N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine - ≥97% , CAS No.16858-02-9

CAS: 16858-02-9 Cat. No.: N159625 Peso molecular: 424.55 Beilstein Registry Number: 4211980 Número EC: 605-520-7

GRADE & PURITY ≥97%

Synonyms

1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)- | HY-100202 | N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine | N,N,N',N'-Tetrakis(2-pyridyl-methyl)ethylenediamine | N1,N1,N2,N2-Tetrakis(pyridin-2-ylmethyl)ethane-1,2-diamine | BRD-K10385824-0

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Sinónimos

1, 2-Ethanediamine, N, N, N', N'-tetrakis(2-pyridinylmethyl)- | HY-100202 | N, N, N', N'-Tetrakis(2-pyridylmethyl)ethylenediamine | N, N, N', N'-Tetrakis(2-pyridyl-methyl)ethylenediamine | N1, N1, N2, N2-Tetrakis(pyridin-2-ylmethyl)ethane-1, 2-diamine | BRD-K10385824-0

Especificaciones y pureza

≥97%

Mecanismos bioquímicos y fisiológicos

N, N, N′, N′-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) elicits pro-apoptotic effect in human acute promyelocytic NB4 cells by inhibiting nitric oxide signalling and Zn2+ signaling.[1] In microglia pretreated with zinc, TPEN inhibits the interleukin 6 s

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥97%

Nombres e identificadores

• Pubchem Sid: 504750905
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504750905
• Sonrisas canónicas: C1=CC=NC(=C1)CN(CCN(CC2=CC=CC=N2)CC3=CC=CC=N3)CC4=CC=CC=N4
• IUPAC Name: N,N,N',N'-tetrakis(pyridin-2-ylmethyl)ethane-1,2-diamine
• InChIKey: CVRXLMUYFMERMJ-UHFFFAOYSA-N
• INCHI: 1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2
• Isómeros SMILES: C1=CC=NC(=C1)CN(CCN(CC2=CC=CC=N2)CC3=CC=CC=N3)CC4=CC=CC=N4
• WGK Alemania: 3
• Peso molecular: 424.55
• Beilstein: 4211980
• Reaxy-Rn: 4211982
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4211982&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Pyridines and derivatives
      • Subclass 2-pyridylmethylamines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Pyridines and derivatives
• Subclass: 2-pyridylmethylamines
• Intermediate Tree Nodes: Not available
• Direct Parent: 2-pyridylmethylamines
• Alternative Parents: Aralkylamines Heteroaromatic compounds Trialkylamines Azacyclic compounds Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: 2-pyridylmethylamine - Aralkylamine - Heteroaromatic compound - Tertiary aliphatic amine - Tertiary amine - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Amine - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as 2-pyridylmethylamines. These are aromatic heterocyclic compounds contaning a pyridine ring which is substituted at the 2-position with a methylamine.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

MOLT-4 (49676 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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SMN1 Tchem Survival motor neuron protein (34246 Activities)

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HSPA5 Tchem 78 kDa glucose-regulated protein (3319 Activities)

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Objetivos asociados (no humanos)

Staphylococcus aureus (210822 Activities)

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Staphylococcus epidermidis (22802 Activities)

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Citrobacter freundii (1864 Activities)

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Enterococcus faecium (13803 Activities)

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Enterococcus faecalis (29875 Activities)

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PC-12 (7051 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

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Impa1 Inositol monophosphatase 1 (16203 Activities)

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Lin28a Protein lin-28 homolog A (33 Activities)

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SARS-CoV-2 (38078 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in Methanol
• Punto de fusión (°C): 112 °C(dec.)
• Peso molecular: 424.500 g/mol
• XLogP3: 2.100
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 11
• Exact Mass: 424.238 Da
• Monoisotopic Mass: 424.238 Da
• Topological Polar Surface Area: 58.000 Ų
• Heavy Atom Count: 32
• Formal Charge: 0
• Complexity: 419.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Yan Liang, Jinjin Wang, Chenlu Xu, Wenshuai Han, Sixuan Wu, Yonghua Wu, Jingge Zhang, Junjie Liu, Zhenzhong Zhang, Jinjin Shi, Kaixiang Zhang.  (2023)  Remodeling Collagen Microenvironment in Liver Using a Biomimetic Nano-Regulator for Reversal of Liver Fibrosis.  Advanced Science,      [PMID:37088730] [10.1002/advs.202300127]

2. Qinyu Luo, Zehua Wu, Yihang Pan, Yan Zhang.  (2025)  Disulfiram inhibits bacterial growth by inducing zinc-dependent reactive oxygen species.  Frontiers in Microbiology,      [PMID:40746315] [10.3389/fmicb.2025.1619416]

3. Cai ZhaoLong, Wang HongRu, Han Fuxin, Wang JingJing, LV Hongli, Gao Xue-jiao, Guo Meng-yao.  (2025)  Zinc Deficiency Induces Hepatic Oxidative Stress, Inflammation, and Programmed Cell Death in Mice.  BIOLOGICAL TRACE ELEMENT RESEARCH,      [PMID:40550979] [10.1007/s12011-025-04715-w]

4. Heng Li, Zhiyue Zhang, Yu Wang, Ting Mou, Jiaqi Tian, Chong Huang, Lu Zhao, Zeyang Ge, Dandan Wang, Chunlin Zong.  (2026)  Multifunctional Fe3O4@ZIF-8 Nanoparticles with Antibiosis and Osteogenesis for Treatment of Jaw Osteomyelitis.  Pharmaceutics,  18  (3):   [PMID:] [10.3390/pharmaceutics18030359]