s10570-018-2183-7]

11. Hao Ling, Sen Liu, Hongxia Gao, Zhiwu Liang.  (2018)  Effect of heat-stable salts on absorption/desorption performance of aqueous monoethanolamine (MEA) solution during carbon dioxide capture process.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2018.12.001]

12. Xi Chen, Yi He, Yi Fan, Guangyong Zeng, Liyun Zhang.  (2018)  Nature-inspired polyphenol chemistry to fabricate halloysite nanotubes decorated PVDF membrane for the removal of wastewater.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2018.11.036]

13. Yiming Bu, Jingjing Huang, Shiyu Zhang, Yinghua Wang, Shaojin Gu, Genyang Cao, Hongjun Yang, Dezhan Ye, Yingshan Zhou, Weilin Xu.  (2018)  Robust superhydrophobic surface by nature-inspired polyphenol chemistry for effective oil-water separation.  APPLIED SURFACE SCIENCE,      [PMID:] [10.1016/j.apsusc.2018.01.177]

14. Xi Zhang, Yan Lv, Hao-Cheng Yang, Yong Du, Zhi-Kang Xu.  (2016)  Polyphenol Coating as an Interlayer for Thin-Film Composite Membranes with Enhanced Nanofiltration Performance.  ACS Applied Materials & Interfaces,      [PMID:27933848] [10.1021/acsami.6b10693]

15. Wentong Song, Shengyang Tao, Yongxian Yu, Xuanlu Du, Shuo Wang.  (2016)  Preparing magnetic multicomponent catalysts via a bio-inspired assembly for heterogeneous reactions.  RSC Advances,  6  (74): (69909-69918).  [PMID:] [10.1039/C6RA12088A]

16. Yuchao Wang, Da Shi, Shengyang Tao, Wentong Song, Hongmin Wang, Xinkui Wang, Guangtao Li, Jieshan Qiu, Min Ji.  (2015)  A General, Green Chemistry Approach for Immobilization of Inorganic Catalysts in Monolithic Porous Flow-Reactors.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.5b01541]

17. Xi Zhang, Peng-Fei Ren, Hao-Cheng Yang, Ling-Shu Wan, Zhi-Kang Xu.  (2015)  Co-deposition of tannic acid and diethlyenetriamine for surface hydrophilization of hydrophobic polymer membranes.  APPLIED SURFACE SCIENCE,      [PMID:] [10.1016/j.apsusc.2015.11.015]

18. Jiansheng Liu, Jiajia Li, Yanhui Shi, Anni Zhu, Mengbin Ding, Ningyue Yu, Yongkang Liu, Ping Wang, Jingchao Li, Yu Liu.  (2024)  Second Near-Infrared Activatable Nitric Oxide Releasing Nanoactuators for Photothermal Combinational Modulation of Epileptogenic Focus.  Small Structures,      [PMID:] [10.1002/sstr.202300508]

19. Xinnian Meng, Jingqi Chen, Zeyang Liu, Yongming Tang.  (2025)  pH-Sensitive halloysite nanocontainers encapsulated by silicate-mediated tannic acid networks for the smart epoxy coatings.  Surfaces and Interfaces,      [PMID:] [10.1016/j.surfin.2025.107538]

20. Huanyu Zhou, Xiaolian Jiang, Qing Han, Minghui Qiu, Xiaowei Da, Xianfu Chen, Yiqun Fan.  (2025)  In-situ ion-assisted sol-gel method for homogeneous CeO2 mesopore membrane.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.163665]

21. Zhihao Jin, Yan Yue, Hao Xiong, Xianfu Chen, Minghui Qiu, Yiqun Fan.  (2025)  A novel low-temperature densification method for the construction of YSZ electrolyte membranes derived from nanoparticles.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2025.124373]

22. Tingting Zhang, Mengyi Xu, Yan Zhang, Zhiwen Li, Danqing Song, Jing Pang, Ke Li, Yanxiang Wang.  (2026)  Chemically Engineered L. reuteri Delivering αPD-L1 and Gallium Ions via Metal-Phenolic Networks Potentiate Anti-Tumor Immunity and Ferroptosis.  Advanced Science,      [PMID:] [10.1002/advs.202521638]