N-Phenylanthranilic acid（DpC） - AR, ≥95% , Channel blocker of ClC-2, CAS No.91-40-7, Channel blocker of ClC-2

CAS: 91-40-7 Cat. No.: P105693 Peso molecular: 213.23 Beilstein Registry Number: 1456607 Número EC: 202-066-8

GRADE & PURITY AR, ≥95%

Synonyms

AI3-08880 | CCG-204107 | KBioGR_002302 | NCGC00014989-03 | Bio2_000621 | N-Phenyl 2-Aminobenzoic Acid | N-Phenylanthranilic | NSC4273 | NSC-4273 | LP00011 | NSC 215211 | KBioSS_002304 | NCGC00093536-02 | N-PHENYLANTHRANILIC ACID [MI] | 2-(Phenylamino)benz

Storage

Protected from light,Room temperature

Shipped In

Normal

Descripción general

Fenamic acid (N-Phenylanthranilic acid, NPAA) is a chloride channel blocker. Fenamic acid is the basic constituent of non-steroidal anti-inflammatory agents (NSAIA), and derives into mefenamic, tofenacin, flufenac acid and melofenac acid. Fenamic acid also acts as antibacterial and analgesic agent

Specifications

Sinónimos

AI3-08880 | CCG-204107 | KBioGR_002302 | NCGC00014989-03 | Bio2_000621 | N-Phenyl 2-Aminobenzoic Acid | N-Phenylanthranilic | NSC4273 | NSC-4273 | LP00011 | NSC 215211 | KBioSS_002304 | NCGC00093536-02 | N-PHENYLANTHRANILIC ACID [MI] | 2-(Phenylamino)benz

Especificaciones y pureza

AR, ≥95%

Condiciones de almacenamiento de almacenamiento

Protected from light, Room temperature

Enviado en

Normal

Grado

AR

Tipo de acción

CHANNEL BLOCKER

Mecanismo de acción

Channel blocker of ClC-2

Pureza

≥95%

Nombres e identificadores

• Sonrisas canónicas: C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)O
• IUPAC Name: 2-anilinobenzoic acid
• InChIKey: ZWJINEZUASEZBH-UHFFFAOYSA-N
• INCHI: 1S/C13H11NO2/c15-13(16)11-8-4-5-9-12(11)14-10-6-2-1-3-7-10/h1-9,14H,(H,15,16)
• Isómeros SMILES: C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)O
• WGK Alemania: 3
• RTECS: CB3730000
• Peso molecular: 213.23
• Beilstein: 1456607
• Reaxy-Rn: 1456607
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1456607&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Benzene and substituted derivatives
      • Subclass Benzoic acids and derivatives
        • Level5 Aminobenzoic acids and derivatives
          • Level6 Aminobenzoic acids

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Benzene and substituted derivatives
• Subclass: Benzoic acids and derivatives
• Intermediate Tree Nodes: Aminobenzoic acids and derivatives
• Direct Parent: Aminobenzoic acids
• Alternative Parents: Benzoic acids Benzoyl derivatives Aniline and substituted anilines Vinylogous amides Amino acids Secondary amines Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Aminobenzoic acid - Benzoic acid - Benzoyl - Aniline or substituted anilines - Vinylogous amide - Amino acid or derivatives - Amino acid - Secondary amine - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Amine - Hydrocarbon derivative - Aromatic homomonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as aminobenzoic acids. These are benzoic acids containing an amine group attached to the benzene moiety.
• External Descriptors: secondary amino compound - aminobenzoic acid

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

CA2 Tclin Carbonic anhydrase 2 (1 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA12 Tclin Carbonic anhydrase 12 (1 Activities)

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CA9 Tclin Carbonic anhydrase 9 (1 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKR1C2 Tchem Aldo-keto reductase family 1 member C2 (3 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLCN2 Tclin Chloride channel protein 2 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA2 Tclin Carbonic anhydrase II (17698 Activities)

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TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

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CACNA1C Tclin Voltage-gated L-type calcium channel alpha-1C subunit (766 Activities)

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LCK Tclin Tyrosine-protein kinase LCK (9212 Activities)

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FABP4 Tchem Fatty acid binding protein adipocyte (764 Activities)

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CA1 Tclin Carbonic anhydrase I (13240 Activities)

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SRC Tclin Tyrosine-protein kinase SRC (10310 Activities)

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ARSA Tbio Cerebroside-sulfatase (655 Activities)

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ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 Activities)

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CA12 Tclin Carbonic anhydrase XII (6231 Activities)

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CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

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CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

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CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

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CA9 Tclin Carbonic anhydrase IX (8255 Activities)

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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HepG2 (196354 Activities)

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SIRT2 Tchem NAD-dependent deacetylase sirtuin 2 (3979 Activities)

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SIRT1 Tchem NAD-dependent deacetylase sirtuin 1 (3505 Activities)

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AKR1C3 Tchem Aldo-keto-reductase family 1 member C3 (1414 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

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AKR1C2 Tchem Aldo-keto reductase family 1 member C2 (639 Activities)

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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SNCA Tchem Alpha-synuclein (10960 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

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LMNA Tbio Prelamin-A/C (36751 Activities)

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BLM Tchem Bloom syndrome protein (4248 Activities)

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)

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CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

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USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

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KCNK18 Tclin Potassium channel subfamily K member 18 (30 Activities)

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TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)

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Objetivos asociados (no humanos)

Saccharomyces cerevisiae (19171 Activities)

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Plasmodium falciparum (966862 Activities)

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Rattus norvegicus (775804 Activities)

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H4 (48 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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pfk 6-phospho-1-fructokinase (7870 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

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NS1 Nonstructural protein 1 (33327 Activities)

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CAN2 Carbonic anhydrase 2 (140 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in ethanol, DMSO (50 mg/ml), hot alcohol, and methanol. Insoluble in water
• Sensibilidad: Light sensitive
• Punto de fusión (°C): 185-188°C
• Peso molecular: 213.230 g/mol
• XLogP3: 4.400
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 213.079 Da
• Monoisotopic Mass: 213.079 Da
• Topological Polar Surface Area: 49.300 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 236.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Gao Li-wei, Lyu Shan-wu, Tang Jun, Zhou Dao-yun, Bonnema Guusje, Xiao Dong, Hou Xi-lin, Zhang Chang-wei.  (2017)  Genome-wide analysis of auxin transport genes identifies the hormone responsive patterns associated with leafy head formation in Chinese cabbage.  Scientific Reports,  7  (1): (1-13).  [PMID:28169368] [10.1038/srep42229]

2. Jiaqi Luo, Yingchen Wang, Qiutong Zhang, Wenhao Yan, Mingting Yuan, Yimin Jia, Qiushuo Yu, Xinyue Zhai, Yuan Zou.  (2025)  High-Sensitivity Measurement of Crystallization Induction Period Based on Fluorescence Method.  CRYSTAL GROWTH & DESIGN,      [PMID:] [10.1021/acs.cgd.5c00426]

3. Jiaqi Luo, Yingchen Wang, Qiutong Zhang, Wenhao Yan, Yimin Jia, Mingting Yuan, Qiushuo Yu, Xinyue Zhai, Yuan Zou.  (2025)  ESIPT mechanism and multi-stimuli-responsive of N-phenylanthranilic acid under AIE characteristics in solution.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2025.128962]